rhizochaline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

rhizochaline: from Rhizochalina incrustata; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	44445587
CHEMBL ID	251453
MeSH ID	M0186834

Synonyms (6)

Synonym
rhizochaline
CHEMBL251453
rhizochalin
rhyzochalin
rhyzochaline
AKOS040753749

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Acetylcholine receptor subunit alpha	Tetronarce californica (Pacific electric ray)	Ki	22.0000	0.0027	9.3596	34.0000	AID743370
Acetylcholine receptor subunit beta	Tetronarce californica (Pacific electric ray)	Ki	22.0000	0.0027	11.7538	34.0000	AID743370
Acetylcholine receptor subunit gamma	Tetronarce californica (Pacific electric ray)	Ki	22.0000	0.0027	11.7538	34.0000	AID743370
Acetylcholine receptor subunit delta	Tetronarce californica (Pacific electric ray)	Ki	22.0000	0.0001	10.0747	34.0000	AID743370
Acetylcholine-binding protein	Lymnaea stagnalis (great pond snail)	Ki	28.0000	0.0001	1.8811	28.0000	AID743369
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID743369	Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBP	2014	Marine drugs, Mar-28, Volume: 12, Issue:4	Marine natural products acting on the acetylcholine-binding protein and nicotinic receptors: from computer modeling to binding studies and electrophysiology.
AID743370	In vitro ability to inhibit the binding of [125I]alpha-bungarotoxin to Nicotinic acetylcholine receptor on membranes prepared from the electric organs of Torpedo californica	2014	Marine drugs, Mar-28, Volume: 12, Issue:4	Marine natural products acting on the acetylcholine-binding protein and nicotinic receptors: from computer modeling to binding studies and electrophysiology.
AID312046	Antifungal activity against fluconazole-resistant Candida glabrata	2007	Journal of natural products, Dec, Volume: 70, Issue:12	Rhizochalins C and D from the sponge Rhizochalina incrustata. A rare threo-sphingolipid and a facile method for determination of the carbonyl position in alpha,omega-bifunctionalized ketosphingolipids.
AID377371	Cytotoxicity against mouse Ehrlich cells	2005	Journal of natural products, Feb, Volume: 68, Issue:2	Rhizochalin A, a novel two-headed sphingolipid from the sponge Rhizochalina incrustata.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (80.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
aaptamine aaptamine: natural product from sea sponge Aaptos aaptos; structure given in first source; RN from CA Index Guide 1984	2.1	1
glycosides [no description available]	2.45	2
monanchocidin monanchocidin: from the marine sponge Monanchora; structure in first source	2.1	1	organic molecular entity	metabolite
debromohymenialdisine [no description available]	2.1	1

Condition	Relationship Strength	Studies
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	2.05	1
Leucocythaemia [description not available]	2.05	1
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	2.05	1

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