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ohmyungsamycin a

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Description

ohmyungsamycin A: isolated from Streptomyces sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID73292459
CHEMBL ID4467358
MeSH IDM000595271

Synonyms (2)

Synonym
CHEMBL4467358
ohmyungsamycin a
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (85)

Assay IDTitleYearJournalArticle
AID1546731Downregulation of DKK1 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546721Downregulation of PEG10 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546738Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at sub-G1 phase at 10 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 0.9%)
AID1546737Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 10 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 25.1%)
AID1546724Downregulation of TMSB15A gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546762Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 54.7%)
AID1546735Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 10 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 43.3%)
AID1546718Downregulation of BMP4 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546765Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at sub-G1 phase at 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 4.8%)
AID1546760Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 15.7%)
AID1546728Downregulation of HSPA1A gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546750Downregulation of MCM4 protein expression in human HCT116 cells at 5 to 20 uM after 24 hrs by Western blot analysis
AID1546717Downregulation of DSCC1 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546726Downregulation of HSPA1B gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546720Downregulation of CYP24A1 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546756Modulation of Skp2-p27 Axis in human HCT116 cells assessed as upregulation of p27 expression after 24 hrs by Western blot analysis
AID1546730Downregulation of KITLG gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546763Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 21.2%)
AID1546705Antiproliferative activity against human HCT116 cells after 72 hrs by sulforhodamine B assay
AID1546754Effect on Cul1 expression in human HCT116 cells at 5 to 20 uM after 24 hrs by Western blot analysis
AID1546747Decrease in cell cycle associated protein expression in human HCT116 cells assessed as reduction in CDK4 expression at 5 to 20 uM after 24 hrs by Western blot analysis
AID1546722Downregulation of HIST1H2BM gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546784In vivo modulation of Skp2-p27 axis in tumor of BALB/c mouse xenografted with human HCT116 cells assessed as upregulation of p27 mRNA level at 5 to 10 m/kg, ip administered thrice a week for 3.5 weeks by RT-PCR method
AID1546777Induction of apoptosis in human HCT116 cells assessed as reduction in survivin level at 5 to 20 uM after 24 hrs by Western blot analysis
AID1546785In vivo modulation of Skp2-p27 axis in tumor of BALB/c nude mouse xenografted with human HCT116 cells assessed as downregulation of Skp2 level at 5 to 10 m/kg, ip administered thrice a week for 3.5 weeks by Western blot analysis
AID1546759Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 21.2%)
AID1546782In vivo modulation of Skp2-p27 axis in tumor of BALB/c nude mouse xenografted with human HCT116 cells assessed as downregulation of Skp2 mRNA level at 5 to 10 m/kg, ip administered thrice a week for 3.5 weeks by RT-PCR method
AID1546776Induction of apoptosis in human HCT116 cells assessed as reduction in Bid level at 5 to 20 uM after 24 hrs by Western blot analysis
AID1546748Decrease in cell cycle associated protein expression in human HCT116 cells assessed as reduction in CDK6 expression at 5 to 20 uM after 24 hrs by Western blot analysis
AID1546755Modulation of Skp2-p27 Axis in human HCT116 cells assessed as upregulation of p21 expression after 24 hrs by Western blot analysis
AID1546709Antiproliferative activity against human MRC5 cells after 72 hrs by sulforhodamine B assay
AID1546732Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 5 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 26.8%)
AID1546766Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 20 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 54.7%)
AID1546746Decrease in cell cycle associated protein expression in human HCT116 cells assessed as reduction in cyclin D1 expression at 5 to 20 uM after 24 hrs by Western blot analysis
AID1546703Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 5 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 43.3%)
AID1546723Downregulation of GINS2 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546772Induction of apoptosis in human HCT116 cells assessed as reduction in uncleaved full length caspase 8 level after 24 hrs by Western blot analysis
AID1546773Induction of apoptosis in human HCT116 cells assessed as reduction in uncleaved full length caspase 7 level after 24 hrs by Western blot analysis
AID1546706Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
AID1546767Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 20 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 21.2%)
AID1546771Induction of apoptosis in human HCT116 cells assessed as increase in cleaved caspase 7 level after 24 hrs by Western blot analysis
AID1546714Downregulation of MCM5 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546786In vivo modulation of MCM4 in tumor of BALB/c nude mouse xenografted with human HCT116 cells assessed as downregulation of MCM4 level at 5 to 10 m/kg, ip administered thrice a week for 3.5 weeks by Western blot analysis
AID1546770Induction of apoptosis in human HCT116 cells assessed as increase in cleaved caspase 8 level after 24 hrs by Western blot analysis
AID1546769Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at sub-G1 phase at 20 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 4.8%)
AID1546713Downregulation of MCM4 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546744Decrease in cell cycle associated protein expression in human HCT116 cells assessed as reduction in cyclin E expression at 5 to 20 uM after 24 hrs by Western blot analysis
AID1546734Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at sub-G1 phase at 5 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 0.9%)
AID1546753Effect on Skp1 expression in human HCT116 cells at 5 to 20 uM after 24 hrs by Western blot analysis
AID1546708Antiproliferative activity against human SNU638 cells after 72 hrs by sulforhodamine B assay
AID1546757Modulation of Skp2-p27 Axis in human HCT116 cells assessed as reduction in Skp2 mRNA level at 5 to 20 uM after 12 hrs by real-time PCR method
AID1546751Downregulation of cyclin E2 mRNA expression in human HCT116 cells after 12 hrs by RT-PCR method
AID1546783In vivo modulation of MCM4 in tumor of BALB/c nude mouse xenografted with human HCT116 cells assessed as downregulation of MCM4 mRNA level at 5 to 10 m/kg, ip administered thrice a week for 3.5 weeks by RT-PCR method
AID1546743Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase incubated for 18 hrs by propidium iodide staining based flow cytometry
AID1546739Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 20 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 43.3%)
AID1546710Induction of morphological changes in human HCT116 cells assessed as appearance of shrunken cells at 4 to 20 uM by inverted phase-contrast microscopic method
AID1546736Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 10 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 26.8%)
AID1546758Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 54.7%)
AID1546712Downregulation of SKP2 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546779Toxicity in BALB/c nude mouse assessed as changes in body weight at 5 to 10 mg/kg, ip administered thrice a week for 3.5 weeks
AID1546761Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at sub-G1 phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 4.8%)
AID1546707Antiproliferative activity against human SKHEP1 cells after 72 hrs by sulforhodamine B assay
AID1546725Downregulation of FAM111B gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546745Decrease in cell cycle associated protein expression in human HCT116 cells assessed as reduction in CDK2 expression at 5 to 20 uM after 24 hrs by Western blot analysis
AID1546768Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 20 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 15.7%)
AID1546774Induction of apoptosis in human HCT116 cells assessed as increase in cleaved PARP level at 20 uM after 24 hrs by Western blot analysis
AID1546729Downregulation of SCARA3 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546716Downregulation of CCNE2 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546727Downregulation of INSIG1 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546742Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at sub-G1 phase at 20 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 0.9%)
AID1546711Induction of morphological changes in human HCT116 cells assessed as appearance of pin-point shape cells at 4 to 20 uM by inverted phase-contrast microscopic method
AID1546704Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
AID1546752Modulation of Skp2-p27 Axis in human HCT116 cells assessed as downregulation of Skp2 expression at 5 to 20 uM after 24 hrs by Western blot analysis
AID1546778Antitumor activity against human HCT116 cells xenografted in BALB/c nude mouse assessed as reduction in tumor volume at 5 to 10 mg/kg, ip administered thrice a week for 3.5 weeks and measured every 3 to 4 weeks by caliper method
AID1546764Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 15.7%)
AID1546741Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 20 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 25.1%)
AID1546749Downregulation of MCM4 mRNA expression in human HCT116 cells after 12 hrs by RT-PCR method
AID1546719Downregulation of CDCA7 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546780Antitumor activity against human HCT116 cells xenografted in BALB/c nude mouse assessed as tumor weight at 5 mg/kg, ip administered thrice a week for 3.5 weeks measured on last day (Rvb = 100%)
AID1546733Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 5 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 25.1%)
AID1546740Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 20 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 26.8%)
AID1546715Downregulation of MCM10 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control
AID1546787In vivo modulation of Skp2-p27 axis in tumor of BALB/c nude mouse xenografted with human HCT116 cells assessed as upregulation of p27 level at 5 to 10 m/kg, ip administered thrice a week for 3.5 weeks by Western blot analysis
AID1546781Antitumor activity against human HCT116 cells xenografted in BALB/c nude mouse assessed as tumor weight at 10 mg/kg, ip administered thrice a week for 3.5 weeks measured on last day (Rvb = 100%)
AID1546775Induction of apoptosis in human HCT116 cells assessed as reduction in Bcl-2 level at 5 to 20 uM after 24 hrs by Western blot analysis
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (62.50)24.3611
2020's3 (37.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.37 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.56 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]