c-31g has been researched along with Dental-Plaque* in 3 studies
3 trial(s) available for c-31g and Dental-Plaque
Article | Year |
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A comparison of chlorhexidine, cetylpyridinium chloride, triclosan, and C31G mouthrinse products for plaque inhibition.
There are a large number of mouthrinse products available to the general public for use as adjuncts to oral hygiene. Many have not been evaluated and relatively few comparisons of products have been made. This study compared 4 mouthrinse products containing cetylpyridinium chloride (CPC), chlorhexidine, C31G, or triclosan with saline rinse included as a placebo control. Twenty dentate volunteers took part in this 4-day plaque regrowth study which had a single blind, randomized cross-over design balanced for residual effects. On day 1 of each study period, volunteers were rendered plaque free by a professional prophylaxis, suspended normal oral hygiene measures, and rinsed twice daily for 1 minute with 15 mL of the allocated rinse. On day 5, subjects were scored for disclosed plaque by plaque index and plaque area. By both measures the order of decreasing product efficacy was chlorhexidine, CPC and triclosan, C31G, and saline. All the differences in favor of the chlorhexidine product were highly significant as were those in favor of the other rinses compared to saline. It is concluded that the findings of this study reflect the actual chemical benefits of the products divorced from the indeterminate variable of toothbrushing. Topics: Adult; Anti-Infective Agents, Local; Betaine; Cetylpyridinium; Chlorhexidine; Cross-Over Studies; Dental Plaque; Fatty Acids, Unsaturated; Female; Humans; Male; Maleates; Mouthwashes; Polyvinyls; Single-Blind Method; Triclosan | 1996 |
[The effect of a chemotherapeutical amine containing toothpaste on plaque formation, gingivitis and caries in clinical and animal experiment].
"C31G" means and amine mixture, which shall be, a new "sure" substance of small toxicity and is used as an effective plaque and caries reducing chemotherapeutical substance in a tooth paste. In this study we report on: the caries reducing effect in the teeth cleaning experiment in Osborn-Mendel-rats (96 animals, 6 Groups) with C-31G-containing tooth pastes in different concentrations and also in combinations with and without fluoride. the effect of an 1% C31G-containing tooth paste on plaque formation (SLI + QHI) and gingivitis (SBI) in a clinical double blind cross over-study (section % patients, 2 groups, 2 pre-experimental OH-Plases, teeth cleaning once per day). The study results don't show the expected plaque and caries reducind effect. The results of the in vivo and in vitro experiments call for a critical examination of the substances with attention of further parameters. Topics: Analysis of Variance; Animals; Betaine; Dental Caries; Dental Plaque; Double-Blind Method; Evaluation Studies as Topic; Fatty Acids, Unsaturated; Gingivitis; Humans; Rats; Toothpastes | 1991 |
Clinical study of a C31G containing mouthrinse: effect on salivary microorganisms.
In vitro studies have demonstrated the antiplaque properties of C31G, a potent broad spectrum antimicrobial agent consisting of an equimolar mixture of alkyl dimethyl glycine and alkyl dimethyl amine oxide, buffered with citric acid. In this initial clinical study, C31G at concentrations of 0.05%, 0.1%, 0.2% and 0.5%. Listerine, and placebo were tested in a complete crossover design. Twelve subjects were evaluated, with a minimum of 2 days between treatments. Parameters monitored were salivary bacterial counts and saliva glycolysis. The 0.5% and 0.2% C31G mouthrinses significantly reduced total bacterial counts in saliva samples obtained up to and including three hours after rinsing, compared with counts obtained prerinsing or after placebo rinsing. Both 0.5%, and 0.2% C31G significantly inhibited glycolysis of salivary bacteria for up to 6 hours postrinsing, compared with pH values obtained prerinsing. 0.1% and 0.05% C31G exhibited little or no effect in either assay. Listerine showed a significant reduction in bacterial counts for up to 1 hour postrinsing, compared with prerinse counts, but the effect was less sustained. Listerine showed no significant inhibition of glycolysis at any time point. No tooth staining or altered taste sensation was noted with either product. Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Bacteria; Betaine; Dental Plaque; Drug Combinations; Fatty Acids, Unsaturated; Glycolysis; Humans; Mouthwashes; Salicylates; Saliva; Streptococcus; Terpenes | 1990 |