methaniazide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

methaniazide: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	3769
CHEMBL ID	2105190
CHEBI ID	134943
SCHEMBL ID	606355
MeSH ID	M0170242

Synonyms (28)

Synonym
CHEBI:134943
13447-95-5
methaniazide (inn)
D08198
methaniazide
[2-(pyridine-4-carbonyl)hydrazinyl]methanesulfonic acid
isoniazid methanesulfonate
metaniazide
unii-gn8s7zes0f
methaniazide [inn]
methaniazidum [inn-latin]
metaniazide [dcit]
methaniazidum
isonicotinic acid 2-(sulfomethyl)hydrazine
gn8s7zes0f ,
metaniazida [inn-spanish]
metaniazida
einecs 236-605-3
isoniazide sodium methanesulfonate
CHEMBL2105190
methaniazide [who-dd]
4-pyridinecarboxylic acid 2-(sulfomethyl)hydrazide
isoniazid methanesulfonate [mi]
methaniazide [mart.]
SCHEMBL606355
DTXSID2048248
Q27279190
[(pyridin-4-yl)formohydrazido]methanesulfonic acid

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

Class	Description
pyridinemonocarboxylic acid	A monocarboxylic acid in which the carboxy group is attached to a pyridine (or substituted pyridine) ring.
aromatic carboxylic acid	Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
USP1 protein, partial	Homo sapiens (human)	Potency	79.4328	0.0316	37.5844	354.8130	AID504865
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID504749	qHTS profiling for inhibitors of Plasmodium falciparum proliferation	2011	Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043	Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (66.67)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (11.11)	29.6817
2010's	2 (22.22)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 15.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	15.65 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	4.59 (4.65)
Search Engine Demand Index	10.37 (26.88)
Search Engine Supply Index	3.00 (0.95)

This Compound (15.65)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	2 (20.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
niacin Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.	2.62	3	pyridine alkaloid; pyridinemonocarboxylic acid; vitamin B3	antidote; antilipemic drug; EC 3.5.1.19 (nicotinamidase) inhibitor; Escherichia coli metabolite; human urinary metabolite; metabolite; mouse metabolite; plant metabolite; vasodilator agent
isoniazid Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).	3.46	8	carbohydrazide	antitubercular agent; drug allergen
sulfanilamide [no description available]	1.93	1	substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial agent; drug allergen; EC 4.2.1.1 (carbonic anhydrase) inhibitor

Condition	Relationship Strength	Studies
Diffuse Parenchymal Lung Disease [description not available]	2.01	1
Pulmonary Consumption [description not available]	3.04	5
Tuberculosis, Pulmonary MYCOBACTERIUM infections of the lung.	3.04	5
Lung Diseases, Interstitial A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.	2.01	1
Koch's Disease [description not available]	2.85	4
Tuberculosis Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.	2.85	4
Angioneurotic Edema [description not available]	1.97	1
Allergy, Drug [description not available]	1.97	1
Myoclonic Jerk [description not available]	1.97	1
Pleurisy, Tuberculous [description not available]	1.97	1
Angioedema Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.	1.97	1
Drug Hypersensitivity Immunologically mediated adverse reactions to medicinal substances used legally or illegally.	1.97	1

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