Page last updated: 2024-12-06

2,2',3,3',4,6'-hexachlorobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,2',3,3',4,6'-hexachlorobiphenyl, also known as PCB 153, is a highly chlorinated polychlorinated biphenyl (PCB) congener. It is a persistent organic pollutant (POP) with a long half-life in the environment. PCBs were widely used in industrial applications, such as electrical transformers and capacitors, due to their electrical insulating properties, thermal stability, and resistance to chemical degradation. However, their persistence and toxicity led to their ban in many countries. PCB 153 has been shown to be toxic to various organisms, including fish, birds, and mammals. It can accumulate in the food chain and has been associated with adverse health effects in humans, including reproductive problems, cancer, and neurodevelopmental disorders. Research on PCB 153 focuses on its environmental fate, toxicity, and potential health risks. Understanding its properties and behavior is crucial for developing strategies to mitigate its environmental and health impacts.'

2,2',3,3',4,6'-hexachlorobiphenyl: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID38017
SCHEMBL ID4453307
MeSH IDM0249855

Synonyms (20)

Synonym
1,1'-biphenyl, 2,2',3,3',4,6'-hexachloro-
2,2',3,3',4,6'-hexachloro-1,1'-biphenyl
pcb 132
gpcb 132
2,2',3,3',4,6'-hexachlorobiphenyl
38380-05-1
1,2,3-trichloro-4-(2,3,6-trichlorophenyl)benzene
814t8d9w95 ,
unii-814t8d9w95
2,2,3,3,4,6-hexachloro-1,1-biphenyl
SCHEMBL4453307
OKBJVIVEFXPEOU-UHFFFAOYSA-N
2,2',3,3',4,6'-hexachloro-1,1'-biphenyl #
DTXSID9074141 ,
pcb no. 132 10 microg/ml in isooctane
pcb no. 132
3-(carboxymethyl)benzothiazoliumbromide
Q27269208
CS-0451960
dtxcid5039486

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" CB 132 (2,2',3,3',4,6'-hexachlorophenyl) and CB 149 (2,2'3,4',5',6-hexachlorophenyl) were investigated in weanling female rats dosed intraperitoneally on days 21 and 22 and killed on day 24 of age."( Hepatic enzyme induction and acute endocrine effects of 2,2',3,3',4,6'-hexachlorobiphenyl and 2,2',3,4',5',6-hexachlorobiphenyl in prepubertal female rats.
Guo, YL; Hsu, PC; Li, MH, 2001
)
0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's6 (85.71)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.96

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.96 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index5.04 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.96)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]