| ID Source | ID |
|---|---|
| PubMed CID | 3033941 |
| CHEMBL ID | 1767409 |
| SCHEMBL ID | 625973 |
| MeSH ID | M0164625 |
| Synonym |
|---|
| 4-thio-utp |
| gtpl1730 |
| [(2r,3s,4r,5r)-3,4-dihydroxy-5-(2-oxo-4-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate |
| 4-thiouridine triphosphate |
| bdbm50341880 |
| ((2r,3s,4r,5r)-3,4-dihydroxy-5-(2-oxo-4-thioxo-3,4-dihydropyrimidin-1(2h)-yl)tetrahydrofuran-2-yl)methyl triphosphate |
| chembl1767409 , |
| 4-s-utp |
| uridine 5'-(tetrahydrogen triphosphate), 4-thio- |
| 31556-28-2 |
| SCHEMBL625973 |
| [[(2r,3s,4r,5r)-3,4-dihydroxy-5-(2-oxo-4-thioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate |
| 4-thiouridine 5'-triphosphate |
| Q27073960 |
| 4-THIOUTP |
| 4-thiouridine-5'-triphosphate |
| DTXSID10953533 |
| 1-[5-o-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]-4-sulfanylpyrimidin-2(1h)-one |
| PD050274 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| P2Y purinoceptor 2 | Homo sapiens (human) | EC50 (µMol) | 0.3680 | 0.0056 | 0.6828 | 10.0000 | AID1372695; AID593124 |
| P2Y purinoceptor 4 | Homo sapiens (human) | EC50 (µMol) | 0.0230 | 0.0230 | 1.3623 | 10.0000 | AID593125; AID593135 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| protein binding | P2Y purinoceptor 2 | Homo sapiens (human) |
| signaling receptor activity | P2Y purinoceptor 2 | Homo sapiens (human) |
| G protein-coupled purinergic nucleotide receptor activity | P2Y purinoceptor 2 | Homo sapiens (human) |
| A1 adenosine receptor binding | P2Y purinoceptor 2 | Homo sapiens (human) |
| G protein-coupled UTP receptor activity | P2Y purinoceptor 2 | Homo sapiens (human) |
| protein binding | P2Y purinoceptor 4 | Homo sapiens (human) |
| ATP binding | P2Y purinoceptor 4 | Homo sapiens (human) |
| G protein-coupled purinergic nucleotide receptor activity | P2Y purinoceptor 4 | Homo sapiens (human) |
| G protein-coupled UTP receptor activity | P2Y purinoceptor 4 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| plasma membrane | P2Y purinoceptor 2 | Homo sapiens (human) |
| plasma membrane | P2Y purinoceptor 2 | Homo sapiens (human) |
| plasma membrane | P2Y purinoceptor 4 | Homo sapiens (human) |
| basolateral plasma membrane | P2Y purinoceptor 4 | Homo sapiens (human) |
| apical plasma membrane | P2Y purinoceptor 4 | Homo sapiens (human) |
| presynaptic active zone membrane | P2Y purinoceptor 4 | Homo sapiens (human) |
| glutamatergic synapse | P2Y purinoceptor 4 | Homo sapiens (human) |
| plasma membrane | P2Y purinoceptor 4 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1372695 | Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as [3H]-inositol phosphate accumulation measured after 90 mins by anion exchange chromatographic method | 2018 | Bioorganic & medicinal chemistry, 01-15, Volume: 26, Issue:2 | Current knowledge on the nucleotide agonists for the P2Y2 receptor. |
| AID593135 | Agonist activity at P2Y4 receptor | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8 | Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. |
| AID593126 | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8 | Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. |
| AID593125 | Agonist activity at human recombinant P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8 | Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. |
| AID593124 | Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8 | Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. |
| AID1347028 | Human P2Y2 receptor (P2Y receptors) | 2006 | Current medicinal chemistry, , Volume: 13, Issue:3 | P2 receptors activated by uracil nucleotides--an update. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.57) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (15.38%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (84.62%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||