A short transient receptor potential cation channel TRPC7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HCX4]
TrpC7;
Transient receptor protein 7;
TRP-7;
hTRP7
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-[3-(4-fluorophenyl)-2-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-5-yl]-1-piperidinecarboxylic acid ethyl ester | Homo sapiens (human) | EC50 | 0.8135 | 2 | 2 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| calcium channel activity | molecular function | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| inositol 1,4,5 trisphosphate binding | molecular function | Binding to inositol 1,4,5 trisphosphate. [GOC:BHF, GOC:mah] |
| store-operated calcium channel activity | molecular function | A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. [GOC:dph, GOC:tb, PMID:15788710] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| nuclear envelope | cellular component | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [ISBN:0198547684] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cation channel complex | cellular component | An ion channel complex through which cations pass. [GOC:mah] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| calcium ion transmembrane transport | biological process | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah] |
| regulation of cytosolic calcium ion concentration | biological process | Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. [GOC:ai, GOC:mah, GOC:rph] |
| single fertilization | biological process | The union of male and female gametes to form a zygote. [GOC:ems, GOC:mtg_sensu] |