Page last updated: 2024-12-08

licam-c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

LICAM-C: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	173493
MeSH ID	M0107108

Synonyms (8)

Synonym
licam-c
4-[4-[(4-carboxy-2,3-dihydroxybenzoyl)-[3-[(4-carboxy-2,3-dihydroxybenzoyl)amino]propyl]amino]butylcarbamoyl]-2,3-dihydroxybenzoic acid
benzoic acid, 4-(((4-((4-carboxy-2,3-dihydroxybenzoyl)amino)butyl)(3-((4-carboxy-2,3-dihydroxybenzoyl)amino)propyl)amino)carbonyl)-2,3-dihydroxy-
n,n',n''-tris(2,3-dihydroxy-4-carboxybenzoyl)-1,5,10-triazadecane
75956-68-2
DTXSID90226858
4-((4-(4-carboxy-2,3-dihydroxybenzamido)butyl)(3-(4-carboxy-2,3-dihydroxybenzamido)propyl)carbamoyl)-2,3-dihydroxybenzoic acid
AKOS040752563

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" With early treatment and at the dosage used clinically for the decorporation of actinides with DTPA (30 mumol/kg body weight) LICAM(C) was superior to DFOA but when compared with DTPA, the effect of LICAM(C) on 238Pu was greater only in bone; as little as 1 mumol LICAM(C)/kg was as effective as 30 mumol DTPA/kg."	( Chelation therapy of incorporated plutonium-238 and americium-241: comparison of LICAM(C), DTPA and DFOA in rats, hamsters and mice. Volf, V, 1986)	0.27

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	17 (94.44)	18.7374
1990's	1 (5.56)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
nitrates Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.	2.66	3	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species
spermidine [no description available]	4.22	18	polyazaalkane; triamine	autophagy inducer; fundamental metabolite; geroprotector
spermine [no description available]	2.37	2	polyazaalkane; tetramine	antioxidant; fundamental metabolite; immunosuppressive agent
deferoxamine Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.	1.96	1	acyclic desferrioxamine	bacterial metabolite; ferroptosis inhibitor; iron chelator; siderophore
pentetic acid Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	3.84	12	pentacarboxylic acid	copper chelator
plutonium Plutonium: A naturally radioactive element of the actinide metals series. It has the atomic symbol Pu, and atomic number 94. Plutonium is used as a nuclear fuel, to produce radioisotopes for research, in radionuclide batteries for pacemakers, and as the agent of fission in nuclear weapons.	9.16	17	actinoid atom; f-block element atom
americium Americium: A completely man-made radioactive actinide with atomic symbol Am, and atomic number 95. Its valence can range from +3 to +6. Because of its nonmagnetic ground state, it is an excellent superconductor. It is also used in bone mineral analysis and as a radiation source for radiotherapy.	3.35	7	actinoid atom; f-block element atom
tributyl phosphate tributyl phosphate: a detergent. tributyl phosphate : A trialkyl phosphate that is the tributyl ester of phosphoric acid.	1.96	1	trialkyl phosphate
transferrin Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.	7.37	2
plutonium nitrate plutonium nitrate: RN given refers to cpd with MF of Pu-HNO3	1.97	1
americium nitrate americium nitrate: RN given refers to parent cpd	2.37	2
n,n',n''-tris(2,3-dihydroxy-5-sulfobenzoyl)-1,5,10-triazadecane N,N',N''-tris(2,3-dihydroxy-5-sulfobenzoyl)-1,5,10-triazadecane: octahedrally coordinates metal ion via six phenolic oxygens; structure in first source	2.65	3

Condition	Indicated	Relationship Strength	Studies	Trials
Abscess Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.	0	1.96	1	0
Experimental Radiation Injuries [description not available]	0	1.97	1	0

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