Page last updated: 2024-10-06

GnRH Signaling Pathway

Proteins (47)

ProteinSynonymsTaxonomy
Glycoprotein hormones alpha chainAnterior pituitary glycoprotein hormones common subunit alpha; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; CG-alpha; Follicle-stimulating hormone alpha chain; FSH-alpha; Follitropin alpha chain; Luteinizing hormone alpha chain; Homo sapiens (human)
Cyclic AMP-dependent transcription factor ATF-4cAMP-dependent transcription factor ATF-4; Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; Tax-responsive enhancer element-binding protein 67; TaxREB67Homo sapiens (human)
Epidermal growth factor receptorEC 2.7.10.1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1Homo sapiens (human)
RAF proto-oncogene serine/threonine-protein kinaseEC 2.7.11.1; Proto-oncogene c-RAF; cRaf; Raf-1Homo sapiens (human)
Protein kinase C beta typePKC-B; PKC-beta; EC 2.7.11.13Homo sapiens (human)
Proto-oncogene tyrosine-protein kinase SrcEC 2.7.10.2; Proto-oncogene c-Src; pp60c-src; p60-SrcHomo sapiens (human)
Protein kinase C alpha typePKC-A; PKC-alpha; EC 2.7.11.13Homo sapiens (human)
Mitogen-activated protein kinase 1MAP kinase 1; MAPK 1; EC 2.7.11.24; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2Homo sapiens (human)
Gonadotropin-releasing hormone receptorGnRH receptor; GnRH-RHomo sapiens (human)
Matrix metalloproteinase-14MMP-14; EC 3.4.24.80; MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMPHomo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 1MAP kinase kinase 1; MAPKK 1; MKK1; EC 2.7.12.2; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1Homo sapiens (human)
Mitogen-activated protein kinase kinase kinase 1EC 2.7.11.25; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1Homo sapiens (human)
Voltage-dependent L-type calcium channel subunit alpha-1CCalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2Homo sapiens (human)
Mitogen-activated protein kinase 14MAP kinase 14; MAPK 14; EC 2.7.11.24; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Stress-activated Homo sapiens (human)
Calcium/calmodulin-dependent protein kinase type II subunit alphaCaM kinase II subunit alpha; CaMK-II subunit alpha; EC 2.7.11.17Homo sapiens (human)
Voltage-dependent L-type calcium channel subunit beta-1CAB1; Calcium channel voltage-dependent subunit beta 1Homo sapiens (human)
Voltage-dependent L-type calcium channel subunit alpha-1FVoltage-gated calcium channel subunit alpha Cav1.4Homo sapiens (human)
Transcription factor AP-1Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39Homo sapiens (human)
72 kDa type IV collagenaseEC 3.4.24.24; 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2; TBE-1Homo sapiens (human)
cAMP-dependent protein kinase catalytic subunit alphaPKA C-alpha; EC 2.7.11.11Homo sapiens (human)
Mitogen-activated protein kinase 8MAP kinase 8; MAPK 8; EC 2.7.11.24; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1Homo sapiens (human)
Cell division control protein 42 homologEC 3.6.5.2; G25K GTP-binding proteinHomo sapiens (human)
Growth factor receptor-bound protein 2Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2Homo sapiens (human)
Adenylate cyclase type 1EC 4.6.1.1; ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclaseHomo sapiens (human)
Early growth response protein 1EGR-1; AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24Homo sapiens (human)
Guanine nucleotide-binding protein subunit alpha-11G alpha-11; G-protein subunit alpha-11; Guanine nucleotide-binding protein G(y) subunit alphaHomo sapiens (human)
Cytosolic phospholipase A2 betacPLA2-beta; EC 3.1.1.4; Lysophospholipase A1 group IVB; 3.1.1.5; Phospholipase A2 group IVBHomo sapiens (human)
Son of sevenless homolog 1SOS-1Homo sapiens (human)
Voltage-dependent calcium channel subunit alpha-2/delta-2Voltage-gated calcium channel subunit alpha-2/delta-2Homo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 7MAP kinase kinase 7; MAPKK 7; EC 2.7.12.2; JNK-activating kinase 2; MAPK/ERK kinase 7; MEK 7; Stress-activated protein kinase kinase 4; SAPK kinase 4; SAPKK-4; SAPKK4; c-Jun N-terminal kinase kinase 2; JNK kinase 2; JNKK 2Homo sapiens (human)
GTPase HRasEC 3.6.5.2; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21rasHomo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 3MAP kinase kinase 3; MAPKK 3; EC 2.7.12.2; MAPK/ERK kinase 3; MEK 3; Stress-activated protein kinase kinase 2; SAPK kinase 2; SAPKK-2; SAPKK2Homo sapiens (human)
Guanine nucleotide-binding protein GAdenylate cyclase-stimulating G alpha proteinHomo sapiens (human)
Voltage-dependent L-type calcium channel subunit alpha-1D Calcium channel, L type, alpha-1 polypeptide, isoform 2; Voltage-gated calcium channel subunit alpha Cav1.3Homo sapiens (human)
Phospholipase D1PLD 1; hPLD1; EC 3.1.4.4; Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1Homo sapiens (human)
Voltage-dependent L-type calcium channel subunit alpha-1SCalcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; Voltage-gated calcium channel subunit alpha Cav1.1Homo sapiens (human)
Mitogen-activated protein kinase kinase kinase 2EC 2.7.11.25; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2Homo sapiens (human)
Inositol 1,4,5-trisphosphate receptor type 1IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptorHomo sapiens (human)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1EC 3.1.4.11; PLC-154; Phosphoinositide phospholipase C-beta-1; Phospholipase C-I; PLC-I; Phospholipase C-beta-1; PLC-beta-1Homo sapiens (human)
ETS domain-containing protein Elk-1Homo sapiens (human)
Proheparin-binding EGF-like growth factorHomo sapiens (human)
Progonadoliberin-1Progonadoliberin IHomo sapiens (human)
Leucine-rich repeat-containing protein 7Densin-180; Densin; Protein LAP1Homo sapiens (human)
Alpha-actinin-4Non-muscle alpha-actinin 4Homo sapiens (human)
Follitropin subunit betaFollicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chainHomo sapiens (human)
Lutropin subunit betaLutropin beta chain; Luteinizing hormone subunit beta; LH-B; LSH-B; LSH-betaHomo sapiens (human)
Calmodulin-like protein 6Calglandulin-like proteinHomo sapiens (human)

Compounds (4)

CompoundDescription
Orthophosphate
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
arachidonic acidAn unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
Cyclic AMPAn adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.