Compounds > palmostatin m
Page last updated: 2024-11-13

palmostatin m

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

palmostatin M: inhibits acyl protein thioesterases 1 and 2; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID56641205
CHEMBL ID3133031
MeSH IDM0582002

Synonyms (3)

Synonym
CHEMBL3133031 ,
bdbm50496629
palmostatin m
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Acyl-protein thioesterase 1Homo sapiens (human)IC50 (µMol)0.00250.00251.17613.5500AID1079563
Acyl-protein thioesterase 2Homo sapiens (human)IC50 (µMol)0.01960.01961.28733.5500AID1079562
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (8)

Processvia Protein(s)Taxonomy
protein depalmitoylationAcyl-protein thioesterase 1Homo sapiens (human)
fatty acid metabolic processAcyl-protein thioesterase 1Homo sapiens (human)
fatty acid transportAcyl-protein thioesterase 1Homo sapiens (human)
negative regulation of Golgi to plasma membrane protein transportAcyl-protein thioesterase 1Homo sapiens (human)
negative regulation of aggrephagyAcyl-protein thioesterase 1Homo sapiens (human)
protein depalmitoylationAcyl-protein thioesterase 2Homo sapiens (human)
fatty acid metabolic processAcyl-protein thioesterase 2Homo sapiens (human)
axon guidanceAcyl-protein thioesterase 2Homo sapiens (human)
acylglycerol catabolic processAcyl-protein thioesterase 2Homo sapiens (human)
prostaglandin catabolic processAcyl-protein thioesterase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
phospholipase activityAcyl-protein thioesterase 1Homo sapiens (human)
lysophospholipase activityAcyl-protein thioesterase 1Homo sapiens (human)
protein bindingAcyl-protein thioesterase 1Homo sapiens (human)
palmitoyl-(protein) hydrolase activityAcyl-protein thioesterase 1Homo sapiens (human)
lipase activityAcyl-protein thioesterase 1Homo sapiens (human)
carboxylic ester hydrolase activityAcyl-protein thioesterase 1Homo sapiens (human)
lysophospholipase activityAcyl-protein thioesterase 2Homo sapiens (human)
protein bindingAcyl-protein thioesterase 2Homo sapiens (human)
palmitoyl-(protein) hydrolase activityAcyl-protein thioesterase 2Homo sapiens (human)
cadherin bindingAcyl-protein thioesterase 2Homo sapiens (human)
carboxylic ester hydrolase activityAcyl-protein thioesterase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
plasma membraneAcyl-protein thioesterase 1Homo sapiens (human)
nucleoplasmAcyl-protein thioesterase 1Homo sapiens (human)
cytoplasmAcyl-protein thioesterase 1Homo sapiens (human)
endoplasmic reticulumAcyl-protein thioesterase 1Homo sapiens (human)
cytosolAcyl-protein thioesterase 1Homo sapiens (human)
plasma membraneAcyl-protein thioesterase 1Homo sapiens (human)
nuclear membraneAcyl-protein thioesterase 1Homo sapiens (human)
extracellular exosomeAcyl-protein thioesterase 1Homo sapiens (human)
cytoplasmAcyl-protein thioesterase 1Homo sapiens (human)
nucleoplasmAcyl-protein thioesterase 2Homo sapiens (human)
cytoplasmAcyl-protein thioesterase 2Homo sapiens (human)
Golgi stackAcyl-protein thioesterase 2Homo sapiens (human)
cytosolAcyl-protein thioesterase 2Homo sapiens (human)
extracellular exosomeAcyl-protein thioesterase 2Homo sapiens (human)
cytoplasmAcyl-protein thioesterase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1079563Inhibition of APT1 (unknown origin)2014MedChemComm, Mar, Volume: 5, Issue:3
Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.
AID1206942Inhibition of Staphylococcus aureus caseinolytic protein protease using fluorogenic substrate assessed as residual activity at 10 uM after 15 mins2015Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
De novo design of caseinolytic protein proteases inhibitors based on pharmacophore and 2D molecular fingerprints.
AID1079562Inhibition of APT2 (unknown origin)2014MedChemComm, Mar, Volume: 5, Issue:3
Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.80 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
propiolactone
Propiolactone: Disinfectant used in vapor form to sterilize vaccines, grafts, etc. The vapor is very irritating and the liquid form is carcinogenic.		2.830propan-3-olide
palmostatin b
palmostatin B: inhibits acyl protein thioesterase 1; structure in first source		2.7730
ConditionIndicatedRelationship StrengthStudiesTrials