Compounds > respirantin
Page last updated: 2024-11-12

respirantin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

respirantin: from Streptomyces sp. No. 4403; cyclodepsipeptide; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

respirantin : A cyclodepsipeptide isolated from Streptomyces and Kitasatospora and has been shown to exhibit antimicrobial and antineoplastic activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID16756914
CHEMBL ID268884
CHEBI ID66299
MeSH IDM0217184

Synonyms (7)

Synonym
chebi:66299 ,
respirantin
CHEMBL268884
cyclodepsipeptide 1
n-[(2s,5s,8s,13s,16r,17s)-5-(butan-2-yl)-2,10,10,16-tetramethyl-8,13-bis(2-methylpropyl)-3,6,9,11,14,18-hexaoxo-1,4,12,15-tetraoxa-7-azacyclooctadecan-17-yl]-3-(formylamino)-2-hydroxybenzamide
Q27134841
n-[(2s,5s,8s,13s,16r,17s)-5-butan-2-yl-2,10,10,16-tetramethyl-8,13-bis(2-methylpropyl)-3,6,9,11,14,18-hexaoxo-1,4,12,15-tetraoxa-7-azacyclooctadec-17-yl]-3-formamido-2-hydroxybenzamide
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
antimicrobial agentA substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
benzamides
cyclodepsipeptideA depsipeptide in which the amino and hydroxy carboxylic acid residues are connected in a ring.
formamidesAmides with the general formula R(1)R(2)NCHO (R(1) and R(2) can be H).
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID292580Growth inhibition of human KM20L2 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 561. Total synthesis of respirantin.
AID292572Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.
AID292573Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.
AID292581Growth inhibition of human DU145 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 561. Total synthesis of respirantin.
AID292577Growth inhibition of human MCF7 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 561. Total synthesis of respirantin.
AID292578Growth inhibition of human SF268 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 561. Total synthesis of respirantin.
AID292570Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.
AID292571Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.
AID292569Growth inhibition of human BXPC3 cells after 48 hrs by sulforhodamine B assay2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.
AID292574Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.
AID292565Antifungal activity against Cryptococcus neoformans ATCC 901122007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.
AID292568Growth inhibition of mouse P388 cells after 48 hrs by sulforhodamine B assay2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.
AID292579Growth inhibition of human NCI-H460 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 561. Total synthesis of respirantin.
AID292575Growth inhibition of mouse P388 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 561. Total synthesis of respirantin.
AID292576Growth inhibition of human BXPC3 cells2007Journal of natural products, Jul, Volume: 70, Issue:7
Antineoplastic agents. 561. Total synthesis of respirantin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's6 (54.55)29.6817
2010's4 (36.36)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.59 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dihydroxyphenylalanine
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.. dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.		2.0310hydroxyphenylalanine;
non-proteinogenic alpha-amino acid;
tyrosine derivative		human metabolite
cx546
1-(1,4-benzodioxan-6-ylcarbonyl)piperidine: structure in first source		2.0310
leucine
Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.		2.110amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
leucinal
leucinal: RN given refers to (S)-isomer		2.110
tetrodotoxin
Tetrodotoxin: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.. tetrodotoxin : A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.		2.0310azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
antimycin a
Antimycin A: An antibiotic substance produced by Streptomyces species. It inhibits mitochondrial respiration and may deplete cellular levels of ATP. Antimycin A1 has been used as a fungicide, insecticide, and miticide. (From Merck Index, 12th ed). antimycin A : A nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison.		2.110amidobenzoic acid
piperidines
Piperidines: A family of hexahydropyridines.		2.0310
neoantimycin
[no description available]		2.110
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0310
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.4920
Francisella tularensis Infection
[description not available]		02.2110
Tularemia
A plague-like disease of rodents, transmissible to man. It is caused by FRANCISELLA TULARENSIS and is characterized by fever, chills, headache, backache, and weakness.		02.2110
Active Hyperemia
[description not available]		02.0810
Experimental Lung Inflammation
Inflammation of any part, segment or lobe, of the lung parenchyma.		02.0810
Hyperemia
The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).		02.0810
Pneumonia
Infection of the lung often accompanied by inflammation.		02.0810
Hyperthyroid
[description not available]		02.0410
Hyperthyroidism
Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.		02.0410
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.0310
Autism-Dementia-Ataxia-Loss of Purposeful Hand Use Syndrome
[description not available]		02.0310
Rett Syndrome
An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)		02.0310