Compounds > ecumicin
Page last updated: 2024-11-13

ecumicin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ecumicin: antitubercular from Nonomuraea sp. MJM5123; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID101894301
CHEMBL ID4166169
MeSH IDM000604189

Synonyms (2)

Synonym
ecumicin
CHEMBL4166169

Research Excerpts

Overview

Ecumicin is a novel anti-tuberculosis agent produced by Nonomuraea sp. It is a potent inhibitor of Mycobacterium tuberculosis.

ExcerptReferenceRelevance
"Ecumicin is a well-known and potent inhibitor of Mycobacterium tuberculosis. "( Mutation analysis of the interactions between Mycobacterium tuberculosis caseinolytic protease C1 (ClpC1) and ecumicin.
Ha, NR; Jung, IP; Kim, AR; Kim, SH; Yoon, MY, 2017)		2.11
"Ecumicin is a novel anti-tuberculosis agent produced by Nonomuraea sp. "( Improvement of the productivity of ecumicin, a novel anti-tuberculosis agent, from new Nonomuraea sp. MJM5123.
Jin, YY; Kim, JY; Lee, H; Suh, JW; Yang, SH, 2016)		2.15

Actions

ExcerptReferenceRelevance
"Ecumicin can generate an abnormal ClpC1 component, which cannot form normal ClpC1/ClpP1/ClpP2, via two different modes."( Identification of the inhibitory mechanism of ecumicin and rufomycin 4-7 on the proteolytic activity of Mycobacterium tuberculosis ClpC1/ClpP1/ClpP2 complex.
Cao, J; Cho, S; Duc, NM; Hong, J; Jeong, BC; Jeong, C; Lee, H; Shetye, G; Suh, JW, 2023)		1.89
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1827075Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in human THP-1 cells assessed as log reduction in bacterial growth at 10 uM incubated for 3 to 4 weeks by intracellular killing assay2022Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A.
AID1503710Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by Alamar blue assay2017Journal of natural products, 10-27, Volume: 80, Issue:10
Structural Sequencing of Oligopeptides Aided by
AID1827046Antimycobacterial activity against Mycobacterium tuberculosis mc2 6230 measured after 7 days2022Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (60.00)24.3611
2020's4 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.83

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.83 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.83)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.4110carbohydrazideantitubercular agent;
drug allergen
terpestacin
terpestacin: structure given in first source; isolated from Arthrinium; inhibits syncytium (giant cell) formation		3.2310secondary alcohol
glucopiericidin a
glucopiericidin A: from Streptomyces pactum S48727 as co-metabolite of piericidin A(1); structure given in first source; glycoside antibiotic		3.2310
ohmyungsamycin a
ohmyungsamycin A: isolated from Streptomyces sp.; structure in first source		2.7220
ohmyungsamycin b
ohmyungsamycin B: isolated from Streptomyces sp.; structure in first source		2.4110
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.4110cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Koch's Disease
[description not available]		02.5520
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		07.5520