rhizochaline: from Rhizochalina incrustata; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 44445587 |
| CHEMBL ID | 251453 |
| MeSH ID | M0186834 |
| Synonym |
|---|
| rhizochaline |
| CHEMBL251453 |
| rhizochalin |
| rhyzochalin |
| rhyzochaline |
| AKOS040753749 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Acetylcholine receptor subunit alpha | Tetronarce californica (Pacific electric ray) | Ki | 22.0000 | 0.0027 | 9.3596 | 34.0000 | AID743370 |
| Acetylcholine receptor subunit beta | Tetronarce californica (Pacific electric ray) | Ki | 22.0000 | 0.0027 | 11.7538 | 34.0000 | AID743370 |
| Acetylcholine receptor subunit gamma | Tetronarce californica (Pacific electric ray) | Ki | 22.0000 | 0.0027 | 11.7538 | 34.0000 | AID743370 |
| Acetylcholine receptor subunit delta | Tetronarce californica (Pacific electric ray) | Ki | 22.0000 | 0.0001 | 10.0747 | 34.0000 | AID743370 |
| Acetylcholine-binding protein | Lymnaea stagnalis (great pond snail) | Ki | 28.0000 | 0.0001 | 1.8811 | 28.0000 | AID743369 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID743369 | Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBP | 2014 | Marine drugs, Mar-28, Volume: 12, Issue:4 | Marine natural products acting on the acetylcholine-binding protein and nicotinic receptors: from computer modeling to binding studies and electrophysiology. |
| AID743370 | In vitro ability to inhibit the binding of [125I]alpha-bungarotoxin to Nicotinic acetylcholine receptor on membranes prepared from the electric organs of Torpedo californica | 2014 | Marine drugs, Mar-28, Volume: 12, Issue:4 | Marine natural products acting on the acetylcholine-binding protein and nicotinic receptors: from computer modeling to binding studies and electrophysiology. |
| AID312046 | Antifungal activity against fluconazole-resistant Candida glabrata | 2007 | Journal of natural products, Dec, Volume: 70, Issue:12 | Rhizochalins C and D from the sponge Rhizochalina incrustata. A rare threo-sphingolipid and a facile method for determination of the carbonyl position in alpha,omega-bifunctionalized ketosphingolipids. |
| AID377371 | Cytotoxicity against mouse Ehrlich cells | 2005 | Journal of natural products, Feb, Volume: 68, Issue:2 | Rhizochalin A, a novel two-headed sphingolipid from the sponge Rhizochalina incrustata. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||