Page last updated: 2024-08-07 10:30:56

Short transient receptor potential channel 7

A short transient receptor potential cation channel TRPC7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HCX4]

Synonyms

TrpC7;
Transient receptor protein 7;
TRP-7;
hTRP7

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (1)

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-[3-(4-fluorophenyl)-2-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-5-yl]-1-piperidinecarboxylic acid ethyl esterHomo sapiens (human)EC500.813522

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
calcium channel activitymolecular functionEnables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
inositol 1,4,5 trisphosphate bindingmolecular functionBinding to inositol 1,4,5 trisphosphate. [GOC:BHF, GOC:mah]
store-operated calcium channel activitymolecular functionA ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. [GOC:dph, GOC:tb, PMID:15788710]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
nuclear envelopecellular componentThe double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [ISBN:0198547684]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
perinuclear region of cytoplasmcellular componentCytoplasm situated near, or occurring around, the nucleus. [GOC:jid]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
cation channel complexcellular componentAn ion channel complex through which cations pass. [GOC:mah]

Involved In

This protein is involved in 3 target(s):

TargetCategoryDefinition
calcium ion transmembrane transportbiological processA process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
regulation of cytosolic calcium ion concentrationbiological processAny process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. [GOC:ai, GOC:mah, GOC:rph]
single fertilizationbiological processThe union of male and female gametes to form a zygote. [GOC:ems, GOC:mtg_sensu]