isoegomaketone and Liver-Neoplasms

isoegomaketone has been researched along with Liver-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for isoegomaketone and Liver-Neoplasms

Article	Year
Extract of Perilla frutescens inhibits tumor proliferation of HCC via PI3K/AKT signal pathway. African journal of traditional, complementary, and alternative medicines : AJTCAM, 2013, Volume: 10, Issue:2 In this study, isoegomaketone(IK) was isolated from Perilla frutescens(L.), a Chinese herbal. The effects of IK were examined by cell viability assay, colony formation assay, xenograft tumor assay and western blotting in HCC cells. We found that IK inhibited cell viability, and its administration decreased tumor volume and weight profoundly. The presence of IK(10 nmol/l) produced a dramatic decrease of pAkt, while total Akt level was not affected. The data suggested that IK from perilla suppressed HCC tumor growth via blocking PI3K/Akt signaling pathway. Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Furans; Ketones; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Perilla frutescens; Phosphatidylinositol 3-Kinases; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Signal Transduction; Xenograft Model Antitumor Assays	2013

Article

Year

Extract of Perilla frutescens inhibits tumor proliferation of HCC via PI3K/AKT signal pathway.

African journal of traditional, complementary, and alternative medicines : AJTCAM, 2013, Volume: 10, Issue:2

In this study, isoegomaketone(IK) was isolated from Perilla frutescens(L.), a Chinese herbal. The effects of IK were examined by cell viability assay, colony formation assay, xenograft tumor assay and western blotting in HCC cells. We found that IK inhibited cell viability, and its administration decreased tumor volume and weight profoundly. The presence of IK(10 nmol/l) produced a dramatic decrease of pAkt, while total Akt level was not affected. The data suggested that IK from perilla suppressed HCC tumor growth via blocking PI3K/Akt signaling pathway.

Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Furans; Ketones; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Perilla frutescens; Phosphatidylinositol 3-Kinases; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Signal Transduction; Xenograft Model Antitumor Assays

2013