| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2. | 2.03 | 1 | 0 | butan-4-olide | metabolite;
neurotoxin |
thiazolidines
Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES. | 2.03 | 1 | 0 | thiazolidine | |
alkenes
[no description available] | 4.51 | 7 | 0 | | |
latrunculin a
latrunculin A: 16-membered macrolide attached to 2-thiazolidinone moiety; from Red Sea sponge Latrunculia magnifica; see also latrunculin B; structure given in first source. latrunculin A : A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes. | 2.03 | 1 | 0 | cyclic hemiketal;
macrolide;
oxabicycloalkane;
thiazolidinone | actin polymerisation inhibitor;
metabolite;
toxin |
sch 642305
Sch 642305: a bicyclic 10-membered macrolide; bacterial DNA primase inhibitor produced by Penicillium verrucosum; structure in first source. sch 642305 : A macrocyclic lactone isolated from the fermentation broth of the fungal culture Penicillium verrucosum and has been shown to exhibit inhibitory activity against bacterial DNA primase enzyme. | 3.16 | 1 | 0 | enone;
macrocyclic lactone | EC 2.7.7.6 (RNA polymerase) inhibitor;
Penicillium metabolite |
stagonolide
stagonolide: nonenolide produced by Stagonospora cirsii (fungi, Ascomycota), a potential mycoherbicide of Cirsium arvense (Asteraceae); structure in first source | 2.04 | 1 | 0 | | |
aspergillide b
aspergillide B: cytotoxic 14-membered macrolide from marine-derived fungus Aspergillus ostianus strain 01F313; structure in first source. aspergillide B : A macrolide that is 4,15-dioxabicyclo[9.3.1]pentadec-9-en-3-one substituted by a hydroxy group at position 14 and a methyl group at position 5 (the 1S,5S,9E,11R,14S stereoisomer). It is isolated from the marine-derived fungus Aspergillus ostianus and exhibits cytotoxic activity against mouse lymphocytic leukemia cells (L1210). | 3.16 | 1 | 0 | bridged compound;
cyclic ether;
macrolide;
secondary alcohol | antineoplastic agent;
Aspergillus metabolite |
aspergillide a
aspergillide A: cytotoxic 14-membered macrolide from marine-derived fungus Aspergillus ostianus strain 01F313; structure in first source. aspergillide A : A macrolide that is 4,15-dioxabicyclo[9.3.1]pentadec-9-en-3-one substituted by a hydroxy group at position 14 and a methyl group at position 5 (the 1R,5S,9E,11R,14S stereoisomer). It is isolated from the marine-derived fungus Aspergillus ostianus and exhibits cytotoxic activity against mouse lymphocytic leukemia cells (L1210). | 3.16 | 1 | 0 | bridged compound;
cyclic ether;
macrolide;
secondary alcohol | antineoplastic agent;
Aspergillus metabolite |