Compounds > handelin
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handelin

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Description

handelin: Chinese drug isolated from flowers of Chrysanthemum indicum L.; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
ChrysanthemumgenusA plant genus of the family ASTERACEAE. The common names of daisy or marguerite are easily confused with other plants. Some species in this genus have been reclassified to TANACETUM.[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]
Chrysanthemum indicumspecies[no description available]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]
Chrysanthemum indicumspecies[no description available]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID90474153
CHEMBL ID3264099
CHEBI ID189103
MeSH IDM0150378

Synonyms (6)

Synonym
handelin
CHEBI:189103
[(1'r,2'r,3r,3ar,4s,5's,6r,6ar,9's,9ar,9br,10's,11'r)-2',6-dihydroxy-2',6,9,11'-tetramethyl-6'-methylidene-2,7'-dioxospiro[4,5,6a,7,9a,9b-hexahydro-3ah-azuleno[4,5-b]uran-3,15'-8-oxatetracyclo[9.2.2.01,10.05,9]pentadec-12-ene]-4-yl] acetate
62687-22-3
CHEMBL3264099
AC-34991

Research Excerpts

Overview

Handelin is a natural ingredient extracted from Chrysanthemum boreale flowers. It has been shown to decrease stress-related cell death, prolong lifespan, and promote anti-photoaging.

ExcerptReferenceRelevance
"Handelin is a natural ingredient extracted from Chrysanthemum boreale flowers that has been shown to decrease stress-related cell death, prolong lifespan, and promote anti-photoaging. "( Handelin protects human skin keratinocytes against ultraviolet B-induced photodamage via autophagy activation by regulating the AMPK-mTOR signaling pathway.
Chu, J; Duan, J; He, M; Lin, X; Ma, Q; Sun, S; Wang, Y; Xiang, Y, 2023)		3.8
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
sesterterpenoidAny terpenoid derived from a sesterterpene. The term includes compounds in which the C25 skeleton of the parent sesterterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups). Sometimes sesterterpenoids are erroneously referred to as sesterpenoids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (77)

Assay IDTitleYearJournalArticle
AID1139288Antiinflammatory activity in po dosed rat paw edema model assessed as inhibition of carrageenan-induced serum IL-1beta production administered 30 mins prior to carrageenan challenge measured after 6 hrs by Western blotting analysis relative to vehicle-tre2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139323Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced IL-1beta protein expression at 40 uM after 4 hrs by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139279Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced miR-155 mRNA expression after 8 hrs by RT-PCR analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139326Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced IL-1beta mRNA expression at 40 uM after 4 hrs by RT-PCR analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139313Inhibition of LPS-induced NF-kappaB p50 binding to DNA in mouse RAW264.7 cells at 10 to 40 uM after 1.5 hrs by spectrophotometry in presence of wild type oligonucleotide2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139259Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 20 uM administered 30 mins prior to LPS challenge measured after 20 hrs by Griess assay relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139274Inhibition of LPS-induced NF-kappaB p65 binding to DNA in mouse RAW264.7 cells at 10 to 40 uM after 1.5 hrs by spectrophotometry2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139266Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS mRNA expression at 40 uM after 5 hrs by RT-PCR analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139278Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced IL-1beta mRNA expression at 10 uM after 4 hrs by RT-PCR analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139265Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced COX2 protein expression after 5 hrs by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139269Inhibition of LPS-induced NF-kappaB transcriptional activity in mouse RAW264.7 cells treated 2 hrs prior to LPS challenge measured after 16 hrs by SEAP reporter gene assay relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139301Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced COX2 mRNA expression at 10 uM after 5 hrs by RT-PCR analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139310Inhibition of LPS-induced NFkappaB transcriptional activity in mouse RAW264.7 cells assessed as reduction of IkappaB-alpha level at 10 uM after 30 mins by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139280Inhibition LPS-induced JNK1/2 phosphorylation at Thr183/Tyr15 in mouse RAW264.7 cells at 10 uM administered 30 mins prior to LPS challenge measured after 30 mins by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139299Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced COX2 protein expression at 40 uM after 16 hrs by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139283Antiinflammatory activity in rat paw edema model assessed as inhibition of carrageenan-induced paw edema at 10 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 4 hrs relative to vehicle-treated control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139272Inhibition of LPS-induced NFkappaB transcriptional activity in mouse RAW264.7 cells assessed as reduction of phosphorylated IkappaB-alpha level at 10 uM after 30 mins by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139273Inhibition of LPS-induced NF-kappaB p50 binding to DNA in mouse RAW264.7 cells at 10 to 40 uM after 1.5 hrs by spectrophotometry2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139293Antiinflammatory activity in ICR mouse ear edema model assessed as inhibition of TPA-induced IL-1beta protein expression in ear tissue at 10 to 20 mg/kg, po administered 30 mins prior to TPA challenge measured after 4 hrs by Western blotting analysis rela2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139281Inhibition LPS-induced ERK1/2 phosphorylation at Thr202/Tyr204 in mouse RAW264.7 cells at 10 uM administered 30 mins prior to LPS challenge measured after 30 mins by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139328Inhibition LPS-induced JNK1/2 phosphorylation at Thr183/Tyr15 in mouse RAW264.7 cells at 40 uM administered 30 mins prior to LPS challenge measured after 30 mins by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1537350Cytotoxicity against human CNE2 cells after 48 hrs by MTT assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Monomeric and Dimeric Cytotoxic Guaianolide-Type Sesquiterpenoids from the Aerial Parts of Chrysanthemum indicum.
AID1139271Inhibition of LPS-induced NFkappaB P50 protein nuclear translocation in mouse RAW264.7 cells at 10 uM after 30 mins by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139262Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production administered 1 hr prior to LPS challenge measured after 20 hrs by EIA relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139286Antiinflammatory activity in rat paw edema model assessed as inhibition of carrageenan-induced COX2 protein expression in paw tissue at 20 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 6 hrs by Western blotting analysis rela2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139258Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production administered 30 mins prior to LPS challenge measured after 20 hrs by Griess assay2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139300Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS mRNA expression at 10 uM after 5 hrs by RT-PCR analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139261Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 40 uM administered 30 mins prior to LPS challenge measured after 20 hrs by Griess assay relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139302Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced COX2 mRNA expression at 20 uM after 5 hrs by RT-PCR analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139289Antiinflammatory activity in ICR mouse ear edema model assessed as inhibition of TPA-induced ear edema at 10 mg/kg, po administered 30 mins prior to TPA challenge measured after 4 hrs relative to vehicle-treated control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139312Inhibition of LPS-induced NFkappaB transcriptional activity in mouse RAW264.7 cells assessed as reduction of IkappaB-alpha level at 40 uM after 30 mins by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1537351Cytotoxicity against human HONE1 cells after 48 hrs by MTT assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Monomeric and Dimeric Cytotoxic Guaianolide-Type Sesquiterpenoids from the Aerial Parts of Chrysanthemum indicum.
AID1139282Inhibition LPS-induced p38 kinase phosphorylation in mouse RAW264.7 cells at 10 to 40 uM administered 30 mins prior to LPS challenge measured after 30 mins by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139325Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced IL-1beta mRNA expression at 20 uM after 4 hrs by RT-PCR analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139290Antiinflammatory activity in ICR mouse ear edema model assessed as inhibition of TPA-induced ear edema at 20 mg/kg, po administered 30 mins prior to TPA challenge measured after 4 hrs relative to vehicle-treated control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139298Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced COX2 protein expression at 20 uM after 16 hrs by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139303Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced COX2 mRNA expression at 40 uM after 5 hrs by RT-PCR analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139330Inhibition LPS-induced ERK1/2 phosphorylation at Thr202/Tyr204 in mouse RAW264.7 cells at 40 uM administered 30 mins prior to LPS challenge measured after 30 mins by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139276Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced IL-1beta protein expression after 4 hrs by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139268Cytotoxicity against mouse RAW264.7 cells assessed as cell survival at 20 uM after 4 hrs by MTT assay relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139277Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced TNF-alpha mRNA expression at 10 uM after 4 hrs by RT-PCR analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1537352Cytotoxicity against human SUNE1 cells after 48 hrs by MTT assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Monomeric and Dimeric Cytotoxic Guaianolide-Type Sesquiterpenoids from the Aerial Parts of Chrysanthemum indicum.
AID1139308Inhibition of LPS-induced NFkappaB transcriptional activity in mouse RAW264.7 cells assessed as reduction of phosphorylated IkappaB-alpha level at 20 uM after 30 mins by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139275Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced TNF-alpha protein expression after 4 hrs by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139264Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS protein expression after 16 hrs by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139294Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS protein expression at 10 uM after 16 hrs by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139270Inhibition of LPS-induced NFkappaB P65 protein nuclear translocation in mouse RAW264.7 cells at 10 uM after 30 mins by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139291Antiinflammatory activity in ICR mouse ear edema model assessed as inhibition of TPA-induced iNOS protein expression in ear tissue at 10 to 20 mg/kg, po administered 30 mins prior to TPA challenge measured after 4 hrs by Western blotting analysis relative2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139317Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced TNF-alpha protein expression at 10 uM after 4 hrs by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139304Inhibition of LPS-induced NFkappaB P65 protein nuclear translocation in mouse RAW264.7 cells at 40 uM after 30 mins by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1537349Cytotoxicity against human CNE1 cells after 48 hrs by MTT assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Monomeric and Dimeric Cytotoxic Guaianolide-Type Sesquiterpenoids from the Aerial Parts of Chrysanthemum indicum.
AID1139284Antiinflammatory activity in rat paw edema model assessed as inhibition of carrageenan-induced paw edema at 20 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 4 hrs relative to vehicle-treated control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139322Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced TNF-alpha mRNA expression at 20 uM after 4 hrs by RT-PCR analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139260Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 40 uM after 4 hrs by MTT assay relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139307Inhibition of LPS-induced NFkappaB P65 protein nuclear translocation in mouse RAW264.7 cells at 20 uM after 30 mins by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139267Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS mRNA expression at 20 uM after 5 hrs by RT-PCR analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139321Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced IL-1beta protein expression at 20 uM after 4 hrs by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139320Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced IL-1beta protein expression at 10 uM after 4 hrs by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139309Inhibition of LPS-induced NFkappaB transcriptional activity in mouse RAW264.7 cells assessed as reduction of phosphorylated IkappaB-alpha level at 40 uM after 30 mins by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139314Inhibition of LPS-induced NF-kappaB p50 binding to DNA in mouse RAW264.7 cells at 10 to 40 uM after 1.5 hrs by spectrophotometry in presence of mutant oligonucleotide2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139311Inhibition of LPS-induced NFkappaB transcriptional activity in mouse RAW264.7 cells assessed as reduction of IkappaB-alpha level at 20 uM after 30 mins by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139329Inhibition LPS-induced ERK1/2 phosphorylation at Thr202/Tyr204 in mouse RAW264.7 cells at 20 uM administered 30 mins prior to LPS challenge measured after 30 mins by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139287Antiinflammatory activity in rat paw edema model assessed as inhibition of carrageenan-induced IL-1beta protein expression in paw tissue at 20 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 6 hrs by Western blotting analysis 2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139315Inhibition of LPS-induced NF-kappaB p65 binding to DNA in mouse RAW264.7 cells at 10 to 40 uM after 1.5 hrs by spectrophotometry in presence of wild type oligonucleotide2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1537353Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay2019Journal of natural products, 02-22, Volume: 82, Issue:2
Monomeric and Dimeric Cytotoxic Guaianolide-Type Sesquiterpenoids from the Aerial Parts of Chrysanthemum indicum.
AID1139297Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced COX2 protein expression at 10 uM after 16 hrs by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139296Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS protein expression at 40 uM after 16 hrs by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139306Inhibition of LPS-induced NFkappaB P50 protein nuclear translocation in mouse RAW264.7 cells at 40 uM after 30 mins by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139305Inhibition of LPS-induced NFkappaB P50 protein nuclear translocation in mouse RAW264.7 cells at 20 uM after 30 mins by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139316Inhibition of LPS-induced NF-kappaB p65 binding to DNA in mouse RAW264.7 cells at 10 to 40 uM after 1.5 hrs by spectrophotometry in presence of mutant oligonucleotide2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139295Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS protein expression at 20 uM after 16 hrs by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139324Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced TNF-alpha mRNA expression at 40 uM after 4 hrs by RT-PCR analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139318Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced TNF-alpha protein expression at 20 uM after 4 hrs by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139285Antiinflammatory activity in rat paw edema model assessed as inhibition of carrageenan-induced iNOS protein expression in paw tissue at 20 mg/kg, po administered 30 mins prior to carrageenan challenge measured after 6 hrs by Western blotting analysis rela2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139292Antiinflammatory activity in ICR mouse ear edema model assessed as inhibition of TPA-induced COX2 protein expression in ear tissue at 10 to 20 mg/kg, po administered 30 mins prior to TPA challenge measured after 4 hrs by Western blotting analysis relative2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139319Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced TNF-alpha protein expression at 40 uM after 4 hrs by Western blotting analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
AID1139327Inhibition LPS-induced JNK1/2 phosphorylation at Thr183/Tyr15 in mouse RAW264.7 cells at 20 uM administered 30 mins prior to LPS challenge measured after 30 mins by Western blotting analysis2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (33.33)24.3611
2020's5 (55.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.28 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index34.57 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (31.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
celecoxib
[no description available]		2.110organofluorine compound;
pyrazoles;
sulfonamide;
toluenes		cyclooxygenase 2 inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		2.110aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
omega-n-methylarginine
omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.		2.110amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.110prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.1510cysteiniumfundamental metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Anasarca
[description not available]		02.110
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.110
Skin Aging
The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.		03.5240
Airflow Obstruction, Chronic
[description not available]		02.610
Emphysema
A pathological accumulation of air in tissues or organs.		07.610
Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.		02.610
Innate Inflammatory Response
[description not available]		02.1510
Nervous System Disorders
[description not available]		02.1510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.1510
Nervous System Diseases
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.		02.1510