A glycylpeptide N-tetradecanoyltransferase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60551]
EC 2.3.1.97;
Myristoyl-CoA:protein N-myristoyltransferase 2;
NMT 2;
Peptide N-myristoyltransferase 2;
Type II N-myristoyltransferase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sc 58272 | Homo sapiens (human) | IC50 | 28.1903 | 6 | 6 |
| ddd 85646 | Homo sapiens (human) | IC50 | 0.0030 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| glycylpeptide N-tetradecanoyltransferase activity | molecular function | Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide. [EC:2.3.1.97] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| peptidyl-lysine N6-myristoyltransferase activity | molecular function | Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule. [GOC:mah, PMID:1402651] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| host cell | cellular component | A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope. [GOC:jl] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| N-terminal peptidyl-glycine N-myristoylation | biological process | The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine. [RESID:AA0059] |
| regulation of opsin-mediated signaling pathway | biological process | Any process that modulates the frequency, rate or extent of opsin-mediated signaling. [GOC:mah] |
| intracellular transport of virus | biological process | The directed movement of a virus, or part of a virus, within the host cell. [GOC:ai, GOC:bf, GOC:jl, PMID:11733033] |