Compounds > bengamide b
Page last updated: 2024-11-11

bengamide b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

bengamide B: isolated from a Jaspidae marine sponge; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6444128
CHEMBL ID446079
SCHEMBL ID909970
MeSH IDM0389240

Synonyms (11)

Synonym
bengamide b
[(3s,6s)-1-methyl-7-oxo-6-[[(e,2r,3r,4s,5r)-3,4,5-trihydroxy-2-methoxy-8-methyl-non-6-enoyl]amino]azepan-3-yl] tetradecanoate
6-((4s,2r,3r,5r)-3,4,5-trihydroxy-2-methoxy-8-methylnon-6-enoylamino)(3s,6s)-1-methyl-7-oxoazaperhydroepin-3-yl tetradecanoate
CHEMBL446079
[(3s,6s)-1-methyl-7-oxo-6-[[(e,2r,3r,4s,5r)-3,4,5-trihydroxy-2-methoxy-8-methylnon-6-enoyl]amino]azepan-3-yl] tetradecanoate
104947-69-5
SCHEMBL909970
AKOS025142071
(6e)-6,7,8,9-tetradeoxy-n-[(3s,6s)-hexahydro-1-methyl-2-oxo-6-[(1-oxotetradecyl)oxy]-1h-azepin-3-yl]-8-methyl-2-o-methyl-d-gulo-non-6-enonamide
J-001295
bengamideb
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID674395Inhibition of LPS-stimulated NFkappaB activation transfected in mouse RAW264.7 cells at 0.01 to 10 uM after 4 hrs by measuring IKappaBalpha phosphorylation by Western blot analysis2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
AID674398Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated TNFalpha expression up to 10 uM by quantitative RT-PCR analysis2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
AID1484172Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by MTS assay2017Journal of natural products, 03-24, Volume: 80, Issue:3
The Bengamides: A Mini-Review of Natural Sources, Analogues, Biological Properties, Biosynthetic Origins, and Future Prospects.
AID379500Antimicrobial activity against Saccharomyces cerevisiae ATCC 28383 after 24 hrs by liquid-phase turbidimetric system1999Journal of natural products, May, Volume: 62, Issue:5
Antifungal metabolites from the marine sponge Pachastrissa sp.: new bengamide and bengazole derivatives.
AID674393Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
AID674399Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated IL-6 expression up to 10 uM by quantitative RT-PCR analysis2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
AID379499Antifungal activity against Candida albicans CIP 118079 after 24 hrs by liquid-phase turbidimetric system1999Journal of natural products, May, Volume: 62, Issue:5
Antifungal metabolites from the marine sponge Pachastrissa sp.: new bengamide and bengazole derivatives.
AID745720Inhibition of methionine aminopeptidase in human PC3 cells assessed as increase in ratio of unprocessed 14-3-3gamma to total 14-3-3gamma at 0.1 uM after 24 hrs by immunoblotting analysis relative to DMSO-treated control2013Journal of medicinal chemistry, May-23, Volume: 56, Issue:10
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
AID674392Inhibition of LPS-stimulated NFkappaB activation transfected in mouse RAW264.7 cells after 18 hrs by luciferase reporter gene assay2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
AID745719Inhibition of methionine aminopeptidase in human MCF7 cells assessed as increase in ratio of unprocessed 14-3-3gamma to total 14-3-3gamma at 0.1 uM after 24 hrs by immunoblotting analysis relative to DMSO-treated control2013Journal of medicinal chemistry, May-23, Volume: 56, Issue:10
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
AID674400Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated MCP1 expression up to 10 uM by quantitative RT-PCR analysis2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
AID1484171Aqueous solubility of the compound at pH 6.82017Journal of natural products, 03-24, Volume: 80, Issue:3
The Bengamides: A Mini-Review of Natural Sources, Analogues, Biological Properties, Biosynthetic Origins, and Future Prospects.
AID674397Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated iNOS expression up to 10 uM by quantitative RT-PCR analysis2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
AID674396Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production up to 10 uM after 30 mins by Greiss method2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
AID745706Inhibition of methionine aminopeptidase 1 in human HeLa cells assessed as increase in ratio of unprocessed 14-3-3gamma to total 14-3-3gamma at 0.1 uM after 24 hrs by immunoblotting analysis relative to DMSO-treated control2013Journal of medicinal chemistry, May-23, Volume: 56, Issue:10
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
AID674394Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's4 (40.00)29.6817
2010's4 (40.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.75 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.96 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
2,2'-dipyridyl
2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.		2.0810bipyridinechelator;
ferroptosis inhibitor
thiabendazole
Tresaderm: dermatologic soln containing dexamethasone, thiabendazole & neomycin sulfate		2.08101,3-thiazoles;
benzimidazole fungicide;
benzimidazoles		antifungal agrochemical;
antinematodal drug
caprolactam
Caprolactam: Cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. Can cause local irritation.. epsilon-caprolactam : A member of the class of caprolactams that is azepane substituted by an oxo group at position 2.		2.0410caprolactamshuman blood serum metabolite
celastrol
[no description available]		2.0710monocarboxylic acid;
pentacyclic triterpenoid		anti-inflammatory drug;
antineoplastic agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Hsp90 inhibitor;
metabolite
o-(chloroacetylcarbamoyl)fumagillol
O-(Chloroacetylcarbamoyl)fumagillol: Semisynthetic analog of fumagillin (a cyclohexane-sesquiterpene antibiotic isolated from ASPERGILLUS FUMIGATUS) that inhibits angiogenesis.. O-(chloroacetylcarbamoyl)fumagillol : A carbamate ester that is fumagillol in which the hydroxy group has been converted to the corresponding N-(chloroacetyl)carbamate derivative.		2.0810carbamate ester;
organochlorine compound;
semisynthetic derivative;
sesquiterpenoid;
spiro-epoxide		angiogenesis inhibitor;
antineoplastic agent;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
methionine aminopeptidase 2 inhibitor;
retinoic acid receptor alpha antagonist
bengamide e
bengamide E: isolated from a Jaspidae marine spnoge; from structure in first source		4.3860N-acyl-amino acid
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		02.2510
Colonic Neoplasms
Tumors or cancer of the COLON.		02.2510
Breast Cancer
[description not available]		02.0410
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0410