Page last updated: 2024-11-10

c,n-diphenylnitrone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

C,N-diphenylnitrone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3036381
CHEMBL ID1865314
SCHEMBL ID12349218
MeSH IDM0506933

Synonyms (38)

Synonym
(z)-benzylidene(phenyl)azane oxide
benzenemethanimine,.alpha.-phenyl-n-oxide
benzenamine, n-(phenylmethylene)-, n-oxide
benzaldehydephenylnitrone
c,n-diphenylnitrone
nsc-102882
nsc102882
.alpha.,n-diphenylnitrone
n,.alpha.-diphenylnitrone
1137-96-8
STK392291
n-phenyl-n-[(z)-phenylmethylidene]amine oxide
MLS002206501
smr001295317
AKOS000281753
n-benzylideneaniline n-oxide
n,1-diphenylmethanimine oxide
n-benzylidene-n-phenylamine oxide
A803095
benzenemethanimine, alpha-phenyl-, n-oxide
59862-61-2
nitrone, n,alpha-diphenyl-
HMS2201F20
n,alpha-diphenyl nitrone
CHEMBL1865314
SCHEMBL12349218
(z)-c,n-diphenylnitrone
n,1-diphenyl-methanimine oxide
n, alpha -diphenyl nitrone
n,a-diphenylnitrone
BAA13796
benzenamine, n-(phenylmethylene)-, n-oxide, [n(z)]-
n-phenylbenzylidenamine n-oxide
cis-c,n-diphenyl nitrone
n-(phenylmethylene)benzenamine n-oxide
L7MP2M8WUP
benzylideneaniline nitrone
n-phenylbenzylimine n-oxide
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency19.01150.007215.758889.3584AID588342
TDP1 proteinHomo sapiens (human)Potency29.09290.000811.382244.6684AID686978; AID686979
67.9K proteinVaccinia virusPotency12.58930.00018.4406100.0000AID720579
gemininHomo sapiens (human)Potency0.06510.004611.374133.4983AID624296
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID1269232Toxicity in H2O2 stressed human SH-SY5Y cells assessed as effect on total glutathione level at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 24 hrs by spectrophotometric analysis2016Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2
α-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus.
AID1269225Cytoprotective activity against H2O2-induced apoptosis in human SH-SY5Y cells assessed as dead cells at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric analysis2016Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2
α-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus.
AID1269228Cytoprotective activity against H2O2-induced apoptosis in human SH-SY5Y cells assessed as early apoptotic cells at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometr2016Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2
α-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus.
AID1269226Cytoprotective activity against H2O2-induced apoptosis in human SH-SY5Y cells assessed as late apoptotic cells at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometri2016Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2
α-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus.
AID1269235Cytoprotective activity against H2O2-induced toxicity in human SH-SY5Y cells assessed as increase in cell viability at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 24 hrs by MTT assay relative to PBN2016Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2
α-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus.
AID1269234Cytoprotective activity against H2O2 stressed human SH-SY5Y cells assessed as increase in glutathione level at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 24 hrs by spectrophotometric analysis2016Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2
α-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus.
AID1269227Cytoprotective activity against H2O2-induced apoptosis in human SH-SY5Y cells assessed as viable cells at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric analys2016Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2
α-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus.
AID1269233Cytoprotective activity against H2O2-induced oxidative stress in human SH-SY5Y cells at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 24 hrs by DCFHDA dye-based flow cytometric analysis2016Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2
α-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus.
AID1269224Cytoprotective activity against H2O2-induced toxicity in human SH-SY5Y cells assessed as increase in cell viability at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 24 hrs by MTT assay relative to control2016Bioorganic & medicinal chemistry, Jan-15, Volume: 24, Issue:2
α-Aryl-N-aryl nitrones: Synthesis and screening of a new scaffold for cellular protection against an oxidative toxic stimulus.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's4 (50.00)24.3611
2020's2 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.15 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.34 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]