Page last updated: 2024-11-05

poldine methylsulfate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Poldine methylsulfate is a synthetic quaternary ammonium compound that acts as an anticholinergic agent. Its synthesis involves the reaction of poldine with methylsulfate. Poldine methylsulfate exhibits a wide range of pharmacological effects, including inhibition of acetylcholine activity at muscarinic receptors, leading to bronchodilation, reduced gastric secretions, and decreased motility of the gastrointestinal tract. It is primarily used in the treatment of gastrointestinal disorders like peptic ulcer disease and irritable bowel syndrome, as well as for controlling symptoms associated with Parkinson's disease. The research on poldine methylsulfate primarily focuses on its therapeutic potential in various conditions, including its efficacy, safety profile, and interactions with other drugs. The compound is also studied for its potential use in ophthalmology to treat conditions like mydriasis and cycloplegia. Its effects on the autonomic nervous system and its ability to modulate cholinergic signaling pathways make it a subject of ongoing research.'

Cross-References

ID SourceID
PubMed CID11017
CHEMBL ID2106739
SCHEMBL ID250977
MeSH IDM0096976

Synonyms (47)

Synonym
metilsulfate de poldine
poldine methylsulphate
poldine metilsulfate [inn]
i.s. 499
nacton
pyrrolidinium 2-(((hydroxydiphenylacetyl)oxy)methyl)-1,1-dimethyl-, methyl sulfate
564c0w9848 ,
metilsulfato de poldina
2-(hydroxymethyl)-1,1-dimethylpyrrolidinium methyl sulfate benzilate
poldini metilsulfas
metilsulfato de poldina [inn-spanish]
poldine methylsulfate [usan:usp]
unii-564c0w9848
poldoni methylsulfas
metilsulfate de poldine [inn-french]
mcn-r-726-47
poldini metilsulfas [inn-latin]
einecs 208-894-6
D05535
545-80-2
poldine metilsulfate
poldine methylsulfate (usan)
poldine methylsulfate
is-499
CHEMBL2106739
poldine methyl methosulfate
i.s.-499
nactate
clb-499
alfaland
poldine metilsulphate
poldine methosulfate
pyrrolidinium, 2-(((hydroxydiphenylacetyl)oxy)methyl)-1,1-dimethyl-, methyl sulfate (salt)
pyrrolidinium, 2-(((2-hydroxy-2,2-diphenylacetyl)oxy)methyl)-1,1-dimethyl-, methyl sulfate (1:1)
poldine metilsulfate [mart.]
pyrrolidinium, 2-(hydroxymethyl)-1,1-dimethyl-, methyl sulfate, benzilate
2-(hydroxymethyl)-1,1-dimethylpyrrolidinium methyl sulphate benzilate
(1-methyl-2-pyrrolidinyl)methyl benzilate methyl methosulfate
poldine metilsulfate [who-dd]
poldine methylsulfate [usan]
poldine methylsulfate [mi]
SCHEMBL250977
poldinmetilsulfat
2-({[hydroxy(diphenyl)acetyl]oxy}methyl)-1,1-dimethylpyrrolidin-1-ium methyl sulfate
DTXSID80969686
Q27261372
(1,1-dimethylpyrrolidin-1-ium-2-yl)methyl 2-hydroxy-2,2-diphenylacetate;methyl sulfate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19909 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.78 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]