Compounds > n-butyl lactate
Page last updated: 2024-12-05

n-butyl lactate

n-Butyl lactate, also known as butyl lactate, is a colorless liquid with a sweet, fruity odor. It is a chiral compound, meaning it exists in two mirror-image forms (enantiomers). It is a renewable and biodegradable solvent with low toxicity, making it a promising alternative to traditional petrochemical solvents. n-Butyl lactate is synthesized through the esterification of lactic acid with n-butanol. It has been studied for its potential applications in various fields, including pharmaceuticals, cosmetics, and food industries. Its biodegradability and low toxicity make it suitable for use in environmentally friendly formulations. n-Butyl lactate is a valuable solvent due to its high solvency power, low volatility, and ability to dissolve a wide range of substances. It is also known to be an effective plasticizer and has been used in the production of biodegradable polymers.'

Cross-References

ID SourceID
PubMed CID8738
CHEMBL ID3183988
CHEBI ID169137
SCHEMBL ID26742
MeSH IDM0296239

Synonyms (61)

Synonym
CHEBI:169137
n-butyl lactate
butyl lactate
nsc-6533
2-hydroxypropanoic acid butyl ester
nsc6533
wln: qy1 & vo4
lactic acid, butyl ester
138-22-7
brn 1721597
ai3-00397
einecs 205-316-4
nsc 6533
butyl alpha-hydroxypropionate
butylester kyseliny mlecne [czech]
butyl lactate (natural)
fema no. 2205
butyl 2-hydroxypropanoate
propanoic acid, 2-hydroxy-, butyl ester
butyl lactate, 98%
inchi=1/c7h14o3/c1-3-4-5-10-7(9)6(2)8/h6,8h,3-5h2,1-2h3
mrabaeuhtlleml-uhfffaoysa-
L0002
lactic acid butyl ester
butyl 2-hydroxypropionate
butylester kyseliny mlecne
(+/-)-butyl lactate
4-03-00-00649 (beilstein handbook reference)
hsdb 7905
unii-0ui63w814u
0ui63w814u ,
cas-138-22-7
NCGC00255732-01
dtxsid7042196 ,
tox21_301349
dtxcid5022196
FT-0605224
FT-0627646
AKOS015903784
butyl .alpha.-hydroxypropionate
butyllactate
butyl lactate [inci]
butyl lactate [fhfi]
(+/-)-n-butyl lactate
.alpha.-hydroxypropionic acid butyl ester
SCHEMBL26742
1-butyl lactate
mfcd00004519
lactic acid n-butyl ester
CHEMBL3183988
fema 2205
2-hydroxy-butyl ester(2s)-propanoic acid
butyl alpha -hydroxypropionate
BS-15000
dl-butyl lactate
Q11370588
D70202
lactic acid-butyl ester
butyl2-hydroxypropanoate
475096-62-9
CS-W018230

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"Lactate esters have an oral LD50 greater than 2000 mg/kg and the inhalation LC50 is generally above 5000 mg/m3 and they may be potential eye and skin irritants, but not skin sensitizers."( Safety assessment of lactate esters.
Clary, JJ; Feron, VJ; van Velthuijsen, JA, 1998)		0.3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
carboxylic esterAn ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GLI family zinc finger 3Homo sapiens (human)Potency8.63490.000714.592883.7951AID1259369
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 34.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index34.76 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index44.85 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (34.76)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (28.57%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (71.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
lactic acid
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.		2.25102-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
vanillin
Vanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).		2.2510benzaldehydes;
monomethoxybenzene;
phenols		anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.0610aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		2.2110alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
acrylic acid
acrylic acid: RN given refers to parent cpd. acrylic acid : A alpha,beta-unsaturated monocarboxylic acid that is ethene substituted by a carboxy group.		2.2510alpha,beta-unsaturated monocarboxylic acidmetabolite
ethyl lactate
ethyl lactate: RN given refers to cpd with unspecified isomeric designation. ethyl 2-hydroxypropanoate : The ethyl ester obtained of 2-hydroxypropanoic acid.		3.0910ethyl ester;
lactate ester;
secondary alcohol		metabolite
n-butyl acrylate
butyl acrylate : An acrylate ester obtained by the formal condensation of the hydroxy group of butan-1-ol with the carboxy group of acrylic acid.		2.2510acrylate ester
isosorbide
Isosorbide: 1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma.		2.2510organic molecular entity
fructans
(2->6)-beta-D-fructan : A fructan compound consisting of repeating (2->6)-beta-linked fructofuranose units.		2.2110
ConditionIndicatedRelationship StrengthStudiesTrials
Hepatocellular Carcinoma
[description not available]		02.2110
Cancer of Liver
[description not available]		02.2110
Cancer of Lung
[description not available]		02.2110
Metastase
[description not available]		02.2110
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.2110
Liver Neoplasms
Tumors or cancer of the LIVER.		02.2110
Lung Neoplasms
Tumors or cancer of the LUNG.		02.2110
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.2110
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