versicolorins

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

versicolorins: see also records for versicolorin A & versicolorin C; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	159258
MeSH ID	M0047738

Synonyms (7)

Synonym
9,10-anthracenedione, 1,6,8-trihydroxy-2-(hydroxymethyl)-
versicolorins
10088-98-9
1,6,8-trihydroxy-2-(hydroxymethyl)anthracene-9,10-dione
DTXSID70143559
1402-25-1
1,6,8-trihydroxy-2-(hydroxymethyl)-9,10-dihydroanthracene-9,10-dione

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" Sensitivity to AFB1 increased with increasing age of the embryo, the model system showed a dose-response to increasing carcinogen concentrations, and one-half hour exposures appeared to be optimum for AFB1."	( Rainbow trout (Salmo gairdneri) embryos: a sensitive animal model for experimental carcinogenesis. Hendricks, JD; Loveland, PM; Nixon, JE; Scanlan, RA; Sinnhuber, RO; Wales, JH, 1980)	0.26

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	8 (57.14)	18.7374
1990's	2 (14.29)	18.2507
2000's	4 (28.57)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.57 (24.57)
Research Supply Index	2.83 (2.92)
Research Growth Index	4.40 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.57)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (6.25%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (93.75%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
nitrates Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.	1.97	1	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species
dichlorvos Dichlorvos: An organophosphorus insecticide that inhibits ACETYLCHOLINESTERASE.. dichlorvos : An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate.	1.95	1	alkenyl phosphate; dialkyl phosphate; organochlorine acaricide; organophosphate insecticide	anthelminthic drug; antibacterial agent; antifungal agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor
xanthenes Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.	2.65	3	xanthene
manganese Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.	1.95	1	elemental manganese; manganese group element atom	Escherichia coli metabolite; micronutrient
norsolorinic acid norsolorinic acid: isolated from Aspergillus parasiticus. norsolorinic acid : A polyketide that is anthraquinone bearing four hydroxy substituents at positions 1, 3, 6 and 8 as well as a hexanoyl substituent at position 2.	3.51	2	polyketide; tetrahydroxyanthraquinone	fungal metabolite
o-methylsterigmatocystin [no description available]	2.03	1	sterigmatocystins
versiconal hemiacetal acetate versiconal hemiacetal acetate: intermediate in biosynthesis of aflatoxin B1; structure in first source. versiconal hemiacetal acetate : An anthrafuran that is 2,3-dihydroanthra[2,3-b]furan-5,10-dione substituted at positions 2, 4, 6 and 8 by hydroxy groups and at position 3 by a 2-acetoxyethyl group. An intermediate in the biosynthesis of aflatoxin.	2.68	3	acetate ester; anthrafuran; lactol; palmitoyl amino acid; polyphenol	metabolite
aflatoxin b1 Aflatoxin B1: A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.. aflatoxin B1 : An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.	3.48	2	aflatoxin; aromatic ether; aromatic ketone	carcinogenic agent; human metabolite
averufin averufin: isolated from Aspergillus sp.; has antifungal activity	2.42	2	cyclic ketal; organic heteropentacyclic compound; polyketide; polyphenol	fungal metabolite
nadp [no description available]	1.97	1
sterigmatocystin [no description available]	4.32	6	sterigmatocystins	metabolite
versiconal versiconal: RN not in Chemline 7/83; structure. versiconal : A secondary metabolite that is an intermediate in the biosynthesis of afflatoxin. Can exist as both a tricyclic anthraquinone-hydroxyaldehyde form or as a tetracyclic anthrafuran form.. versiconal hemiacetal : An anthrafuran that is 2,3-dihydroanthra[2,3-b]furan-5,10-dione substituted at positions 2, 4, 6 and 8 by hydroxy groups and at position 3 by a 2-hydroxyethyl group. An intermediate in the biosynthesis of aflatoxin.	2.39	2	anthrafuran; lactol; versiconal
versiconol acetate versiconol acetate: structure given in first source; RN given refers to (-)-isomer; RN for cpd without isomeric designation not avail 2/92. (3S)-versiconol acetate : An optically active form of versiconol acetate having 3S-configuration.. versiconol acetate : An acetate ester that is the O-acetyl derivative of versiconol. An intermediate in the biosynthesis of aflatoxin.	2.42	2	versiconol acetate

Condition	Relationship Strength	Studies
Experimental Hepatoma [description not available]	1.95	1
Cancer of Liver [description not available]	1.95	1
Liver Neoplasms Tumors or cancer of the LIVER.	1.95	1

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