Page last updated: 2024-12-10

c 31g

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

C 31G: mixture of above cpds [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	3086239
SCHEMBL ID	15532154
MeSH ID	M0115548

Synonyms (5)

Synonym
c-31g
86903-77-7
c 31g
SCHEMBL15532154
carboxymethyl-dodecyl-dimethylazanium;n,n-dimethyldodecan-1-amine oxide

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" C31G was shown to be safe to both vaginal and rectal mucosal tissues and to the microflora with repeated daily use."	( Vaginal and rectal topical microbicide development: safety and efficacy of 1.0% Savvy (C31G) in the pigtailed macaque. Balkus, JE; Hillier, SL; Patton, DL; Sweeney, YT, 2006)	0.33
" Measured outcomes included pregnancy rates, continuation rates, adverse events, and acceptability."	( Contraceptive efficacy, acceptability, and safety of C31G and nonoxynol-9 spermicidal gels: a randomized controlled trial. Archer, D; Barnhart, K; Blithe, D; Burke, AE; Carr, BR; Creinin, MD; Jensen, JT; Liu, J; Schlaff, W; Thomas, M; Walsh, TL; Wan, LS; Westhoff, C; Wu, H, 2010)	0.36
" Two serious adverse events were deemed possibly related to study product and neither occurred in the C31G group."	( Contraceptive efficacy, acceptability, and safety of C31G and nonoxynol-9 spermicidal gels: a randomized controlled trial. Archer, D; Barnhart, K; Blithe, D; Burke, AE; Carr, BR; Creinin, MD; Jensen, JT; Liu, J; Schlaff, W; Thomas, M; Walsh, TL; Wan, LS; Westhoff, C; Wu, H, 2010)	0.36

Dosage Studied

Excerpt	Relevance	Reference
" Kinetic studies of absorption and disposition after oral dosing in mice with [3H]C31G were used to determine the body burden (0."	( Mice and rabbit models for oral and percutaneous absorption and disposition of amphoteric surfactant C31G. Hahn, EC; Kenyon, AJ; Michaels, EB, 1983)	0.27
" C31G, a surface active anti-infective agent that is active in vitro against bacterial and viral STD pathogens, was evaluated in a 3-day, once-daily dosing clinical trial designed to assess multiple formulations for safety and acceptance."	( Microbicides--evaluating multiple formulations of C31G. Bax, R; Bowden, M; Douville, K; Higgins, J; McCormick, D; Rosenberg, M, 2002)	0.31

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (31)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (16.13)	18.7374
1990's	9 (29.03)	18.2507
2000's	12 (38.71)	29.6817
2010's	5 (16.13)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	26.28 (24.57)
Research Supply Index	3.76 (2.92)
Research Growth Index	4.54 (4.65)
Search Engine Demand Index	40.77 (26.88)
Search Engine Supply Index	3.03 (0.95)

This Compound (26.28)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	11 (35.48%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	20 (64.52%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
betaine glycine betaine : The amino acid betaine derived from glycine.	9.21	31	11	amino-acid betaine; glycine derivative	fundamental metabolite
cetylpyridinium Cetylpyridinium: Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.	3.37	1	1	pyridinium ion
triclosan [no description available]	3.37	1	1	aromatic ether; dichlorobenzene; monochlorobenzenes; phenols	antibacterial agent; antimalarial; drug allergen; EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; fungicide; persistent organic pollutant; xenobiotic
nonoxynol Nonoxynol: Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Nonoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide, formulated primarily as a component of vaginal foams and creams.	6.84	9	3
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	1.96	1	0	diatomic chlorine; gas molecular entity	bleaching agent
chlorine dioxide chlorine dioxide: equal or superior to chlorine when used as wastewater disinfectant	1.96	1	0	chlorine dioxide
cellulose sulfate cellulose sulfate: RN given refers to cpd with unknown MF; vaginal gel being developed as both a contraceptive and blockage to STD somewhat like nonoxynol-9	2.06	1	0	ether; flavonoids
listerine Listerine: hydroalcohol solution containing thymol, menthol, eucalyptol, methyl salicylate & alcohol	3.36	1	1
bromochloroacetic acid Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.. bromochloroacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by bromine while a second is replaced by chlorine. A low-melting (27.5-31.5degreeC), hygroscopic crystalline solid, it can be formed during the disinfection (by chlorination) of water that contains bromide ions and organic matter, so can occur in drinking water as a byproduct of the disinfection process.	2	1	0	2-bromocarboxylic acid; monocarboxylic acid; organochlorine compound
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	2.92	4	0	organic sodium salt	detergent; protein denaturant
chlorhexidine Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.. chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.	4.38	2	2	biguanides; monochlorobenzenes	antibacterial agent; antiinfective agent
cellulose DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.	3.82	2	1	glycoside
salicylates Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.	3.36	1	1	monohydroxybenzoate	plant metabolite

Condition	Relationship Strength	Studies	Trials
Parodontosis [description not available]	3.56	1	1
Periodontal Diseases Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.	3.56	1	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.46	2	0
Herpes Simplex Keratitis [description not available]	2.08	1	0
Keratitis, Herpetic A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (KERATITIS, DENDRITIC). (Dictionary of Visual Science, 3d ed)	2.08	1	0
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	4.36	1	1
HIV Coinfection [description not available]	2.06	1	0
HIV Infections Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).	2.06	1	0
Sexually Transmitted Diseases Diseases due to or propagated by sexual contact.	4.65	3	2
Vaginitis Inflammation of the vagina characterized by pain and a purulent discharge.	3.4	1	1
Innate Inflammatory Response [description not available]	2.02	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.02	1	0
Infections, Chlamydia [description not available]	2.41	2	0
Chlamydia Infections Infections with bacteria of the genus CHLAMYDIA.	2.41	2	0
Mastitis, Bovine INFLAMMATION of the UDDER in cows.	1.96	1	0
Infections, Staphylococcal [description not available]	2.37	2	0
Wounds, Penetrating Wounds caused by objects penetrating the skin.	1.96	1	0
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	2.37	2	0
Dental Plaque A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.	4.97	3	3
Caries, Dental [description not available]	3.36	1	1
Dental Caries Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.	3.36	1	1
Gingivitis Inflammation of gum tissue (GINGIVA) without loss of connective tissue.	3.36	1	1
Infection, Postoperative Wound [description not available]	1.96	1	0

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