Page last updated: 2024-10-06

HIV Life Cycle

Proteins (127)

ProteinSynonymsTaxonomy
PC4 and SFRS1-interacting proteinCLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; Transcriptional coactivator p75/p52Homo sapiens (human)
Barrier-to-autointegration factorBreakpoint cluster region protein 1Homo sapiens (human)
Gag-Pol polyproteinPr160Gag-PolHIV-1 M:B_HXB2R
Transcription initiation factor IIA subunit 1General transcription factor IIA subunit 1; TFIIAL; Transcription initiation factor TFIIA 42 kDa subunit; TFIIA-42Homo sapiens (human)
Cyclin-dependent kinase 7EC 2.7.11.22; EC 2.7.11.23; 39 kDa protein kinase; p39 Mo15; CDK-activating kinase 1; Cell division protein kinase 7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunitHomo sapiens (human)
Cyclin-dependent kinase 9EC 2.7.11.22; EC 2.7.11.23; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunitHomo sapiens (human)
Cyclin-HMO15-associated protein; p34; p37Homo sapiens (human)
Protein RevART/TRS; Anti-repression transactivator; Regulator of expression of viral proteinsHIV-1 M:B_HXB2R
General transcription and DNA repair factor IIH helicase subunit XPBTFIIH subunit XPB; EC 3.6.4.12; Basic transcription factor 2 89 kDa subunit; BTF2 p89; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; TFIIH basal transcription factor complex 89 kDa subunit; TFIIH 89 kDa subunit; TFIIH p8Homo sapiens (human)
Transcription initiation factor TFIID subunit 11TFIID subunit p30-beta; Transcription initiation factor TFIID 28 kDa subunit; TAF(II)28; TAFII-28; TAFII28Homo sapiens (human)
Transcription initiation factor TFIID subunit 3140 kDa TATA box-binding protein-associated factor; TBP-associated factor 3; Transcription initiation factor TFIID 140 kDa subunit; TAF(II)140; TAF140; TAFII-140; TAFII140Homo sapiens (human)
Cyclin-T1CycT1; Cyclin-THomo sapiens (human)
FurinEC 3.4.21.75; Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACEHomo sapiens (human)
DNA repair protein XRCC4X-ray repair cross-complementing protein 4Homo sapiens (human)
Exportin-1Exp1; Chromosome region maintenance 1 protein homologHomo sapiens (human)
Protein TatTransactivating regulatory proteinHIV-1 M:B_HXB2R
T-cell surface glycoprotein CD4T-cell surface antigen T4/Leu-3Homo sapiens (human)
Elongin-CEloC; Elongin 15 kDa subunit; RNA polymerase II transcription factor SIII subunit C; SIII p15; Transcription elongation factor B polypeptide 1Homo sapiens (human)
Glycylpeptide N-tetradecanoyltransferase 2EC 2.3.1.97; Myristoyl-CoA:protein N-myristoyltransferase 2; NMT 2; Peptide N-myristoyltransferase 2; Type II N-myristoyltransferaseHomo sapiens (human)
Envelope glycoprotein gp160Env polyproteinHIV-1 M:B_HXB2R
DNA ligase 1EC 6.5.1.1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1Homo sapiens (human)
Glycylpeptide N-tetradecanoyltransferase 1EC 2.3.1.97; Myristoyl-CoA:protein N-myristoyltransferase 1; NMT 1; Type I N-myristoyltransferase; Peptide N-myristoyltransferase 1Homo sapiens (human)
Peptidyl-prolyl cis-trans isomerase A PPIase A; EC 5.2.1.8; Cyclophilin A; Cyclosporin A-binding protein; Rotamase AHomo sapiens (human)
Tumor susceptibility gene 101 proteinESCRT-I complex subunit TSG101Homo sapiens (human)
Flap endonuclease 1FEN-1; EC 3.1.-.-; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1Homo sapiens (human)
General transcription and DNA repair factor IIH helicase subunit XPDTFIIH subunit XPD; EC 3.6.4.12; Basic transcription factor 2 80 kDa subunit; BTF2 p80; CXPD; DNA excision repair protein ERCC-2; DNA repair protein complementing XP-D cells; TFIIH basal transcription factor complex 80 kDa subunit; TFIIH 80 kDa subunit; TFHomo sapiens (human)
Ran GTPase-activating protein 1RanGAP1Homo sapiens (human)
E3 SUMO-protein ligase RanBP2EC 2.3.2.-; 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2; RanBP2; p270Homo sapiens (human)
Virion infectivity factorVif; SOR proteinHIV-1 M:B_HXB2R
Vacuolar protein sorting-associated protein 4BEC 3.6.4.6; Cell migration-inducing gene 1 protein; Suppressor of K(+) transport growth defect 1; Protein SKD1Homo sapiens (human)
CDK-activating kinase assembly factor MAT1CDK7/cyclin-H assembly factor; Cyclin-G1-interacting protein; Menage a trois; RING finger protein 66; RING finger protein MAT1; p35; p36Homo sapiens (human)
Elongin-BEloB; Elongin 18 kDa subunit; RNA polymerase II transcription factor SIII subunit B; SIII p18; Transcription elongation factor B polypeptide 2Homo sapiens (human)
mRNA cap guanine-N7 methyltransferaseEC 2.1.1.56; RG7MT1; mRNA (guanine-N(7)-)-methyltransferase; mRNA cap methyltransferase; hCMT1; hMet; hcm1pHomo sapiens (human)
Nuclear pore complex protein Nup155155 kDa nucleoporin; Nucleoporin Nup155Homo sapiens (human)
X-ray repair cross-complementing protein 6EC 3.6.4.-; EC 4.2.99.-; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNAHomo sapiens (human)
GTP-binding nuclear protein RanAndrogen receptor-associated protein 24; GTPase Ran; Ras-like protein TC4; Ras-related nuclear proteinHomo sapiens (human)
Transcription elongation factor SPT5hSPT5; DRB sensitivity-inducing factor 160 kDa subunit; DSIF p160; DRB sensitivity-inducing factor large subunit; DSIF large subunit; Tat-cotransactivator 1 protein; Tat-CT1 proteinHomo sapiens (human)
DNA-directed RNA polymerase II subunit RPB1RNA polymerase II subunit B1; EC 2.7.7.6; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; RNA-directed RNA polymerase II subunit RPB1; 2.7.7.48Homo sapiens (human)
X-ray repair cross-complementing protein 5EC 3.6.4.-; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; Ku80; Ku86; Lupus Ku autoantigen protein p86; NuHomo sapiens (human)
DNA ligase 4EC 6.5.1.1; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4Homo sapiens (human)
Ran-specific GTPase-activating proteinRan-binding protein 1; RanBP1Homo sapiens (human)
Charged multivesicular body protein 6Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20Homo sapiens (human)
Charged multivesicular body protein 5Chromatin-modifying protein 5; SNF7 domain-containing protein 2; Vacuolar protein sorting-associated protein 60; Vps60; hVps60Homo sapiens (human)
Vacuolar protein sorting-associated protein VTA1 homologDopamine-responsive gene 1 protein; DRG-1; LYST-interacting protein 5; LIP5; SKD1-binding protein 1; SBP1Homo sapiens (human)
RNA polymerase II elongation factor ELLEleven-nineteen lysine-rich leukemia proteinHomo sapiens (human)
Nuclear pore complex protein Nup8888 kDa nucleoporin; Nucleoporin Nup88Homo sapiens (human)
Vacuolar protein sorting-associated protein 4AEC 3.6.4.6; Protein SKD2; VPS4-1; hVPS4Homo sapiens (human)
Nuclear cap-binding protein subunit 220 kDa nuclear cap-binding protein; Cell proliferation-inducing gene 55 protein; NCBP 20 kDa subunit; CBP20; NCBP-interacting protein 1; NIP1Homo sapiens (human)
Importin subunit alpha-5Karyopherin subunit alpha-1; Nucleoprotein interactor 1; NPI-1; RAG cohort protein 2; SRP1-betaHomo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC4RNA polymerases I, II, and III subunit ABC4; ABC10-alpha; DNA-directed RNA polymerase II subunit K; RNA polymerase II 7.0 kDa subunit; RPB7.0; RPB10alphaHomo sapiens (human)
mRNA export factorRae1 protein homolog; mRNA-associated protein mrnp 41Homo sapiens (human)
Nuclear pore membrane glycoprotein 210Nuclear pore protein gp210; Nuclear envelope pore membrane protein POM 210; POM210; Nucleoporin Nup210; Pore membrane protein of 210 kDaHomo sapiens (human)
Transcription initiation factor TFIID subunit 4RNA polymerase II TBP-associated factor subunit C; TBP-associated factor 4; Transcription initiation factor TFIID 130 kDa subunit; TAF(II)130; TAFII-130; TAFII130; Transcription initiation factor TFIID 135 kDa subunit; TAF(II)135; TAFII-135; TAFII135Homo sapiens (human)
Nucleoporin NUP42NLP-1; NUP42 homolog; Nucleoporin hCG1; Nucleoporin-42; Nucleoporin-like protein 2Homo sapiens (human)
DNA-directed RNA polymerase II subunit RPB4RNA polymerase II subunit B4; DNA-directed RNA polymerase II subunit D; RNA polymerase II 16 kDa subunit; RPB16Homo sapiens (human)
mRNA-capping enzymeHCAP1; HCEHomo sapiens (human)
Nucleoprotein TPRMegator; NPC-associated intranuclear protein; Translocated promoter region proteinHomo sapiens (human)
General transcription factor IIF subunit 2EC 3.6.4.12; ATP-dependent helicase GTF2F2; General transcription factor IIF 30 kDa subunit; Transcription initiation factor IIF subunit beta; TFIIF-beta; Transcription initiation factor RAP30Homo sapiens (human)
High mobility group protein HMG-I/HMG-YHMG-I(Y); High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein RHomo sapiens (human)
Negative elongation factor ENELF-E; RNA-binding protein RDHomo sapiens (human)
Regulator of chromosome condensationCell cycle regulatory protein; Chromosome condensation protein 1Homo sapiens (human)
DNA-directed RNA polymerase II subunit RPB3RNA polymerase II subunit 3; RNA polymerase II subunit B3; DNA-directed RNA polymerase II 33 kDa polypeptide; RPB33; DNA-directed RNA polymerase II subunit C; RPB31Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC1RNA polymerases I, II, and III subunit ABC1; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerase II subunit E; RPB5 homolog; XAP4Homo sapiens (human)
TATA-box-binding proteinTATA sequence-binding protein; TATA-binding factor; TATA-box factor; Transcription initiation factor TFIID TBP subunitHomo sapiens (human)
Transcription elongation factor A protein 1Transcription elongation factor S-II protein 1; Transcription elongation factor TFIIS.oHomo sapiens (human)
General transcription factor IIE subunit 1General transcription factor IIE 56 kDa subunit; Transcription initiation factor IIE subunit alpha; TFIIE-alphaHomo sapiens (human)
Transcription initiation factor IIE subunit betaTFIIE-beta; General transcription factor IIE subunit 2Homo sapiens (human)
DNA-directed RNA polymerase II subunit RPB2EC 2.7.7.6; DNA-directed RNA polymerase II 140 kDa polypeptide; DNA-directed RNA polymerase II subunit B; RNA polymerase II subunit 2; RNA polymerase II subunit B2Homo sapiens (human)
General transcription factor IIH subunit 1Basic transcription factor 2 62 kDa subunit; BTF2 p62; General transcription factor IIH polypeptide 1; TFIIH basal transcription factor complex p62 subunitHomo sapiens (human)
General transcription factor IIF subunit 1General transcription factor IIF 74 kDa subunit; Transcription initiation factor IIF subunit alpha; TFIIF-alpha; Transcription initiation factor RAP74Homo sapiens (human)
Nuclear pore complex protein Nup214214 kDa nucleoporin; Nucleoporin Nup214; Protein CANHomo sapiens (human)
DNA-directed RNA polymerase II subunit RPB9RNA polymerase II subunit B9; DNA-directed RNA polymerase II subunit I; RNA polymerase II 14.5 kDa subunit; RPB14.5Homo sapiens (human)
Nuclear pore glycoprotein p6262 kDa nucleoporin; Nucleoporin Nup62Homo sapiens (human)
Nuclear pore complex protein Nup153153 kDa nucleoporin; Nucleoporin Nup153Homo sapiens (human)
Transcription initiation factor TFIID subunit 6RNA polymerase II TBP-associated factor subunit E; Transcription initiation factor TFIID 70 kDa subunit; TAF(II)70; TAFII-70; TAFII70; Transcription initiation factor TFIID 80 kDa subunit; TAF(II)80; TAFII-80; TAFII80Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC3RNA polymerases I, II, and III subunit ABC3; DNA-directed RNA polymerase II subunit H; DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide; RPB17; RPB8 homolog; hRPB8Homo sapiens (human)
DNA-directed RNA polymerase II subunit RPB11-aRNA polymerase II subunit B11-a; RPB11a; DNA-directed RNA polymerase II subunit J-1; RNA polymerase II 13.3 kDa subunitHomo sapiens (human)
Transcription initiation factor IIA subunit 2General transcription factor IIA subunit 2; TFIIA p12 subunit; TFIIA-12; TFIIAS; Transcription initiation factor IIA gamma chain; TFIIA-gammaHomo sapiens (human)
Protein SEC13 homologGATOR complex protein SEC13; SEC13-like protein 1; SEC13-related proteinHomo sapiens (human)
Nuclear pore complex protein Nup107107 kDa nucleoporin; Nucleoporin Nup107Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC2RNA polymerases I, II, and III subunit ABC2; DNA-directed RNA polymerase II subunit F; DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide; RPABC14.4; RPB14.4; RPB6 homolog; RPC15Homo sapiens (human)
DNA-directed RNA polymerase II subunit RPB7RNA polymerase II subunit B7; DNA-directed RNA polymerase II subunit G; RNA polymerase II 19 kDa subunit; RPB19Homo sapiens (human)
DNA-directed RNA polymerases I, II, and III subunit RPABC5RNA polymerases I, II, and III subunit ABC5; DNA-directed RNA polymerase III subunit L; RNA polymerase II 7.6 kDa subunit; RPB7.6; RPB10 homologHomo sapiens (human)
Transcription elongation factor SPT4hSPT4; DRB sensitivity-inducing factor 14 kDa subunit; DSIF p14; DRB sensitivity-inducing factor small subunit; DSIF small subunitHomo sapiens (human)
Transcription initiation factor IIBEC 2.3.1.48; General transcription factor TFIIB; S300-IIHomo sapiens (human)
FACT complex subunit SSRP1Chromatin-specific transcription elongation factor 80 kDa subunit; Facilitates chromatin transcription complex 80 kDa subunit; FACT 80 kDa subunit; FACTp80; Facilitates chromatin transcription complex subunit SSRP1; Recombination signal sequence recognitiHomo sapiens (human)
Nuclear cap-binding protein subunit 180 kDa nuclear cap-binding protein; CBP80; NCBP 80 kDa subunitHomo sapiens (human)
Nuclear pore complex protein Nup160160 kDa nucleoporin; Nucleoporin Nup160Homo sapiens (human)
Transcription initiation factor TFIID subunit 10STAF28; Transcription initiation factor TFIID 30 kDa subunit; TAF(II)30; TAFII-30; TAFII30Homo sapiens (human)
General transcription factor IIH subunit 2Basic transcription factor 2 44 kDa subunit; BTF2 p44; General transcription factor IIH polypeptide 2; TFIIH basal transcription factor complex p44 subunitHomo sapiens (human)
General transcription factor IIH subunit 3Basic transcription factor 2 34 kDa subunit; BTF2 p34; General transcription factor IIH polypeptide 3; TFIIH basal transcription factor complex p34 subunitHomo sapiens (human)
Transcription initiation factor TFIID subunit 5Transcription initiation factor TFIID 100 kDa subunit; TAF(II)100; TAFII-100; TAFII100Homo sapiens (human)
Transcription initiation factor TFIID subunit 13Transcription initiation factor TFIID 18 kDa subunit; TAF(II)18; TAFII-18; TAFII18Homo sapiens (human)
Transcription initiation factor TFIID subunit 12Transcription initiation factor TFIID 20/15 kDa subunits; TAFII-20/TAFII-15; TAFII20/TAFII15Homo sapiens (human)
Transcription initiation factor TFIID subunit 9RNA polymerase II TBP-associated factor subunit G; STAF31/32; Transcription initiation factor TFIID 31 kDa subunit; TAFII-31; TAFII31; Transcription initiation factor TFIID 32 kDa subunit; TAFII-32; TAFII32Homo sapiens (human)
Nucleoporin NUP188hNup188Homo sapiens (human)
Transcription initiation factor TFIID subunit 2150 kDa cofactor of initiator function; RNA polymerase II TBP-associated factor subunit B; TBP-associated factor 150 kDa; Transcription initiation factor TFIID 150 kDa subunit; TAF(II)150; TAFII-150; TAFII150Homo sapiens (human)
General transcription factor IIH subunit 5General transcription factor IIH polypeptide 5; TFB5 ortholog; TFIIH basal transcription factor complex TTD-A subunitHomo sapiens (human)
Nucleoporin p5454 kDa nucleoporinHomo sapiens (human)
Negative elongation factor C/DNELF-C/D; TH1-like proteinHomo sapiens (human)
Nuclear pore complex protein Nup9393 kDa nucleoporin; Nucleoporin Nup93Homo sapiens (human)
Nucleoporin Nup43Nup107-160 subcomplex subunit Nup43; p42Homo sapiens (human)
Nucleoporin Nup37p37; Nup107-160 subcomplex subunit Nup37Homo sapiens (human)
Nucleoporin NUP3535 kDa nucleoporin; Mitotic phosphoprotein 44; MP-44; Nuclear pore complex protein Nup53; Nucleoporin NUP53Homo sapiens (human)
Nuclear pore complex protein Nup133133 kDa nucleoporin; Nucleoporin Nup133Homo sapiens (human)
Programmed cell death 6-interacting proteinPDCD6-interacting protein; ALG-2-interacting protein 1; ALG-2-interacting protein X; Hp95Homo sapiens (human)
Charged multivesicular body protein 7Chromatin-modifying protein 7Homo sapiens (human)
Negative elongation factor BNELF-B; Cofactor of BRCA1Homo sapiens (human)
Nuclear pore complex protein Nup205205 kDa nucleoporin; Nucleoporin Nup205Homo sapiens (human)
Transcription initiation factor TFIID subunit 4BTranscription initiation factor TFIID 105 kDa subunit; TAF(II)105; TAFII-105; TAFII105Homo sapiens (human)
General transcription factor IIH subunit 4Basic transcription factor 2 52 kDa subunit; BTF2 p52; General transcription factor IIH polypeptide 4; TFIIH basal transcription factor complex p52 subunitHomo sapiens (human)
TATA-binding protein-associated factor 2N68 kDa TATA-binding protein-associated factor; TAF(II)68; TAFII68; RNA-binding protein 56Homo sapiens (human)
E3 ubiquitin-protein ligase NEDD4-like EC 2.3.2.26; HECT-type E3 ubiquitin transferase NED4L; NEDD4.2; Nedd4-2Homo sapiens (human)
Nucleoporin NDC1hNDC1; Transmembrane protein 48Homo sapiens (human)
Nuclear pore complex protein Nup8585 kDa nucleoporin; FROUNT; Nucleoporin Nup75; Nucleoporin Nup85; Pericentrin-1Homo sapiens (human)
Negative elongation factor ANELF-A; Wolf-Hirschhorn syndrome candidate 2 proteinHomo sapiens (human)
Transcription initiation factor TFIID subunit 9BNeuronal cell death-related protein 7; DN-7; Transcription initiation factor TFIID subunit 9-like; Transcription-associated factor TAFII31LHomo sapiens (human)
AladinAdracalinHomo sapiens (human)
Vacuolar protein sorting-associated protein 28 homologH-Vps28; ESCRT-I complex subunit VPS28Homo sapiens (human)
Nuclear pore complex protein Nup5050 kDa nucleoporin; Nuclear pore-associated protein 60 kDa-like; Nucleoporin Nup50Homo sapiens (human)
Charged multivesicular body protein 3Chromatin-modifying protein 3; Neuroendocrine differentiation factor; Vacuolar protein sorting-associated protein 24; hVps24Homo sapiens (human)
RNA polymerase II subunit A C-terminal domain phosphataseEC 3.1.3.16; TFIIF-associating CTD phosphataseHomo sapiens (human)
FACT complex subunit SPT16Chromatin-specific transcription elongation factor 140 kDa subunit; FACT 140 kDa subunit; FACTp140; Facilitates chromatin transcription complex subunit SPT16; hSPT16Homo sapiens (human)
Gag polyproteinPr55GagHIV-1 M:B_HXB2R
Protein VprR ORF protein; Viral protein RHIV-1 M:B_HXB2R
Protein Nef3'ORF; Negative factor; F-proteinHIV-1 M:B_HXB2R
Protein VpuU ORF protein; Viral protein UHIV-1 M:B_HXB2R

Compounds (9)

CompoundDescription
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
guanosine diphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
carbovir triphosphatemetabolite of abacavir
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
s-tetradecanoyl-coenzyme a
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Coenzyme A