## 19-Norcorticosterone: A Research Tool for Understanding Corticosteroid Action
19-Norcorticosterone is a synthetic steroid closely related to the naturally occurring hormone **corticosterone**. It is considered a **selective glucocorticoid receptor (GR) agonist**, meaning it binds to and activates GRs with high affinity, while having minimal affinity for other steroid receptors like the mineralocorticoid receptor (MR).
**Here's why 19-norcorticosterone is important for research:**
**1. Studying Glucocorticoid Receptor Function:**
* **Selective Activation:** 19-norcorticosterone's specific action on GRs allows researchers to study the effects of glucocorticoids without the confounding effects of MR activation. This is crucial for understanding the specific role of GRs in various biological processes.
* **Pharmacological Tool:** 19-norcorticosterone is used as a research tool to investigate the mechanisms and consequences of GR activation in different cellular contexts.
* **Understanding Glucocorticoid Resistance:** By comparing the effects of 19-norcorticosterone with corticosterone, researchers can assess the presence and mechanisms of glucocorticoid resistance in different disease models.
**2. Therapeutic Potential:**
* **Potential for Drug Development:** 19-norcorticosterone's selective GR agonism has potential for developing new therapeutic strategies for conditions where targeting GRs is beneficial. This includes inflammatory disorders, autoimmune diseases, and certain types of cancer.
* **Improved Safety Profile:** Due to its minimal MR affinity, 19-norcorticosterone might offer a safer therapeutic profile compared to conventional glucocorticoids, which often cause side effects related to MR activation.
**3. Studying Corticosteroid Metabolism:**
* **Investigating Metabolic Pathways:** 19-norcorticosterone can be used to study the metabolic pathways involved in corticosteroid synthesis and breakdown. Understanding these pathways is crucial for developing new drugs that can modulate corticosteroid levels.
**In summary, 19-norcorticosterone is a valuable tool for researchers investigating the diverse roles of glucocorticoids in the body. Its selective GR agonism and potential therapeutic applications make it a promising candidate for future drug development and research advancements.**
**Note:** This information is for educational purposes only. Consult with a medical professional for any health concerns or treatment options.
| ID Source | ID |
|---|---|
| PubMed CID | 165276 |
| SCHEMBL ID | 11044964 |
| MeSH ID | M0089364 |
| Synonym |
|---|
| 19-norcorticosterone |
| 4889-84-3 |
| (8s,9s,10r,11s,13s,14s,17s)-11-hydroxy-17-(2-hydroxyacetyl)-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one |
| 19-norpregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)- |
| 18-deoxy-19-noraldosterone |
| SCHEMBL11044964 |
| DTXSID40964132 |
| 11,21-dihydroxy-19-norpregn-4-ene-3,20-dione |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.75) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (20.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||