A glycylpeptide N-tetradecanoyltransferase 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30419]
EC 2.3.1.97;
Myristoyl-CoA:protein N-myristoyltransferase 1;
NMT 1;
Type I N-myristoyltransferase;
Peptide N-myristoyltransferase 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sc 58272 | Homo sapiens (human) | IC50 | 28.1903 | 6 | 6 |
| maleic acid anilide | Homo sapiens (human) | IC50 | 203.0000 | 1 | 1 |
| ddd 85646 | Homo sapiens (human) | IC50 | 0.0033 | 3 | 3 |
| ddd 85646 | Homo sapiens (human) | Ki | 0.0964 | 13 | 13 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| glycylpeptide N-tetradecanoyltransferase activity | molecular function | Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide. [EC:2.3.1.97] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| peptidyl-lysine N6-myristoyltransferase activity | molecular function | Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule. [GOC:mah, PMID:1402651] |
| myristoyltransferase activity | molecular function | Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule. [GOC:ai] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| in utero embryonic development | biological process | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu] |
| N-terminal peptidyl-glycine N-myristoylation | biological process | The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine. [RESID:AA0059] |
| regulation of opsin-mediated signaling pathway | biological process | Any process that modulates the frequency, rate or extent of opsin-mediated signaling. [GOC:mah] |
| cellular ketone metabolic process | biological process | The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. [GOC:jl, ISBN:0787650153] |
| protein localization to membrane | biological process | A process in which a protein is transported to, or maintained in, a specific location in a membrane. [GOC:mah] |