Page last updated: 2024-11-08

6-fluorouracil

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

6-fluorouracil: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID352912
CHEMBL ID4854670
SCHEMBL ID1896344
SCHEMBL ID8642285
MeSH IDM0107771

Synonyms (18)

Synonym
591-36-6
nsc528881
nsc-528881
6-fluorouracil
6-fluoro-1h-pyrimidine-2,4-dione
SCHEMBL1896344
AKOS006242761
6-fluoropyrimidine-2,4(1h,3h)-dione
SCHEMBL8642285
nsc 528881
2,4(1h,3h)-pyrimidinedione, 6-fluoro-
9h-purine,6-fluoro-9-b-d-ribofuranosyl-
DTXSID00326479
J-518762
FT-0707474
A869265
SB56367
CHEMBL4854670
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID1752067Induction of apoptosis in human HeLa cells assessed as early apoptotic cells measured after 12 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry2021Bioorganic & medicinal chemistry letters, 10-01, Volume: 49Design, synthesis and biological activity of bis-sulfonyl-BODIPY probes for tumor cell imaging.
AID1751942Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay2021Bioorganic & medicinal chemistry letters, 10-01, Volume: 49Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects.
AID1751940Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay2021Bioorganic & medicinal chemistry letters, 10-01, Volume: 49Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects.
AID1751941Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay2021Bioorganic & medicinal chemistry letters, 10-01, Volume: 49Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects.
AID1752063Cytotoxicity against human HeLa cells by MTT assay2021Bioorganic & medicinal chemistry letters, 10-01, Volume: 49Design, synthesis and biological activity of bis-sulfonyl-BODIPY probes for tumor cell imaging.
AID1752070Induction of apoptosis in human HeLa cells assessed as viable cells measured after 12 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry2021Bioorganic & medicinal chemistry letters, 10-01, Volume: 49Design, synthesis and biological activity of bis-sulfonyl-BODIPY probes for tumor cell imaging.
AID1751943Cytotoxicity against human H357 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay2021Bioorganic & medicinal chemistry letters, 10-01, Volume: 49Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects.
AID1752064Cytotoxicity against human L02 cells by MTT assay2021Bioorganic & medicinal chemistry letters, 10-01, Volume: 49Design, synthesis and biological activity of bis-sulfonyl-BODIPY probes for tumor cell imaging.
AID1752062Cytotoxicity against human HCT-116 cells by MTT assay2021Bioorganic & medicinal chemistry letters, 10-01, Volume: 49Design, synthesis and biological activity of bis-sulfonyl-BODIPY probes for tumor cell imaging.
AID1752068Induction of apoptosis in human HeLa cells assessed as late apoptotic cells measured after 12 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry2021Bioorganic & medicinal chemistry letters, 10-01, Volume: 49Design, synthesis and biological activity of bis-sulfonyl-BODIPY probes for tumor cell imaging.
AID1752069Induction of apoptosis in human HeLa cells assessed as necrotic cells measured after 12 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometry2021Bioorganic & medicinal chemistry letters, 10-01, Volume: 49Design, synthesis and biological activity of bis-sulfonyl-BODIPY probes for tumor cell imaging.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (28.57)18.7374
1990's2 (28.57)18.2507
2000's0 (0.00)29.6817
2010's1 (14.29)24.3611
2020's2 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (14.29%)5.53%
Reviews1 (14.29%)6.00%
Case Studies1 (14.29%)4.05%
Observational0 (0.00%)0.25%
Other4 (57.14%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]