Compounds > garcinielliptone fc
Page last updated: 2024-11-13

garcinielliptone fc

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

garcinielliptone FC: from seeds of Platonia insignis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Platoniagenus[no description available]ClusiaceaeThe mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.[MeSH]

Cross-References

ID SourceID
PubMed CID24850574
MeSH IDM0575125

Synonyms (2)

Synonym
garcinielliptone fc
(1r,5r,7s)-1-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-3,5-bis(3-methylbut-2-enyl)-7-[(2s)-5-methyl-2-prop-1-en-2-ylhex-5-enyl]bicyclo[3.3.1]non-3-ene-2,9-dione

Research Excerpts

Overview

Garcinielliptone FC (GFC) is a polyprenylated benzophenone isolated from the hexanic extract of Platonia insignis seeds. It has proven to have antiepileptic, cytotoxic and antioxidant activity.

ExcerptReferenceRelevance
"Garcinielliptone FC (GFC) is a polyisoprenylated benzophenone isolated from Platonia insignis Mart (Clusiaceae) with promising anticonvulsant properties. "( A 28-day Sub-acute Genotoxic and Behavioural Assessment of Garcinielliptone FC.
Coelho, VR; Corrêa, DS; Dallegrave, E; de Souza, LP; Ferraz, ABF; Leal, MB; Pereira, P; Pfluger, P; Picada, JN; Prado, LS; Regner, GG; Rossato, RR; Valle, MTC; Vieira, CG, 2018)		2.17
"Garcinielliptone FC (GFC) is a natural prenylated benzophenone found in the seeds of Platonia insignis Mart. "( Garcinielliptone FC: antiparasitic activity without cytotoxicity to mammalian cells.
Costa Júnior, JS; de Moraes, J; Freitas, RM; Mendonça, RZ; Monteiro, DC; Oliveira, CG; Pinto, PL; Silva, AP; Silva, MP, 2015)		3.3
"Garcinielliptone FC (GFC) is a tautomeric pair of polyprenylated benzophenone, which has proven to have antiepileptic, cytotoxic and antioxidant activity."( Pre-clinical toxicology of garcinielliptone FC, a tautomeric pair of polyprenylated benzophenone, isolated from Platonia insignis Mart seeds.
da Costa Junior, JS; da Silva, AP; David, JM; de Freitas, RM; Lopes, Lda S; Medeiros, SC; Oliveira, GL; Sousa, AM, 2016)		2.17
"Garcinielliptone FC (GFC) is a polyprenylated benzophenone isolated from the hexanic extract of Platonia insignis seeds with potential pharmacological effects on the central nervous system. "( Evaluation of DNA Damage in HepG2 Cells and Mutagenicity of Garcinielliptone FC, A Bioactive Benzophenone.
Boaretto, FBM; Conter, LU; da Silva Prado, L; da Silva, J; de Barros Falcão Ferraz, A; de Oliveira Salvi, A; Garcia, ALH; Grivicich, I; Picada, JN; Reginatto, FH; Vencato, SB, 2017)		2.14

Actions

ExcerptReferenceRelevance
"Garcinielliptone FC did not increase micronucleus frequency in bone marrow."( A 28-day Sub-acute Genotoxic and Behavioural Assessment of Garcinielliptone FC.
Coelho, VR; Corrêa, DS; Dallegrave, E; de Souza, LP; Ferraz, ABF; Leal, MB; Pereira, P; Pfluger, P; Picada, JN; Prado, LS; Regner, GG; Rossato, RR; Valle, MTC; Vieira, CG, 2018)		1.45
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (75.00)24.3611
2020's3 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.01

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.01 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.57 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.01)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phloroglucinol
Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.. phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.		7.610benzenetriol;
phenolic donor		algal metabolite
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)		2.2510monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
benzophenone
benzophenone : The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups.		7.0810benzophenonesphotosensitizing agent;
plant metabolite
pilocarpine
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.. (+)-pilocarpine : The (+)-enantiomer of pilocarpine.		7.110pilocarpineantiglaucoma drug
phenylephrine
Phenylephrine: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.. phenylephrine : A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.		2.110phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent
lucanthone hydrochloride
Schistosomicides: Agents that act systemically to kill adult schistosomes.		2.1110
xanthochymol
xanthochymol: isolated from the fruits of Garcinia pyrifera collected in Malaysia; structure in first source		2.610
garcinol
garcinol: from stem bark of Garcinia huillensis; has chemotherapeutic activity against gram-positive & gram-negative cocci, mycobacteria & fungi		2.3110
ConditionIndicatedRelationship StrengthStudiesTrials
Extravascular Hemolysis
[description not available]		02.2510
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.2510
Absence Seizure
[description not available]		02.110
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		07.110
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.1310
Colorectal Cancer
[description not available]		07.1710
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.1710