Compounds > isoegomaketone
Page last updated: 2024-12-11

isoegomaketone

Description

isoegomaketone: has antineoplastic activity; isolated from Perilla frutescens [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
PerillagenusA plant genus of the family LAMIACEAE that is a source of perilla alcohol and the oil is rich in alpha-linolenic acid (alpha-18:3).[MeSH]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]
Perilla frutescensspeciesA plant genus of the family LAMIACEAE that is an ingredient of Banxia Houpu (DRUGS, CHINESE HERBAL).[MeSH]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID SourceID
PubMed CID5318556
CHEMBL ID3357563
CHEBI ID180404
SCHEMBL ID11539531
MeSH IDM0568508

Synonyms (24)

Synonym
34348-59-9
(e)-1-(uran-3-yl)-4-methylpent-2-en-1-one
CHEBI:180404
2-penten-1-one, 1-(3-furanyl)-4-methyl-
isoegomaketone
(e)-1-(furan-3-yl)-4-methylpent-2-en-1-one
AKOS006279583
SCHEMBL11539531
3253-49-4
XEYCZVQIOJGCNL-ONEGZZNKSA-N
(2e)-1-(furan-3-yl)-4-methylpent-2-en-1-one
CHEMBL3357563
1-(3-furanyl)-4-methyl-2-penten-1-one, 9ci
1-(3-furanyl)-4-methyl-2-penten-1-one
2-penten-1-one, 1-(3-furanyl)-4-methyl-, (2e)-
AMY19639
DTXSID701266498
(2e)-1-(3-furanyl)-4-methyl-2-penten-1-one
EN300-6488985
N8LS3K868H
1-furan-3-yl-4-methylpent-2-en-1-one
1-(3-furyl)-4-methyl-trans-2-penten-1-one
1-(furan-3-yl)-4-methyl-pent-2-en-1-one
2-penten-1-one, 1-(3-furyl)-4-methyl-, (e)-

Research Excerpts

Overview

Isoegomaketone (IK) is a major biologically active component of Perilla frutescens. The mechanism by which IK induces apoptosis has never been studied.

ExcerptReferenceRelevance
"Isoegomaketone (IK) is a known component of "( 9‑Hydroxy‑isoegomaketone inhibits LPS‑induced NO and inflammatory cytokine production in RAW264.7 cells.
Han, AR; Jeong, HG; Jin, CH; Kim, HM; Nam, B; Nam, JW; Paudel, SB, 2021)		2.47
"Isoegomaketone (IK) is a major biologically active component of Perilla frutescens. "( Isoegomaketone induces apoptosis in SK-MEL-2 human melanoma cells through mitochondrial apoptotic pathway via activating the PI3K/Akt pathway.
Jeong, IY; Kwon, SJ; Lee, JH; Lee, MK; Moon, KD; Seo, KI; Yee, ST, 2014)		3.29
"Isoegomaketone (IK) is an essential oil component of Perilla frutescens (L.), but the mechanism by which IK induces apoptosis has never been studied. "( Isoegomaketone induces apoptosis through caspase-dependent and caspase-independent pathways in human DLD1 cells.
Byun, MW; Cho, BO; Jeong, IY; Jin, CH; Park, YD; Ryu, HW; Seo, KI, 2011)		3.25
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
aromatic ketoneA ketone in which the carbonyl group is attached to an aromatic ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (78)

Assay IDTitleYearJournalArticle
AID1169586Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as p53 expression at 20 uM after 6 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169561Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR5 expression at 20 uM after 3 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169577Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as p53 expression at 10 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169556Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR4 expression at 20 uM after 3 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169554Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR5 expression at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169529Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as procaspase-3 activation at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169582Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as CHOP expression at 10 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169553Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR5 expression at 10 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169565Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as accumulation at Sub-G1 phase at 20 uM after 24 hrs by annexin-V/propidium iodide staining-based flow cytometry in presence of Dr5 Fc chimera (Rvb = 4.8%)2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169591Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as CHOP expression at 20 uM after 12 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169532Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as procaspase-8 activation at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169578Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as p53 expression at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169524Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as accumulation at Sub-G1 phase at 20 uM after 24 hrs by annexin-V/propidium iodide staining-based flow cytometry (Rvb = 4.8%)2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169544Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as cytochrome C level in mitochondria at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169540Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as AIF level in mitochondria at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169569Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as PARP cleavage at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169589Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as CHOP expression at 20 uM after 3 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169557Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR4 expression at 20 uM after 6 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169550Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR4 expression at 40 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169560Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR4 expression at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169530Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as Bax activation at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169588Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as p53 expression at 20 uM after 18 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169595Induction of ROS generation in human RC-58T/h/SA#4 cells at 20 uM after 30 mins by flow cytometry (Rvb = 1.9%)2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169573Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as CHOP expression after 3 to 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169555Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR5 expression at 40 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169587Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as p53 expression at 20 uM after 12 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169522Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells at 20 uM after 24 hrs by annexin-V/propidium iodide staining-based flow cytometry relative to control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169572Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as p53 expression at 2.5 to 40 uM by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169549Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR4 expression at 10 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169574Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as CHOP expression at 2.5 to 40 uM by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169593Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as ROS generation at 20 uM after 24 hrs by SRB assay in presence of NAC2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169581Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as CHOP expression at 5 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169580Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as CHOP expression at 2.5 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169576Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as p53 expression at 5 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169579Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as p53 expression at 40 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169583Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as CHOP expression at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169534Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as procaspase-3 activation at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169531Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as Bcl-2 activation at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169546Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR5 expression at 20 uM by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169564Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR5 expression at 20 uM after 18 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169571Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as p53 expression after 3 to 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169542Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as cytochrome C level in mitochondria at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169552Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR5 expression at 5 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169559Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR4 expression at 20 uM after 18 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169567Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as procaspase-9 activation at 20 uM after 24 hrs by immunoblotting analysis in presence of Dr5 Fc chimera relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169590Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as CHOP expression at 20 uM after 6 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169568Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as procaspase-3 activation at 20 uM after 24 hrs by immunoblotting analysis in presence of Dr5 Fc chimera relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169548Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR4 expression at 5 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169558Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR4 expression at 20 uM after 12 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169526Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as accumulation at Sub-G1 phase at 20 uM after 24 hrs by annexin-V/propidium iodide staining-based flow cytometry in presence of pan-caspase inhibitor z-VAD-fmk (Rvb = 4.8%)2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169521Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as condensation of chromatin at 20 uM after 24 hrs by Hoechst 33258 staining-based fluorescence microscopy2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169585Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as p53 expression at 20 uM after 3 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169594Induction of ROS generation in human RC-58T/h/SA#4 cells at 10 uM after 30 mins by flow cytometry (Rvb = 1.9%)2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169538Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as AIF level in mitochondria at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169541Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as cytochrome C level in cytosol at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169537Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as AIF level in cytosol at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169527Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as procaspase-8 activation at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169528Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as procaspase-9 activation at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169551Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR5 expression at 2.5 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169575Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as p53 expression at 2.5 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169520Sensitization of TRAIL-induced cytotoxicity against human RWPE1 cells assessed as cell viability at 20 uM after 24 hrs by SRB assay2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169519Sensitization of TRAIL-induced cytotoxicity against human RC-58T/h/SA#4 cells assessed as cell viability at 5 to 20 uM after 24 hrs by SRB assay2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169533Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as procaspase-9 activation at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169547Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR4 expression at 2.5 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169584Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as CHOP expression at 40 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169545Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR5 expression after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169563Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR5 expression at 20 uM after 12 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169539Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as AIF level in cytosol at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169596Induction of ROS generation in human RC-58T/h/SA#4 cells at 40 uM after 30 mins by flow cytometry (Rvb = 1.9%)2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169536Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as Bcl-2 activation at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169570Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as PARP cleavage at 20 uM after 24 hrs by immunoblotting analysis in presence of Dr5 Fc chimera relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169535Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as Bax activation at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169543Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as cytochrome C level in cytosol at 20 uM after 24 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169562Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as DR5 expression at 20 uM after 6 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169592Induction of apoptosis in human RC-58T/h/SA#4 cells assessed as CHOP expression at 20 uM after 18 hrs by immunoblotting analysis relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169525Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as accumulation at Sub-G1 phase at 20 uM after 24 hrs by annexin-V/propidium iodide staining-based flow cytometry (Rvb = 4.8%)2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169523Induction of apoptosis in human RC-58T/h/SA#4 cells at 20 uM after 24 hrs by annexin-V/propidium iodide staining-based flow cytometry relative to control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
AID1169566Sensitization of TRAIL-induced apoptosis in human RC-58T/h/SA#4 cells assessed as procaspase-8 activation at 20 uM after 24 hrs by immunoblotting analysis in presence of Dr5 Fc chimera relative to untreated control2014Journal of natural products, Nov-26, Volume: 77, Issue:11
Sensitization of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant primary prostate cancer cells by isoegomaketone from Perilla frutescens.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (10.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (70.00)24.3611
2020's2 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.97

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.97 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.37 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.97)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source		2.110chromones;
morpholines;
organochlorine compound		autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector
perillaldehyde
perillaldehyde: from oil of Perillae herba; has neuropharmacological actions; RN given refers to cpd without isomeric designation; structure in Merck Index, 9th ed, #6956. perillyl aldehyde : An aldehyde that is cyclohex-1-ene-1-carbaldehyde substituted by a prop-1-en-2-yl group at position 4.		2.2510aldehyde;
olefinic compound		human metabolite;
mouse metabolite;
volatile oil component
perillene
perillene: structure in first source. perillene : A monoterpenoid that is furan in which the hydrogen at position 3 is replaced by a 4-methylpent-3-en-1-yl group. A defensive allomone of thrips that has a flowery, citrus-like flavour.		2.2510furans;
monoterpenoid		fragrance;
metabolite;
semiochemical
piperitenone
piperitenone: structure given in first source		2.2510p-menthadien-3-one
citral
citral: Xref geranial: geraniol is also available; Xref neral: nerol is also available; vitamin A antagonist; oxygenated monoterpene; inhibits cytosolic dehydrogenases; structure. citral : An enal that consists of octa-2,6-dienal bearing methyl substituents at positions 3 and 7. A mixture of the two geometric isomers geranial and neral, it is the major constituent (75-85%) of oil of lemon grass, the volatile oil of Cymbopogon citratus, or of C. flexuosus. It also occurs in oils of verbena, lemon, and orange.		2.2510enal;
monoterpenoid;
polyprenal		plant metabolite;
volatile oil component
alpha-linolenic acid
linolenic acid : A two-membered subclass of octadecatrienoic acid comprising the (9Z,12Z,15Z)- and (6Z,9Z,12Z)-isomers. Linolenic acids are nutrients essential to the formation of prostaglandins and are also used in making paints and synthetic resins.. linolenate : A polyunsaturated fatty acid anion obtained by deprotonation of the carboxy group of either alpha- or gamma-linolenic acid.		2.2510linolenic acid;
omega-3 fatty acid		micronutrient;
mouse metabolite;
nutraceutical
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.0610
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Prostate
[description not available]		02.110
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.110
Innate Inflammatory Response
[description not available]		02.8330
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.8330
Adjuvant Arthritis
[description not available]		02.1510
Rheumatoid Arthritis
[description not available]		02.1510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1510
Anasarca
[description not available]		02.1510
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.		02.1510
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.1510
Hepatocellular Carcinoma
[description not available]		02.0810
Cancer of Liver
[description not available]		02.0810
Experimental Hepatoma
[description not available]		02.0810
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.0810
Liver Neoplasms
Tumors or cancer of the LIVER.		02.0810
B16 Melanoma
[description not available]		07.110
Malignant Melanoma
[description not available]		02.110
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		07.110
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