Pathways > Leishmania infection
Page last updated: 2024-10-06

Leishmania infection

Proteins (66)

ProteinSynonymsTaxonomy
Interleukin-10IL-10; Cytokine synthesis inhibitory factor; CSIFHomo sapiens (human)
Actin-related protein 3Actin-like protein 3Homo sapiens (human)
Tyrosine-protein kinase ABL1EC 2.7.10.2; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150Homo sapiens (human)
Heat shock protein HSP 90-betaHSP 90; Heat shock 84 kDa; HSP 84; HSP84Homo sapiens (human)
Cathepsin GCG; EC 3.4.21.20Homo sapiens (human)
Mitogen-activated protein kinase 3 MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1Homo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
Tyrosine-protein kinase SYKEC 2.7.10.2; Spleen tyrosine kinase; p72-SykHomo sapiens (human)
Disintegrin and metalloproteinase domain-containing protein 17ADAM 17; EC 3.4.24.86; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzymeHomo sapiens (human)
Transcription factor p65Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3Homo sapiens (human)
Dedicator of cytokinesis protein 1180 kDa protein downstream of CRK; DOCK180Homo sapiens (human)
Transcription factor AP-1Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39Homo sapiens (human)
Heme oxygenase 1HO-1; EC 1.14.14.18Homo sapiens (human)
FurinEC 3.4.21.75; Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACEHomo sapiens (human)
Adenosine receptor A2bHomo sapiens (human)
Caspase-1CASP-1; EC 3.4.22.36; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45Homo sapiens (human)
Mitogen-activated protein kinase 8MAP kinase 8; MAPK 8; EC 2.7.11.24; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1Homo sapiens (human)
Cell division control protein 42 homologEC 3.6.5.2; G25K GTP-binding proteinHomo sapiens (human)
Actin-related protein 2/3 complex subunit 5Arp2/3 complex 16 kDa subunit; p16-ARCHomo sapiens (human)
S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like molecule; IP(3)Rs binding protein released with IP(3); IRBIT; Putative adenosylhomocysteinase 2; S-adenosyl-L-homocysteine hydrolase 2; AdoHcyase 2Homo sapiens (human)
Dipeptidase 1EC 3.4.13.19; Beta-lactamase; 3.5.2.6; Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase; hRDPHomo sapiens (human)
Cyclic AMP-responsive element-binding protein 1CREB-1; cAMP-responsive element-binding protein 1Homo sapiens (human)
Adapter molecule crkProto-oncogene c-Crk; p38Homo sapiens (human)
Ras-related C3 botulinum toxin substrate 1EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1Homo sapiens (human)
Dipeptidase 2EC 3.4.13.19Homo sapiens (human)
Dipeptidase 3EC 3.4.13.19Homo sapiens (human)
Myosin-9Cellular myosin heavy chain, type A; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; Non-muscle myosin heavy chain A; NMMHC-A; Non-muscle myosin heavy chain IIa; NMMHC II-a; NMMHC-IIAHomo sapiens (human)
NACHT, LRR and PYD domains-containing protein 3 Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; CLR1.1; Cold-induced autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1Homo sapiens (human)
Frizzled-7Fz-7; hFz7; FzE3Homo sapiens (human)
Ectonucleoside triphosphate diphosphohydrolase 5NTPDase 5; EC 3.6.1.6; CD39 antigen-like 4; ER-UDPase; Guanosine-diphosphatase ENTPD5; GDPase ENTPD5; 3.6.1.42; Nucleoside diphosphatase; Uridine-diphosphatase ENTPD5; UDPase ENTPD5Homo sapiens (human)
Gasdermin-DGasdermin domain-containing protein 1Homo sapiens (human)
Interleukin-6IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2Homo sapiens (human)
Calmodulin-1Homo sapiens (human)
ThioredoxinTrx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASPHomo sapiens (human)
5'-nucleotidase5'-NT; EC 3.1.3.5; Ecto-5'-nucleotidaseHomo sapiens (human)
Ectonucleoside triphosphate diphosphohydrolase 1NTPDase 1; EC 3.6.1.5; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigenHomo sapiens (human)
C3a anaphylatoxin chemotactic receptorC3AR; C3a-RHomo sapiens (human)
NADPH oxidase 1NOX-1; EC 1.-.-.-; Mitogenic oxidase 1; MOX-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NOH-1Homo sapiens (human)
Complement C3C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1Homo sapiens (human)
Glutathione hydrolase 1 proenzymeEC 3.4.19.13; Gamma-glutamyltransferase 1; Gamma-glutamyltranspeptidase 1; GGT 1; 2.3.2.2; Leukotriene-C4 hydrolase; 3.4.19.14Homo sapiens (human)
Actin-related protein 2/3 complex subunit 1BArp2/3 complex 41 kDa subunit; p41-ARCHomo sapiens (human)
Actin-related protein 2/3 complex subunit 2Arp2/3 complex 34 kDa subunit; p34-ARCHomo sapiens (human)
Protein BRICK1BRK1Homo sapiens (human)
Apoptosis-associated speck-like protein containing a CARDhASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1Homo sapiens (human)
Actin-related protein 2Actin-like protein 2Homo sapiens (human)
PyrinMarenostrinHomo sapiens (human)
Actin-related protein 2/3 complex subunit 1ASOP2-like proteinHomo sapiens (human)
Protein Wnt-5aHomo sapiens (human)
Thioredoxin-interacting proteinThioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1Homo sapiens (human)
Proline-serine-threonine phosphatase-interacting protein 1PEST phosphatase-interacting protein 1; CD2-binding protein 1; H-PIPHomo sapiens (human)
Actin-related protein 2/3 complex subunit 3Arp2/3 complex 21 kDa subunit; p21-ARCHomo sapiens (human)
Low affinity immunoglobulin gamma Fc region receptor III-ACD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2Homo sapiens (human)
Cytochrome b-245 light chainCytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phoxHomo sapiens (human)
Guanine nucleotide-binding protein G(z) subunit alphaG(x) alpha chain; Gz-alphaHomo sapiens (human)
Glutathione hydrolase 5 proenzymeEC 3.4.19.13; Gamma-glutamyl transpeptidase-related enzyme; GGT-rel; Gamma-glutamyltransferase 5; GGT 5; 2.3.2.2; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; Leukotriene-C4 hydrolase; 3.4.19.14Homo sapiens (human)
Nck-associated protein 1-likeHematopoietic protein 1; Membrane-associated protein HEM-1Homo sapiens (human)
Actin-related protein 2/3 complex subunit 4Arp2/3 complex 20 kDa subunit; p20-ARCHomo sapiens (human)
Inactive rhomboid protein 2iRhom2; Rhomboid 5 homolog 2; Rhomboid family member 2; Rhomboid veinlet-like protein 5; Rhomboid veinlet-like protein 6Homo sapiens (human)
NADPH oxidase activator 1NOX activator 1; Antigen NY-CO-31; NCF2-like protein; P67phox-like factor; p51-noxHomo sapiens (human)
Scavenger receptor cysteine-rich type 1 protein M130Hemoglobin scavenger receptorHomo sapiens (human)
NADPH oxidase organizer 1NADPH oxidase regulatory protein; Nox organizer 1; Nox-organizing protein 1; SH3 and PX domain-containing protein 5Homo sapiens (human)
Unconventional myosin-XUnconventional myosin-10Homo sapiens (human)
Brain-specific angiogenesis inhibitor 1-associated protein 2BAI-associated protein 2; BAI1-associated protein 2; Protein BAP2; Fas ligand-associated factor 3; FLAF3; Insulin receptor substrate p53/p58; IRS-58; IRSp53/58; Insulin receptor substrate protein of 53 kDa; IRSp53; Insulin receptor substrate p53Homo sapiens (human)
Nck-associated protein 1NAP 1; Membrane-associated protein HEM-2; p125Nap1Homo sapiens (human)
Protein SGT1 homologProtein 40-6-3; Sgt1; Suppressor of G2 allele of SKP1 homologHomo sapiens (human)
Putative GIPL galf transferase Leishmania major

Compounds (22)

CompoundDescription
hydronium ion
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
SuperoxidesHighly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.
adenosineA nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
nicotinamide-beta-riboside
leukotriene c4The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)
leukotriene d4One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990)
leukotriene e4A biologically active principle of SRS-A that is formed from LEUKOTRIENE D4 via a peptidase reaction that removes the glycine residue. The biological actions of LTE4 are similar to LTC4 and LTD4. (From Dictionary of Prostaglandins and Related Compounds, 1990)
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
cyclic ampAn adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
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