Page last updated: 2024-12-08
alpha-methylmethionine
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Cross-References
ID Source | ID |
---|---|
PubMed CID | 135729 |
CHEMBL ID | 49574 |
CHEBI ID | 191230 |
SCHEMBL ID | 162014 |
MeSH ID | M0280967 |
Synonyms (26)
Synonym |
---|
methionine, 2-methyl- |
ALPHA-METHYLMETHIONINE , |
2-methylmethionine |
CHEMBL49574 |
562-48-1 |
(2s)-2-amino-2-methyl-4-methylsulanylbutanoic acid |
CHEBI:191230 |
(2s)-2-amino-2-methyl-4-methylsulfanylbutanoic acid |
59013-75-1 |
SCHEMBL162014 |
AB76378 |
(2s)-2-amino-2-methyl-4-(methylsulfanyl)butanoic acid |
2-methyl-l-methionine |
l-.alpha.-methylmethionine |
l-isovaline, 4-(methylthio)- |
JOJ65K4Z4S , |
(s)-(+)-2-methylmethionine |
.alpha.-methyl-l-methionine |
l-methionine, 2-methyl- |
l-alpha-methylmethionine |
alpha-methyl-l-methionine |
unii-joj65k4z4s |
(s)-2-amino-2-methyl-4-(methylthio)butanoic acid |
Q27281610 |
l-isovaline,4-(methylthio)-(9ci) |
(s)-2-amino-2-methyl-4-(methylthio)butanoicacid |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (1)
Class | Description |
---|---|
D-alpha-amino acid | |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein Targets (2)
Other Measurements
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
S-adenosylmethionine synthase isoform type-2 | Rattus norvegicus (Norway rat) | Km | 21,000.0000 | 5.0000 | 5.0000 | 5.0000 | AID107590 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Bioassays (7)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID230665 | Ratio of Vmax of normal tissue (M-T) form of rat methionine Adenosyltransferase to that of KM of normal tissue(M-T)form of rat methionine Adenosyltransferase | 1986 | Journal of medicinal chemistry, Sep, Volume: 29, Issue:9 | Isozyme-specific enzyme inhibitors. 12. C- and N-methylmethionines as substrates and inhibitors of methionine adenosyltransferases of normal and hepatoma rat tissues. |
AID107756 | Substrate activity as rate of conversion of [C14]-ATP to [C14]-Adomet in relation to KM value of methionine with M-T of rat methionine adenosyltransferase | 1986 | Journal of medicinal chemistry, Sep, Volume: 29, Issue:9 | Isozyme-specific enzyme inhibitors. 12. C- and N-methylmethionines as substrates and inhibitors of methionine adenosyltransferases of normal and hepatoma rat tissues. |
AID107911 | Substrate activity of compound (4 mM) measured as the rate of conversion of [C14]-ATP to [C14]-Adomet in relation to KM value of methionine rat Methionine adenosyltransferase II | 1986 | Journal of medicinal chemistry, Sep, Volume: 29, Issue:9 | Isozyme-specific enzyme inhibitors. 12. C- and N-methylmethionines as substrates and inhibitors of methionine adenosyltransferases of normal and hepatoma rat tissues. |
AID107585 | Compound (3 mM) was tested for the inhibition of conversion of [14C]methionine to [14C]-AdoMet by M-T (hepatoma tissue) of rat methionine adenosyltransferase | 1986 | Journal of medicinal chemistry, Sep, Volume: 29, Issue:9 | Isozyme-specific enzyme inhibitors. 12. C- and N-methylmethionines as substrates and inhibitors of methionine adenosyltransferases of normal and hepatoma rat tissues. |
AID107754 | Substrate level that produces half the maximal velocity(M-T) of rat methionine adenosyltransferase | 1986 | Journal of medicinal chemistry, Sep, Volume: 29, Issue:9 | Isozyme-specific enzyme inhibitors. 12. C- and N-methylmethionines as substrates and inhibitors of methionine adenosyltransferases of normal and hepatoma rat tissues. |
AID107590 | Substrate activity with normal tissue (M-T) form of rat methionine adenosyltransferase | 1986 | Journal of medicinal chemistry, Sep, Volume: 29, Issue:9 | Isozyme-specific enzyme inhibitors. 12. C- and N-methylmethionines as substrates and inhibitors of methionine adenosyltransferases of normal and hepatoma rat tissues. |
AID107770 | Compound (3 mM) was tested for the inhibition of conversion of [14C]methionine to [14C]AdoMet by rat Methionine adenosyltransferase II | 1986 | Journal of medicinal chemistry, Sep, Volume: 29, Issue:9 | Isozyme-specific enzyme inhibitors. 12. C- and N-methylmethionines as substrates and inhibitors of methionine adenosyltransferases of normal and hepatoma rat tissues. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (5)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 1 (20.00) | 18.7374 |
1990's | 2 (40.00) | 18.2507 |
2000's | 2 (40.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.74
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.74) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |