Compounds > bengamide e
Page last updated: 2024-12-11

bengamide e

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

bengamide E: isolated from a Jaspidae marine spnoge; from structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6444155
CHEMBL ID376628
CHEBI ID188639
SCHEMBL ID587721
MeSH IDM0389241

Synonyms (6)

Synonym
bengamide e
CHEMBL376628
CHEBI:188639
(e,2r,3r,4s,5r)-3,4,5-trihydroxy-2-methoxy-8-methyl-n-[(3s)-2-oxoazepan-3-yl]non-6-enamide
118477-03-5
SCHEMBL587721
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
N-acyl-amino acidA carboxamide resulting from the formal condensation of a carboxylic acid with the amino group of an amino acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID275979Cytotoxicity against mouse CFU-GM cells at 7.8 ug/disk2007Journal of natural products, Jan, Volume: 70, Issue:1
A distinctive structural twist in the aminoimidazole alkaloids from a calcareous marine sponge: isolation and characterization of leucosolenamines A and B.
AID1484174Antiproliferative activity against human HCT116 cells after 96 hrs2017Journal of natural products, 03-24, Volume: 80, Issue:3
The Bengamides: A Mini-Review of Natural Sources, Analogues, Biological Properties, Biosynthetic Origins, and Future Prospects.
AID674395Inhibition of LPS-stimulated NFkappaB activation transfected in mouse RAW264.7 cells at 0.01 to 10 uM after 4 hrs by measuring IKappaBalpha phosphorylation by Western blot analysis2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
AID1484172Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by MTS assay2017Journal of natural products, 03-24, Volume: 80, Issue:3
The Bengamides: A Mini-Review of Natural Sources, Analogues, Biological Properties, Biosynthetic Origins, and Future Prospects.
AID379500Antimicrobial activity against Saccharomyces cerevisiae ATCC 28383 after 24 hrs by liquid-phase turbidimetric system1999Journal of natural products, May, Volume: 62, Issue:5
Antifungal metabolites from the marine sponge Pachastrissa sp.: new bengamide and bengazole derivatives.
AID674394Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
AID379499Antifungal activity against Candida albicans CIP 118079 after 24 hrs by liquid-phase turbidimetric system1999Journal of natural products, May, Volume: 62, Issue:5
Antifungal metabolites from the marine sponge Pachastrissa sp.: new bengamide and bengazole derivatives.
AID674401Inhibition of LPS-stimulated NFkappaB activation transfected in mouse RAW264.7 cells at 20 ug/mL after 18 hrs by luciferase reporter gene assay2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
AID275978Cytotoxicity against mouse C38 cells at 7.8 ug/disk2007Journal of natural products, Jan, Volume: 70, Issue:1
A distinctive structural twist in the aminoimidazole alkaloids from a calcareous marine sponge: isolation and characterization of leucosolenamines A and B.
AID674392Inhibition of LPS-stimulated NFkappaB activation transfected in mouse RAW264.7 cells after 18 hrs by luciferase reporter gene assay2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
AID1484173Cytotoxicity against human MDA-MB-435 cells2017Journal of natural products, 03-24, Volume: 80, Issue:3
The Bengamides: A Mini-Review of Natural Sources, Analogues, Biological Properties, Biosynthetic Origins, and Future Prospects.
AID275975Selective cytotoxicity for mouse C38 cells over CFU-GM cells at 7.8 ug/disk2007Journal of natural products, Jan, Volume: 70, Issue:1
A distinctive structural twist in the aminoimidazole alkaloids from a calcareous marine sponge: isolation and characterization of leucosolenamines A and B.
AID674393Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay2012Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's5 (38.46)29.6817
2010's6 (46.15)24.3611
2020's1 (7.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
thymidine
[no description available]		2.0310pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
caprolactam
Caprolactam: Cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. Can cause local irritation.. epsilon-caprolactam : A member of the class of caprolactams that is azepane substituted by an oxo group at position 2.		2.0810caprolactamshuman blood serum metabolite
alkenes
[no description available]		2.7830
celastrol
[no description available]		2.0710monocarboxylic acid;
pentacyclic triterpenoid		anti-inflammatory drug;
antineoplastic agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Hsp90 inhibitor;
metabolite
tartaric acid
tartaric acid: RN given refers to cpd with unspecified isomeric designation. D-tartaric acid : The D-enantiomer of tartaric acid.		2.0810tartaric acidEscherichia coli metabolite
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		7.0510chalcogen;
nonmetal atom		macronutrient
bengamide b
bengamide B: isolated from a Jaspidae marine sponge; structure in first source		4.3860
ConditionIndicatedRelationship StrengthStudiesTrials