phomoxanthone A: xanthone dimer from the endophytic fungus Phomopsis species; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
phomoxanthone A : A member of the class of xanthones that is a dimer isolated from Phomopsis. It exhibits cytotoxic, antimalarial and antitubercular activities. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 10033008 |
| CHEMBL ID | 504079 |
| CHEBI ID | 66749 |
| MeSH ID | M0400904 |
| Synonym |
|---|
| chebi:66749 , |
| CHEMBL504079 |
| phomoxanthone a |
| (5r*,5'r*,6r*,6'r*,10ar*,10a'r*)-10a,10a'-bis[(acetyloxy)methyl]-1,1',8,8'-tetrahydroxy-6,6'-dimethyl-9,9'-dioxo-5,5',7,7',9,9',10a,10a'-octahydro-6h,6'h-4,4'-bixanthene-5,5'-diyl diacetate |
| rel-[(5r,5'r,6r,6'r,10ar,10a'r)-5,5'-diacetoxy-1,1',8,8'-tetrahydroxy-6,6'-dimethyl-9,9'-dioxo-5,5',6,6',7,7',9,9'-octahydro-10ah,10a'h-4,4'-bixanthene-10a,10a'-diyl]bis(methylene) diacetate |
| 359844-69-2 |
| Q27135373 |
| [(3r,4r,4ar)-5-[(5r,6r,10ar)-5-acetyloxy-10a-(acetyloxymethyl)-1,9-dihydroxy-6-methyl-8-oxo-6,7-dihydro-5h-xanthen-4-yl]-4-acetyloxy-8,9-dihydroxy-3-methyl-1-oxo-3,4-dihydro-2h-xanthen-4a-yl]methyl acetate |
| DTXSID401098707 |
Phomoxanthone A (PhoA) is a compound isolated from the endophytic fungus Phomopsis longicolla, associated with marine algae Bostrychia radicans.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Phomoxanthone A is a naturally occurring molecule and a powerful anti-cancer agent, although its mechanism of action is unknown. " | ( Phomoxanthone A Targets ATP Synthase. Ali, R; Coburn, JM; Mattson, AE; Mistretta, KS; Mitroka-Batsford, S; Parelkar, SS; Scarlata, SF; Thompson, PR; Yerramilli, S, 2022) | 3.61 |
| "Phomoxanthone A (PhoA) is a compound isolated from the endophytic fungus Phomopsis longicolla, associated with marine algae Bostrychia radicans. " | ( Differential genotoxicity and cytotoxicity of phomoxanthone A isolated from the fungus Phomopsis longicolla in HL60 cells and peripheral blood lymphocytes. Almeida, MR; Antunes, LM; de Oliveira, AL; Debonsi, HM; Hernandes, LC; Pavão, GB; Venâncio, VP, 2016) | 2.14 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1600940 | Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential at 5 to 10 uM incubated for 2 hrs by hoechst 33342 staining based fluorescence microscopy | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600907 | Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600886 | Cell cycle arrest in human A2780cisR cells assessed as accumulation at G1 phase at 1 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 68.7%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600853 | Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600887 | Cell cycle arrest in human A2780cisR cells assessed as accumulation at G1 phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 68.7%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600902 | Induction of apoptosis in human A2780cisR cells assessed as accumulation in subG1 phase at 1 uM incubated for 24 hrs by propidium iodide staining based flow cytometry relative to control | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600892 | Cell cycle arrest in human J82 cells assessed as accumulation at G1 phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 69.6%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600872 | Potency index, ratio of cisplatin IC50 to compound IC50 for antiproliferative activity in cisplatin resistant human J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600927 | Induction of apoptosis in human A2780 cells assessed as decrease in cIAP expression at 5 uM incubated for 24 hrs by proteome profiler analysis | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600956 | Ratio of IC50 for induction of mitochondrial membrane depolarization in cisplatin resistant human J82 cells to IC50 for induction of mitochondrial membrane depolarization in human A2780cisR cells after 2 hrs by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600880 | Ratio of IC50 for antiproliferative activity in human A2780cisR cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay to IC50 for antiproliferative activity in human A2780cisR cells assessed as reduction in cell viability incubat | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600882 | Cell cycle arrest in human A2780 cells assessed as accumulation at G1 phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 61.8%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID357313 | Cytotoxicity against human KB cells by SRB assay | 2001 | Journal of natural products, Aug, Volume: 64, Issue:8 | Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species. |
| AID1600911 | Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600857 | Antiproliferative activity against human Cal27CisR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600877 | Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600948 | Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential at 1 uM by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600895 | Cell cycle arrest in cisplatin resistant human J82 cells assessed as accumulation at G1 phase at 1 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 78.1%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600910 | Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600931 | Induction of apoptosis in human A2780cisR cells assessed as decrease in claspin expression at 5 uM incubated for 24 hrs by proteome profiler analysis | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600874 | Potency index, ratio of cisplatin IC50 to compound IC50 for antiproliferative activity in human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600952 | Induction of apoptosis in human A2780cisR cells assessed as decrease in mitochondrial membrane potential at 1 uM incubated for 24 hrs by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600943 | Induction of apoptosis in human A2780 cells assessed as nuclear condensation by measuring reduced size and increased intensity of nuclei at 10 uM incubated for 24 hrs by hoechst 33342 staining based fluorescence microscopy | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600916 | Induction of apoptosis in human J82 cells assessed as mitochondrial membrane potential at 1 uM incubated for 2 hrs by hoechst 33342 staining based fluorescence microscopy | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600899 | Induction of apoptosis in human A2780 cells assessed as accumulation in subG1 phase incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 10%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600883 | Cell cycle arrest in human A2780 cells assessed as accumulation at G1 phase at 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 61.8%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600905 | Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600897 | Cell cycle arrest in cisplatin resistant human J82 cells assessed as accumulation at G1 phase at 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 78.1%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600878 | Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600852 | Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600908 | Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600855 | Antiproliferative activity against cisplatin-resistant human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600906 | Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600858 | Antiproliferative activity against human KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID357314 | Cytotoxicity against human BC1 cells by SRB assay | 2001 | Journal of natural products, Aug, Volume: 64, Issue:8 | Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species. |
| AID1600891 | Cell cycle arrest in human J82 cells assessed as accumulation at G1 phase at 1 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 69.6%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600865 | Potency index, ratio of cisplatin IC50 to compound IC50 for antiproliferative activity in human A2780cisR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600951 | Induction of apoptosis in human A2780 cells assessed as decrease in mitochondrial membrane potential at 1 uM incubated for 24 hrs by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600856 | Antiproliferative activity against human CAL27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600900 | Induction of apoptosis in human A2780 cells assessed as accumulation in subG1 phase incubated for 24 hrs by propidium iodide staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600912 | Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential at 1 uM incubated for 1 hr by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600926 | Induction of apoptosis in human A2780 cells assessed as increase in caspase 3 cleavage at 5 uM incubated for 24 hrs by proteome profiler analysis | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID357315 | Cytotoxicity against african green monkey Vero cells by SRB assay | 2001 | Journal of natural products, Aug, Volume: 64, Issue:8 | Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species. |
| AID1600901 | Induction of apoptosis in human A2780 cells assessed as accumulation in subG1 phase at 1 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 10%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600893 | Cell cycle arrest in human J82 cells assessed as accumulation at G1 phase at 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 69.6%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600864 | Potency index, ratio of cisplatin IC50 to compound IC50 for antiproliferative activity in human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600868 | Potency index, ratio of cisplatin IC50 to compound IC50 for antiproliferative activity in human CAL27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600955 | Ratio of IC50 for induction of mitochondrial membrane depolarization in human J82 cells to IC50 for induction of mitochondrial membrane depolarization human A2780 cells after 2 hrs by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600859 | Antiproliferative activity against human cisplatin resistant KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600929 | Induction of apoptosis in human A2780cisR cells assessed as increase in caspase 3 cleavage at 5 uM incubated for 24 hrs by proteome profiler analysis | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID357312 | Antitubercular activity against Mycobacterium tuberculosis H37Ra by microplate Alamar blue assay | 2001 | Journal of natural products, Aug, Volume: 64, Issue:8 | Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species. |
| AID1600875 | Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600876 | Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600947 | Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential at 1 uM by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600896 | Cell cycle arrest in cisplatin resistant human J82 cells assessed as accumulation at G1 phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 78.1%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600938 | Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600903 | Induction of apoptosis in human J82 cells assessed as accumulation in subG1 phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry relative to control | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600890 | Cell cycle arrest in human A2780cisR cells assessed as accumulation at G1 phase incubated for 24 hrs by propidium iodide staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600925 | Induction of apoptosis in human J82 cells assessed as increase in activation of caspase 3/7 at 50 uM incubated for 24 hrs by hoechst 33342 staining based fluorescence microscopy (Rvb = 1.1%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600934 | Effect on ROS generation in human A2780 cells at 316 nM incubated for 18 hrs by H2DCFDA staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID357311 | Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake | 2001 | Journal of natural products, Aug, Volume: 64, Issue:8 | Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species. |
| AID1600950 | Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential after 24 hrs by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600860 | Antiproliferative activity against human J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600919 | Induction of apoptosis in human A2780 cells assessed as increase in intracellular calcium level at 1 and 30 uM incubated for 30 mins by fluorimetry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600888 | Cell cycle arrest in human A2780cisR cells assessed as accumulation at G1 phase at 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 68.7%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600942 | Induction of apoptosis in human A2780cisR cells assessed as nuclear condensation by measuring reduced size and increased intensity of nuclei at 10 uM incubated for 24 hrs by hoechst 33342 staining based fluorescence microscopy | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600946 | Ratio of IC50 for antiproliferative activity in human J82 cells to cisplatin-resistant human J82 cells assessed as reduction of cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600918 | Induction of apoptosis in human A2780 cells assessed as increase in intracellular calcium level at 10 to 30 uM incubated for 30 mins in presence of 1 mM extracellular calcium by fluorimetry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600867 | Potency index, ratio of cisplatin IC50 to compound IC50 for antiproliferative activity in cisplatin-resistant human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600941 | Induction of apoptosis in human J82 cells assessed as nuclear condensation by measuring reduced size and increased intensity of nuclei at 50 uM incubated for 24 hrs by hoechst 33342 staining based fluorescence microscopy | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600871 | Potency index, ratio of cisplatin IC50 to compound IC50 for antiproliferative activity in cisplatin resistant human KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600957 | Induction of apoptosis in cisplatin-resistant human J82 cells assessed as nuclear condensation by measuring reduced size and increased intensity of nuclei at 30 uM incubated for 24 hrs by hoechst 33342 staining based fluorescence microscopy | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600937 | Reduction of H2O2-induced ROS generation in human A2780cisR cells at 316 nM incubated for 18 hrs by H2DCFDA staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600873 | Potency index, ratio of cisplatin IC50 to compound IC50 for antiproliferative activity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600869 | Potency index, ratio of cisplatin IC50 to compound IC50 for antiproliferative activity in human Cal27CisR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600915 | Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential at 1 uM incubated for 2 hrs by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600935 | Effect on ROS generation in human A2780cisR cells at 316 nM incubated for 18 hrs by H2DCFDA staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600932 | Induction of apoptosis in human A2780 cells assessed as plasma membrane damage at 1 to 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600909 | Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600881 | Cell cycle arrest in human A2780 cells assessed as accumulation at G1 phase at 1 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 61.8%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600885 | Cell cycle arrest in human A2780 cells assessed as accumulation at G1 phase incubated for 24 hrs by propidium iodide staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600920 | Induction of apoptosis in human A2780cisR cells assessed as increase in intracellular calcium level at 10 to 30 uM incubated for 30 mins in presence of 1 mM extracellular calcium by fluorimetry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600879 | Ratio of IC50 for antiproliferative activity in human A2780 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay to IC50 for antiproliferative activity in human A2780 cells assessed as reduction in cell viability incubated for 7 | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600863 | Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600914 | Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential at 1 uM incubated for 2 hrs by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600904 | Induction of apoptosis in cisplatin resistant human J82 cells assessed as accumulation in subG1 phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry relative to control | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600870 | Potency index, ratio of cisplatin IC50 to compound IC50 for antiproliferative activity in human KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600930 | Induction of apoptosis in human A2780cisR cells assessed as decrease in cIAP expression at 5 uM incubated for 24 hrs by proteome profiler analysis | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600939 | Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential at 5 to 10 uM incubated for 2 hrs by hoechst 33342 staining based fluorescence microscopy | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600866 | Potency index, ratio of cisplatin IC50 to compound IC50 for antiproliferative activity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600917 | Induction of apoptosis in cisplatin resistant human J82 cells assessed as mitochondrial membrane potential at 1 uM incubated for 2 hrs by hoechst 33342 staining based fluorescence microscopy | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600923 | Induction of apoptosis in human A2780cisR cells assessed as increase in activation of caspase 3/7 at 10 uM incubated for 24 hrs by hoechst 33342 staining based fluorescence microscopy (Rvb = 0.8%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600921 | Induction of apoptosis in human A2780cisR cells assessed as increase in intracellular calcium level at 1 to 30 uM incubated for 30 mins by fluorimetry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600854 | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600928 | Induction of apoptosis in human A2780 cells assessed as decrease in claspin expression at 5 uM incubated for 24 hrs by proteome profiler analysis | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600924 | Induction of apoptosis in cisplatin resistant human J82 cells assessed as increase in activation of caspase 3/7 at 30 uM incubated for 24 hrs by hoechst 33342 staining based fluorescence microscopy (Rvb = 0.5%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600936 | Reduction of H2O2-induced ROS generation in human A2780 cells at 316 nM incubated for 18 hrs by H2DCFDA staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600861 | Antiproliferative activity against human cisplatin resistant J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600933 | Induction of apoptosis in human A2780cisR cells assessed as plasma membrane damage at 1 to 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600922 | Induction of apoptosis in human A2780 cells assessed as increase in activation of caspase 3/7 at 10 uM incubated for 24 hrs by hoechst 33342 staining based fluorescence microscopy (Rvb = 1.4%) | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600913 | Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential at 1 uM incubated for 1 hr by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600949 | Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential afer 24 hrs by TMRE staining based flow cytometry | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| AID1600862 | Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 10-01, Volume: 27, Issue:19 | The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.71) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (9.09%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (90.91%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||