Page last updated: 2024-11-13
palmostatin m
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
palmostatin M: inhibits acyl protein thioesterases 1 and 2; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 56641205 |
| CHEMBL ID | 3133031 |
| MeSH ID | M0582002 |
Synonyms (3)
| Synonym |
|---|
| CHEMBL3133031 , |
| bdbm50496629 |
| palmostatin m |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (2)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Acyl-protein thioesterase 1 | Homo sapiens (human) | IC50 (µMol) | 0.0025 | 0.0025 | 1.1761 | 3.5500 | AID1079563 |
| Acyl-protein thioesterase 2 | Homo sapiens (human) | IC50 (µMol) | 0.0196 | 0.0196 | 1.2873 | 3.5500 | AID1079562 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (8)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| protein depalmitoylation | Acyl-protein thioesterase 1 | Homo sapiens (human) |
| fatty acid metabolic process | Acyl-protein thioesterase 1 | Homo sapiens (human) |
| fatty acid transport | Acyl-protein thioesterase 1 | Homo sapiens (human) |
| negative regulation of Golgi to plasma membrane protein transport | Acyl-protein thioesterase 1 | Homo sapiens (human) |
| negative regulation of aggrephagy | Acyl-protein thioesterase 1 | Homo sapiens (human) |
| protein depalmitoylation | Acyl-protein thioesterase 2 | Homo sapiens (human) |
| fatty acid metabolic process | Acyl-protein thioesterase 2 | Homo sapiens (human) |
| axon guidance | Acyl-protein thioesterase 2 | Homo sapiens (human) |
| acylglycerol catabolic process | Acyl-protein thioesterase 2 | Homo sapiens (human) |
| prostaglandin catabolic process | Acyl-protein thioesterase 2 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Molecular Functions (7)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| phospholipase activity | Acyl-protein thioesterase 1 | Homo sapiens (human) |
| lysophospholipase activity | Acyl-protein thioesterase 1 | Homo sapiens (human) |
| protein binding | Acyl-protein thioesterase 1 | Homo sapiens (human) |
| palmitoyl-(protein) hydrolase activity | Acyl-protein thioesterase 1 | Homo sapiens (human) |
| lipase activity | Acyl-protein thioesterase 1 | Homo sapiens (human) |
| carboxylic ester hydrolase activity | Acyl-protein thioesterase 1 | Homo sapiens (human) |
| lysophospholipase activity | Acyl-protein thioesterase 2 | Homo sapiens (human) |
| protein binding | Acyl-protein thioesterase 2 | Homo sapiens (human) |
| palmitoyl-(protein) hydrolase activity | Acyl-protein thioesterase 2 | Homo sapiens (human) |
| cadherin binding | Acyl-protein thioesterase 2 | Homo sapiens (human) |
| carboxylic ester hydrolase activity | Acyl-protein thioesterase 2 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Ceullar Components (8)
Bioassays (3)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1079563 | Inhibition of APT1 (unknown origin) | 2014 | MedChemComm, Mar, Volume: 5, Issue:3 | Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation. |
| AID1206942 | Inhibition of Staphylococcus aureus caseinolytic protein protease using fluorogenic substrate assessed as residual activity at 10 uM after 15 mins | 2015 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11 | De novo design of caseinolytic protein proteases inhibitors based on pharmacophore and 2D molecular fingerprints. |
| AID1079562 | Inhibition of APT2 (unknown origin) | 2014 | MedChemComm, Mar, Volume: 5, Issue:3 | Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.80
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.80) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||