Page last updated: 2024-11-12
ponkoranol
Description
ponkoranol: isolated from the plant Salacia reticulata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|
| Salacia | genus | A plant genus of the family Celastraceae. Members contain friedelane-type TRITERPENES and SESQUITERPENES, EUDESMANE.[MeSH] | Celastraceae | A plant family of the order Celastrales, subclass Rosidae, class Magnoliopsida.[MeSH] |
Cross-References
Synonyms (4)
| Synonym |
|---|
| CHEMBL1258528 , |
| bdbm50327501 |
| ponkoranol |
| [(2s,3s,4r,5s)-1-[(2r,3s,4s)-3,4-dihydroxy-2-(hydroxymethyl)thiolan-1-ium-1-yl]-2,4,5,6-tetrahydroxyhexan-3-yl] sulfate |
Research Excerpts
Overview
Ponkoranol is a naturally occurring glucosidase inhibitor isolated from the plant Salacia reticulata.
Protein Targets (3)
Inhibition Measurements
Biological Processes (3)
Molecular Functions (7)
Ceullar Components (5)
Bioassays (6)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID593351 | Inhibition of rat small intestinal maltase after 30 mins | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor. |
| AID593349 | Inhibition of rat small intestinal sucrase after 30 mins | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor. |
| AID578321 | Inhibition of rat intestinal isomaltase | 2011 | Bioorganic & medicinal chemistry, Mar-15, Volume: 19, Issue:6
| Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors. |
| AID578319 | Inhibition of rat intestinal maltase | 2011 | Bioorganic & medicinal chemistry, Mar-15, Volume: 19, Issue:6
| Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors. |
| AID578320 | Inhibition of rat intestinal sucrase | 2011 | Bioorganic & medicinal chemistry, Mar-15, Volume: 19, Issue:6
| Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors. |
| AID516767 | Inhibition of human recombinant N-terminal domain of maltase-glucoamylase after 60 mins by glucose oxidase assay | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
| Probing the active-site requirements of human intestinal N-terminal maltase glucoamylase: the effect of replacing the sulfate moiety by a methyl ether in ponkoranol, a naturally occurring α-glucosidase inhibitor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |