Compounds > propanoldiaminetetracetic acid
Page last updated: 2024-11-05

propanoldiaminetetracetic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID20442
CHEMBL ID3246005
SCHEMBL ID21228
SCHEMBL ID10825921
MeSH IDM0139553

Synonyms (47)

Synonym
glycine, n,n'-(1-methyl-1,2-ethanediyl)bis(n-(carboxymethyl)-
brn 2223855
propane-1,2-dinitrilotetraacetic acid
propylenediamine tetra-acetic acid
ccris 1250
pdta
medta
1,2-propylenediaminetetraacetic acid
1,2-diaminopropanetetraacetic acid
acetic acid, (propylenedinitrilo)tetra-
einecs 224-559-7
propanoldiaminetetracetic acid
1,2-propylenediamine tetraacetic acid
nsc-132341
nsc132341
1,2-diaminopropane-n,n,n',n'-tetraacetic acid, >=98%
D1329
2-[2-[bis(carboxymethyl)amino]propyl-(carboxymethyl)amino]acetic acid
FT-0657928
4408-81-5
propylenediamine-n,n,n',n'-tetraacetic acid
1,2-diaminopropane-n,n,n',n'-tetraacetic acid
methyl-edta
3-04-00-01190 (beilstein handbook reference)
1,2-diaminopropane-n,n,n,n-tetraaceticacid
A826486
FT-0606336
AKOS015893920
CHEMBL3246005
SCHEMBL21228
mfcd00004286
W-106211
1,2-diaminopropane tetraacetic acid
SCHEMBL10825921
1,2-diaminopropane-n,n,n',n'-tetraaceticacid
glycine, n,n'-(1-methyl-1,2-ethanediyl)bis[n-(carboxymethyl)-
2-({1-[bis(carboxymethyl)amino]propan-2-yl}(carboxymethyl)amino)acetic acid
AS-65818
propylenediamine tetraacetic acid
1,2-diaminopropane-n,n,n,n-tetraacetic acid
2,2',2'',2'''-(propane-1,2-diylbis(azanetriyl))tetraacetic acid
AMY16019
D89837
CS-0323146
DTXSID101253702
1,2-diaminopropane-n,n,n inverted exclamation mark ,n inverted exclamation mark -tetraacetic acid
SY050057

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Results are presented for several sets of experiments, including dose-response data for weakly chelated Mn2+ and time-response data for free and complexed Mn2+."( Magnetic field dependence of proton relaxation rates in tissue with added Mn2+: rabbit liver and kidney.
Brown, RD; Burnett, KR; Goldstein, EJ; Koenig, SH; Wolf, GL, 1985)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID1134121Inhibition of scheduled DNA synthesis in chinese hamster V79-4 cells assessed as DNA synthesis at 10'-5 M measured at 10 hrs by [3H]thymidine uptake /autoradiography (Rvb = 81.7 %)1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Study of trans-cyclopropylbis (diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis.
AID1134126Induction of scheduled DNA synthesis in chinese hamster V79-4 cells assessed as DNA synthesis at 10'-4 to 10'-5 M measured at 0 to 5 hrs by [3H]thymidine uptake /autoradiography in presence of 2 x 10'-3 M hydroxyurea1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Study of trans-cyclopropylbis (diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis.
AID1134120Inhibition of scheduled DNA synthesis in chinese hamster V79-4 cells assessed as DNA synthesis at 10'-4 M measured at 10 hrs by [3H]thymidine uptake /autoradiography (Rvb = 81.7 %)1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Study of trans-cyclopropylbis (diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis.
AID1134103Cytotoxicity against chinese hamster V79-4 cells assessed as survival using 5 x 10'5 cells per plate at 10'-4 M after 24 hrs1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Study of trans-cyclopropylbis (diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis.
AID1134127Induction of scheduled DNA synthesis in chinese hamster V79-4 cells assessed as DNA synthesis at 10'-3 M measured at 8 hrs by [3H]thymidine uptake /autoradiography in presence of 2 x 10'-3 M hydroxyurea1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Study of trans-cyclopropylbis (diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis.
AID1134119Inhibition of scheduled DNA synthesis in chinese hamster V79-4 cells assessed as DNA synthesis at 10'-3 M measured at 10 hrs by [3H]thymidine uptake /autoradiography (Rvb = 81.7 %)1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Study of trans-cyclopropylbis (diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis.
AID1134104Cytotoxicity against chinese hamster V79-4 cells assessed as survival using 1 x 10'5 cells per plate at 10'-4 M after 24 hrs1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Study of trans-cyclopropylbis (diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis.
AID1134101Cytotoxicity against chinese hamster V79-4 cells assessed as survival using 5 x 10'5 cells per plate at 10'-3 M after 24 hrs1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Study of trans-cyclopropylbis (diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis.
AID1134106Cytotoxicity against chinese hamster V79-4 cells assessed as survival using 1 x 10'5 cells per plate at 10'-5 M after 24 hrs1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Study of trans-cyclopropylbis (diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis.
AID1134105Cytotoxicity against chinese hamster V79-4 cells assessed as survival using 5 x 10'5 cells per plate at 10'-5 M after 24 hrs1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Study of trans-cyclopropylbis (diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis.
AID1134128Induction of scheduled DNA synthesis in chinese hamster V79-4 cells assessed as DNA synthesis at 10'-3 to 10'-5 M measured at 8 hrs by [3H]thymidine uptake /autoradiography in presence of 2 x 10'-3 M hydroxyurea1977Journal of medicinal chemistry, May, Volume: 20, Issue:5
Study of trans-cyclopropylbis (diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (23.08)18.7374
1990's0 (0.00)18.2507
2000's2 (15.38)29.6817
2010's1 (7.69)24.3611
2020's7 (53.85)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.36 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.36)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bromide
Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)		2.0310halide anion;
monoatomic bromine
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		2.3720halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
pentetic acid
Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.		1.9610pentacarboxylic acidcopper chelator
ethylenediamine
ethylenediamine: RN given refers to parent cpd; edamine is the recommended contraction for the ethylenediamine radical. ethylenediamine : An alkane-alpha,omega-diamine in which the alkane is ethane.		2.0510alkane-alpha,omega-diamineGABA agonist
edetic acid
Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.		3.5480ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
cdta
CDTA: RN given refers to parent cpd; structure		2.0310organooxygen compound
manganese
Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.		2.3720elemental manganese;
manganese group element atom		Escherichia coli metabolite;
micronutrient
yttrium
Yttrium: An element of the rare earth family of metals. It has the atomic symbol Y, atomic number 39, and atomic weight 88.91. In conjunction with other rare earths, yttrium is used as a phosphor in television receivers and is a component of the yttrium-aluminum garnet (YAG) lasers.		2.0510d-block element atom;
rare earth metal atom;
scandium group element atom
methylformamide
N-methylformamide : A member of the class of formamides having a N-methyl substituent.		2.0310formamides
icrf 193
4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione: structure given in first source; RN given refers to cpd without isomeric designation. ICRF-193 : An N-alkylpiperazine that is butane which is substituted by a 3,5-dioxopiperazin-1-yl group at positions 2 and 3. The meso isomer.		1.9510
potassium bromide
potassium bromide : A metal bromide salt with a K(+) counterion.		2.0310potassium salt
ticagrelor
Ticagrelor: An adenosine triphosphate analogue and reversible P2Y12 PURINORECEPTOR antagonist that inhibits ADP-mediated PLATELET AGGREGATION. It is used for the prevention of THROMBOEMBOLISM by patients with ACUTE CORONARY SYNDROME or a history of MYOCARDIAL INFARCTION.. ticagrelor : A triazolopyrimidine that is an adenosine isostere; the cyclopentane ring is similar to ribose and the nitrogen-rich [1,2,3]triazolo[4,5-d]pyrimidine moiety resembles the nucleobase adenine. A platelet aggregation inhibitor which is used for prevention of thromboembolic events in patients with acute coronary syndrome.		2.610aryl sulfide;
hydroxyether;
organofluorine compound;
secondary amino compound;
triazolopyrimidines		P2Y12 receptor antagonist;
platelet aggregation inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.8220
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.8220
Cadaver
A dead body, usually a human body.		02.610
Orphan Diseases
Rare diseases that have not been well studied.		02.610
Cystic Fibrosis of Pancreas
[description not available]		02.610
Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.		02.610
Dysplastic Nevus Syndrome, Hereditary
[description not available]		02.610
Chronic Illness
[description not available]		02.3110
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).		02.3110
Electrolytes
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)		02.0310
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0310