12-hydroxy-5,8,14-eicosatrienoic acid profile

12-hydroxy-5,8,14-eicosatrienoic acid, also known as **12-HETE**, is a **metabolite** of arachidonic acid, a fatty acid found in cell membranes. It's a **hydroxylated eicosanoid** that plays a role in various physiological processes, making it an important subject of research.

**Here's why 12-HETE is important for research:**

* **Inflammation:** 12-HETE is involved in both **pro-inflammatory** and **anti-inflammatory** pathways. It can:
* **Promote inflammation:** by activating neutrophils, platelets, and mast cells, contributing to the inflammatory response in various tissues.
* **Suppress inflammation:** by inhibiting the production of other pro-inflammatory molecules like leukotrienes.
* **Cell growth and proliferation:** 12-HETE has been shown to **stimulate** cell growth and proliferation in certain cell types, including cancer cells.
* **Blood vessel function:** 12-HETE can affect **blood vessel constriction and dilation**, potentially influencing blood pressure and cardiovascular health.
* **Nervous system function:** 12-HETE plays a role in **neuronal signaling and neuroprotection**, potentially impacting cognitive function and neurological disorders.
* **Immune response:** 12-HETE is involved in modulating **immune responses** to pathogens and allergens, potentially influencing the development of allergies and autoimmune diseases.

**Research on 12-HETE focuses on various aspects, including:**

* **Understanding its role in different diseases:** Researchers are investigating how 12-HETE contributes to the development and progression of diseases such as inflammation, cancer, cardiovascular disease, and neurodegenerative disorders.
* **Developing therapeutic targets:** 12-HETE's involvement in various pathways makes it a potential target for drug development. Research aims to identify compounds that can modulate 12-HETE production or signaling, potentially leading to new therapies for a range of diseases.
* **Investigating its mechanism of action:** Researchers are exploring the precise mechanisms by which 12-HETE exerts its biological effects, aiming to understand its interactions with various cellular components and signaling pathways.

**Overall, 12-HETE is a complex molecule with diverse biological functions. Its importance in research lies in its potential to shed light on the pathogenesis of various diseases and provide new therapeutic targets for drug development.**

12-hydroxy-5,8,14-eicosatrienoic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	5283149
CHEMBL ID	329415
CHEBI ID	184584
SCHEMBL ID	1476546
MeSH ID	M0185016

Synonym
CHEMBL329415
12(r)dh-hete
5,8,14-eicosatrienoic acid, 12-hydroxy-, (r-(z,z,z))-
12-hydroxy-5,8,14-eicosatrienoic acid
12r-hydroxy-5z,8z,12z-eicosatrienoic acid
LMFA03050012 ,
12r-hetre
(5z,8z,12r,14z)-12-hydroxyicosa-5,8,14-trienoic acid
117346-20-0
CHEBI:184584
SCHEMBL1476546
12-hydroxy-5,8,14-eicosatrienoic acid, (z,z,z)-isomer
12r-hydroxy-5z,8z,12z-eicosatrienoate
12-hydroxy-5,8,14-eicosatrienoic acid, (s-(z,z,z))-isomer

Class	Description
hydroxy fatty acid	Any fatty acid carrying one or more hydroxy substituents.
polyunsaturated fatty acid	Any fatty acid containing more than one double bond. Acids in this group are reported to have cardioprotective effects; and levels are lowered in chronic fatigue syndrome.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	6 (60.00)	18.2507
2000's	4 (40.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (10.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (90.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
clotrimazole [no description available]	1.98	1	conazole antifungal drug; imidazole antifungal drug; imidazoles; monochlorobenzenes	antiinfective agent; environmental contaminant; xenobiotic
proadifen Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.	1.98	1	diarylmethane
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	1.98	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	9	4	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
nadp [no description available]	2.41	2
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
8,11,14-eicosatrienoic acid 8,11,14-Eicosatrienoic Acid: A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.. all-cis-icosa-8,11,14-trienoic acid : An icosatrienoic acid having three cis double bonds at positions 8, 11 and 14.	4.8	10	fatty acid 20:3; long-chain fatty acid	fungal metabolite; human metabolite; nutraceutical
12-hydroxy-5,8,10,14-eicosatetraenoic acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid: A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)	4.47	7

Condition	Relationship Strength	Studies
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.01	1
Injuries, Eye [description not available]	2.01	1
Innate Inflammatory Response [description not available]	2.41	2
Burns Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.	2.01	1
Eye Injuries Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.	2.01	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.41	2
Corneal Angiogenesis [description not available]	2.4	2
Corneal Neovascularization New blood vessels originating from the corneal blood vessels and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.	2.4	2
Delayed Hypersensitivity [description not available]	1.98	1
Dermatitis Any inflammation of the skin.	1.98	1
Erythema Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.	1.98	1
Anoxemia [description not available]	2	1
Hypoxia Sub-optimal OXYGEN levels in the ambient air of living organisms.	2	1
Pink Eye [description not available]	1.98	1
Conjunctivitis INFLAMMATION of the CONJUNCTIVA.	1.98	1

12-hydroxy-5,8,14-eicosatrienoic acid

Description

Cross-References

Synonyms (14)

Drug Classes (2)

Research

Studies (10)

Market Indicators

Research Demand Index: 11.84

Study Types