Page last updated: 2024-12-06

carbuterol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Carbuterol is a synthetic beta2-adrenergic receptor agonist. It is used as a bronchodilator to treat asthma and other respiratory conditions. Carbuterol is typically administered by inhalation and has a long duration of action. It is not typically synthesized in the laboratory, but rather obtained through commercial manufacturing processes. Carbuterol acts by stimulating beta2 receptors in the lungs, leading to relaxation of smooth muscle and bronchodilation. It has been shown to have therapeutic effects in improving lung function and reducing symptoms in patients with asthma. Carbuterol is studied because of its potential for treating respiratory conditions and for understanding the mechanisms of action of beta2-adrenergic receptor agonists.'

carbuterol: sympathomimetric specific for beta2 receptors; proposed bronchodilator agent; minor descriptor (78-86); on-line & INDEX MEDICUS search ETHANOLAMINES (78-86); RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID36976
CHEMBL ID2110780
CHEBI ID135100
SCHEMBL ID37370
MeSH IDM0263173

Synonyms (25)

Synonym
carbuterol
bronsecur
einecs 252-257-5
carbuterol [inn:ban]
(5-(2-(tert-butylamino)-1-hydroxyethyl)-2-hydroxyphenyl)urea
carbuterolum [inn-latin]
[5-[2-(tert-butylamino)-1-hydroxyethyl]-2-hydroxyphenyl]urea
0n12jr32mr ,
34866-47-2
unii-0n12jr32mr
carbuterolum
carbuterol [who-dd]
carbuterol [inn]
carbuterol [mi]
urea, (5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)-
SCHEMBL37370
CHEMBL2110780
CHEBI:135100
urea, [5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]-
Q5038111
2-chloro-3-methoxybenzoicacid97
DB13625
n-{5-[2-(tert-butylamino)-1-hydroxyethyl]-2-hydroxyphenyl}urea
DTXSID00865737
{5-[2-(tert-butylamino)-1-hydroxyethyl]-2-hydroxyphenyl}urea

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The characteristics of the oral route are easy usage, precise dosage and assured effects."( Oral beta 2-selective adrenergic bronchodilators.
Daniotti, S; Dottorini, M; Grassi, V; Schiassi, M; Tantucci, C, 1986
)
0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
ureas
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID1146180Agonist activity at beta-2 adrenergic receptor in guinea pig tracheal chain assessed as relaxation of spontaneously contracted tracheal smooth muscle1977Journal of medicinal chemistry, Oct, Volume: 20, Issue:10
Adrenergic agents. 8.1 Synthesis and beta-adrenergic agonist activity of some 3-tert-butylamino-2-(substituted phenyl)-1-propanols.
AID1146185Intrinsic activity at beta-2 adrenergic receptor in guinea pig tracheal chain assessed as relaxation of spontaneously contracted tracheal smooth muscle relative to papaverine1977Journal of medicinal chemistry, Oct, Volume: 20, Issue:10
Adrenergic agents. 8.1 Synthesis and beta-adrenergic agonist activity of some 3-tert-butylamino-2-(substituted phenyl)-1-propanols.
AID1146181Agonist activity at beta-1 adrenergic receptor in guinea pig right atria assessed as increase in contraction rate of spontaneously beating right atria1977Journal of medicinal chemistry, Oct, Volume: 20, Issue:10
Adrenergic agents. 8.1 Synthesis and beta-adrenergic agonist activity of some 3-tert-butylamino-2-(substituted phenyl)-1-propanols.
AID1146183Intrinsic activity at beta-1 adrenergic receptor in guinea pig right atria assessed as increase in contraction rate of spontaneously beating right atria relative to isoproterenol1977Journal of medicinal chemistry, Oct, Volume: 20, Issue:10
Adrenergic agents. 8.1 Synthesis and beta-adrenergic agonist activity of some 3-tert-butylamino-2-(substituted phenyl)-1-propanols.
AID1146184Selectivity ratio of ED25 for beta-1 adrenergic receptor in guinea pig right atria to ED50 for beta-2 adrenergic receptor in guinea pig tracheal chain1977Journal of medicinal chemistry, Oct, Volume: 20, Issue:10
Adrenergic agents. 8.1 Synthesis and beta-adrenergic agonist activity of some 3-tert-butylamino-2-(substituted phenyl)-1-propanols.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19909 (90.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 36.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index36.29 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index50.49 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (36.29)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials5 (31.25%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (68.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]