| Assay ID | Title | Year | Journal | Article |
|---|
| AID1719528 | Inverse agonist activity at human recombinant cannabinoid CB1 receptor expressed in HEK cells transfected with CNG assessed as increase in cAMP level measured up to 1 hr by ACTOne membrane potential dye based assay | 2021 | Bioorganic & medicinal chemistry, 03-01, Volume: 33 | Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189. |
| AID1719525 | Displacement of [3H]-CP55940 from human recombinant cannabinoid CB1 receptor expressed in HEK cell membranes incubated for 1.5 hrs by liquid scintillation counting method | 2021 | Bioorganic & medicinal chemistry, 03-01, Volume: 33 | Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189. |
| AID1719540 | Inverse agonist activity at cannabinoid CB1 receptor in human U2OS cells assessed as induction of beta-arrestin recruitment using CCF4/AM as substrate preincubated for 5 hrs followed by substrate addition and measured after 2 hrs by Tango assay | 2021 | Bioorganic & medicinal chemistry, 03-01, Volume: 33 | Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189. |
| AID1719527 | Selectivity ratio of Ki for displacement of [3H]-CP55940 from human recombinant cannabinoid CB1 receptor expressed in HEK cell membranes to displacement of [3H]-CP55940 from human recombinant cannabinoid CB2 receptor expressed in HEK cell membranes | 2021 | Bioorganic & medicinal chemistry, 03-01, Volume: 33 | Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189. |
| AID1241326 | Inverse agonist activity at CB2 receptor (unknown origin) expressed in HEK cells assessed as increase in cAMP production at 5 x 10'-6 to 5 x 10'-10 M measured at 50 mins by ACTOne dye-based fluorescence assay in presence of forskolin and Ro 20-1724 relati | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist. |
| AID1719543 | Inverse agonist activity at cannabinoid CB2 receptor in human U2OS cells assessed as emission ratio using CCF4/AM as substrate preincubated for 5 hrs followed by substrate addition and measured after 2 hrs by Tango assay | 2021 | Bioorganic & medicinal chemistry, 03-01, Volume: 33 | Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189. |
| AID1241324 | Inverse agonist activity at CB1 receptor (unknown origin) expressed in HEK cells assessed as increase in cAMP production at 5 x 10'-6 to 5 x 10'-10 M measured at 50 mins by ACTOne dye-based fluorescence assay in presence of forskolin and Ro 20-1724 relati | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist. |
| AID414287 | Binding affinity to human CB2 receptor transfected in HEK293 cells | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Design and synthesis of novel tri-aryl CB2 selective cannabinoid ligands. |
| AID1719530 | Inverse agonist activity at human recombinant cannabinoid CB2 receptor expressed in HEK cells transfected with CNG assessed as increase in cAMP level measured up to 1 hr by ACTOne membrane potential dye based assay | 2021 | Bioorganic & medicinal chemistry, 03-01, Volume: 33 | Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189. |
| AID1241327 | Non-competitive antagonist activity at CB2 receptor (unknown origin) expressed in HEK cells incubated in dark condition for 30 mins prior to CP55940 addition measured at 50 mins by Schild plot analysis | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist. |
| AID1719542 | Inverse agonist activity at cannabinoid CB2 receptor in human U2OS cells assessed as induction of beta-arrestin recruitment using CCF4/AM as substrate preincubated for 5 hrs followed by substrate addition and measured after 2 hrs by Tango assay | 2021 | Bioorganic & medicinal chemistry, 03-01, Volume: 33 | Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189. |
| AID1719541 | Inverse agonist activity at cannabinoid CB1 receptor in human U2OS cells assessed as emission ratio using CCF4/AM as substrate preincubated for 5 hrs followed by substrate addition and measured after 2 hrs by Tango assay | 2021 | Bioorganic & medicinal chemistry, 03-01, Volume: 33 | Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189. |
| AID1241322 | Selectivity ratio of Ki for CB1 receptor (unknown origin) to Ki for CB2 receptor (unknown origin) | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist. |
| AID414286 | Binding affinity to human CB1 receptor transfected in HEK293 cells | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Design and synthesis of novel tri-aryl CB2 selective cannabinoid ligands. |
| AID1719531 | Inverse agonist activity at human recombinant cannabinoid CB2 receptor expressed in HEK cells transfected with CNG assessed as increase in cAMP level measured up to 1 hr by ACTOne membrane potential dye based assay relative to control | 2021 | Bioorganic & medicinal chemistry, 03-01, Volume: 33 | Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189. |
| AID1241321 | Displacement of [3H]-CP55940 from CB2 receptor (unknown origin) expressed in CHO cell membranes after 90 mins by liquid scintillation counting analysis | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist. |
| AID1241320 | Displacement of [3H]-CP55940 from CB1 receptor (unknown origin) expressed in CHO cell membranes after 90 mins by liquid scintillation counting analysis | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist. |
| AID1241323 | Inverse agonist activity at CB1 receptor (unknown origin) expressed in HEK cells assessed as increase in cAMP production measured at 50 mins by ACTOne dye-based fluorescence assay in presence of forskolin and Ro 20-1724 | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist. |
| AID1719529 | Inverse agonist activity at human recombinant cannabinoid CB1 receptor expressed in HEK cells transfected with CNG assessed as increase in cAMP level measured up to 1 hr by ACTOne membrane potential dye based assay relative to control | 2021 | Bioorganic & medicinal chemistry, 03-01, Volume: 33 | Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189. |
| AID1719526 | Displacement of [3H]-CP55940 from human recombinant cannabinoid CB2 receptor expressed in HEK cell membranes incubated for 1.5 hrs by liquid scintillation counting method | 2021 | Bioorganic & medicinal chemistry, 03-01, Volume: 33 | Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189. |
| AID414288 | Selectivity ratio of Ki for human CB1 receptor to Ki for human CB2 receptor | 2009 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
| Design and synthesis of novel tri-aryl CB2 selective cannabinoid ligands. |
| AID1241325 | Inverse agonist activity at CB2 receptor (unknown origin) expressed in HEK cells assessed as increase in cAMP production measured at 50 mins by ACTOne dye-based fluorescence assay in presence of forskolin and Ro 20-1724 | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17
| Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |