| Assay ID | Title | Year | Journal | Article |
|---|
| AID1546731 | Downregulation of DKK1 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546721 | Downregulation of PEG10 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546738 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at sub-G1 phase at 10 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 0.9%) | | | |
| AID1546737 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 10 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 25.1%) | | | |
| AID1546724 | Downregulation of TMSB15A gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546762 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 54.7%) | | | |
| AID1546735 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 10 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 43.3%) | | | |
| AID1546718 | Downregulation of BMP4 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546765 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at sub-G1 phase at 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 4.8%) | | | |
| AID1546760 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 15.7%) | | | |
| AID1546728 | Downregulation of HSPA1A gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546750 | Downregulation of MCM4 protein expression in human HCT116 cells at 5 to 20 uM after 24 hrs by Western blot analysis | | | |
| AID1546717 | Downregulation of DSCC1 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546726 | Downregulation of HSPA1B gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546720 | Downregulation of CYP24A1 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546756 | Modulation of Skp2-p27 Axis in human HCT116 cells assessed as upregulation of p27 expression after 24 hrs by Western blot analysis | | | |
| AID1546730 | Downregulation of KITLG gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546763 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 21.2%) | | | |
| AID1546705 | Antiproliferative activity against human HCT116 cells after 72 hrs by sulforhodamine B assay | | | |
| AID1546754 | Effect on Cul1 expression in human HCT116 cells at 5 to 20 uM after 24 hrs by Western blot analysis | | | |
| AID1546747 | Decrease in cell cycle associated protein expression in human HCT116 cells assessed as reduction in CDK4 expression at 5 to 20 uM after 24 hrs by Western blot analysis | | | |
| AID1546722 | Downregulation of HIST1H2BM gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546784 | In vivo modulation of Skp2-p27 axis in tumor of BALB/c mouse xenografted with human HCT116 cells assessed as upregulation of p27 mRNA level at 5 to 10 m/kg, ip administered thrice a week for 3.5 weeks by RT-PCR method | | | |
| AID1546777 | Induction of apoptosis in human HCT116 cells assessed as reduction in survivin level at 5 to 20 uM after 24 hrs by Western blot analysis | | | |
| AID1546785 | In vivo modulation of Skp2-p27 axis in tumor of BALB/c nude mouse xenografted with human HCT116 cells assessed as downregulation of Skp2 level at 5 to 10 m/kg, ip administered thrice a week for 3.5 weeks by Western blot analysis | | | |
| AID1546759 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 21.2%) | | | |
| AID1546782 | In vivo modulation of Skp2-p27 axis in tumor of BALB/c nude mouse xenografted with human HCT116 cells assessed as downregulation of Skp2 mRNA level at 5 to 10 m/kg, ip administered thrice a week for 3.5 weeks by RT-PCR method | | | |
| AID1546776 | Induction of apoptosis in human HCT116 cells assessed as reduction in Bid level at 5 to 20 uM after 24 hrs by Western blot analysis | | | |
| AID1546748 | Decrease in cell cycle associated protein expression in human HCT116 cells assessed as reduction in CDK6 expression at 5 to 20 uM after 24 hrs by Western blot analysis | | | |
| AID1546755 | Modulation of Skp2-p27 Axis in human HCT116 cells assessed as upregulation of p21 expression after 24 hrs by Western blot analysis | | | |
| AID1546709 | Antiproliferative activity against human MRC5 cells after 72 hrs by sulforhodamine B assay | | | |
| AID1546732 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 5 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 26.8%) | | | |
| AID1546766 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 20 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 54.7%) | | | |
| AID1546746 | Decrease in cell cycle associated protein expression in human HCT116 cells assessed as reduction in cyclin D1 expression at 5 to 20 uM after 24 hrs by Western blot analysis | | | |
| AID1546703 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 5 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 43.3%) | | | |
| AID1546723 | Downregulation of GINS2 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546772 | Induction of apoptosis in human HCT116 cells assessed as reduction in uncleaved full length caspase 8 level after 24 hrs by Western blot analysis | | | |
| AID1546773 | Induction of apoptosis in human HCT116 cells assessed as reduction in uncleaved full length caspase 7 level after 24 hrs by Western blot analysis | | | |
| AID1546706 | Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay | | | |
| AID1546767 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 20 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 21.2%) | | | |
| AID1546771 | Induction of apoptosis in human HCT116 cells assessed as increase in cleaved caspase 7 level after 24 hrs by Western blot analysis | | | |
| AID1546714 | Downregulation of MCM5 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546786 | In vivo modulation of MCM4 in tumor of BALB/c nude mouse xenografted with human HCT116 cells assessed as downregulation of MCM4 level at 5 to 10 m/kg, ip administered thrice a week for 3.5 weeks by Western blot analysis | | | |
| AID1546770 | Induction of apoptosis in human HCT116 cells assessed as increase in cleaved caspase 8 level after 24 hrs by Western blot analysis | | | |
| AID1546769 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at sub-G1 phase at 20 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 4.8%) | | | |
| AID1546713 | Downregulation of MCM4 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546744 | Decrease in cell cycle associated protein expression in human HCT116 cells assessed as reduction in cyclin E expression at 5 to 20 uM after 24 hrs by Western blot analysis | | | |
| AID1546734 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at sub-G1 phase at 5 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 0.9%) | | | |
| AID1546753 | Effect on Skp1 expression in human HCT116 cells at 5 to 20 uM after 24 hrs by Western blot analysis | | | |
| AID1546708 | Antiproliferative activity against human SNU638 cells after 72 hrs by sulforhodamine B assay | | | |
| AID1546757 | Modulation of Skp2-p27 Axis in human HCT116 cells assessed as reduction in Skp2 mRNA level at 5 to 20 uM after 12 hrs by real-time PCR method | | | |
| AID1546751 | Downregulation of cyclin E2 mRNA expression in human HCT116 cells after 12 hrs by RT-PCR method | | | |
| AID1546783 | In vivo modulation of MCM4 in tumor of BALB/c nude mouse xenografted with human HCT116 cells assessed as downregulation of MCM4 mRNA level at 5 to 10 m/kg, ip administered thrice a week for 3.5 weeks by RT-PCR method | | | |
| AID1546743 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase incubated for 18 hrs by propidium iodide staining based flow cytometry | | | |
| AID1546739 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 20 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 43.3%) | | | |
| AID1546710 | Induction of morphological changes in human HCT116 cells assessed as appearance of shrunken cells at 4 to 20 uM by inverted phase-contrast microscopic method | | | |
| AID1546736 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 10 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 26.8%) | | | |
| AID1546758 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G0/G1 phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 54.7%) | | | |
| AID1546712 | Downregulation of SKP2 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546779 | Toxicity in BALB/c nude mouse assessed as changes in body weight at 5 to 10 mg/kg, ip administered thrice a week for 3.5 weeks | | | |
| AID1546761 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at sub-G1 phase at 5 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 4.8%) | | | |
| AID1546707 | Antiproliferative activity against human SKHEP1 cells after 72 hrs by sulforhodamine B assay | | | |
| AID1546725 | Downregulation of FAM111B gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546745 | Decrease in cell cycle associated protein expression in human HCT116 cells assessed as reduction in CDK2 expression at 5 to 20 uM after 24 hrs by Western blot analysis | | | |
| AID1546768 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 20 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 15.7%) | | | |
| AID1546774 | Induction of apoptosis in human HCT116 cells assessed as increase in cleaved PARP level at 20 uM after 24 hrs by Western blot analysis | | | |
| AID1546729 | Downregulation of SCARA3 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546716 | Downregulation of CCNE2 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546727 | Downregulation of INSIG1 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546742 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at sub-G1 phase at 20 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 0.9%) | | | |
| AID1546711 | Induction of morphological changes in human HCT116 cells assessed as appearance of pin-point shape cells at 4 to 20 uM by inverted phase-contrast microscopic method | | | |
| AID1546704 | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay | | | |
| AID1546752 | Modulation of Skp2-p27 Axis in human HCT116 cells assessed as downregulation of Skp2 expression at 5 to 20 uM after 24 hrs by Western blot analysis | | | |
| AID1546778 | Antitumor activity against human HCT116 cells xenografted in BALB/c nude mouse assessed as reduction in tumor volume at 5 to 10 mg/kg, ip administered thrice a week for 3.5 weeks and measured every 3 to 4 weeks by caliper method | | | |
| AID1546764 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 10 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 15.7%) | | | |
| AID1546741 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 20 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 25.1%) | | | |
| AID1546749 | Downregulation of MCM4 mRNA expression in human HCT116 cells after 12 hrs by RT-PCR method | | | |
| AID1546719 | Downregulation of CDCA7 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546780 | Antitumor activity against human HCT116 cells xenografted in BALB/c nude mouse assessed as tumor weight at 5 mg/kg, ip administered thrice a week for 3.5 weeks measured on last day (Rvb = 100%) | | | |
| AID1546733 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase at 5 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 25.1%) | | | |
| AID1546740 | Induction of cell cycle arrest in human HCT116 cells assessed as accumulation at S phase at 20 uM incubated for 18 hrs by propidium iodide staining based flow cytometry (Rvb = 26.8%) | | | |
| AID1546715 | Downregulation of MCM10 gene expression in human HCT116 cells assessed as fold change at 15 uM incubated for 24 hrs by cDNA microarray analysis relative to control | | | |
| AID1546787 | In vivo modulation of Skp2-p27 axis in tumor of BALB/c nude mouse xenografted with human HCT116 cells assessed as upregulation of p27 level at 5 to 10 m/kg, ip administered thrice a week for 3.5 weeks by Western blot analysis | | | |
| AID1546781 | Antitumor activity against human HCT116 cells xenografted in BALB/c nude mouse assessed as tumor weight at 10 mg/kg, ip administered thrice a week for 3.5 weeks measured on last day (Rvb = 100%) | | | |
| AID1546775 | Induction of apoptosis in human HCT116 cells assessed as reduction in Bcl-2 level at 5 to 20 uM after 24 hrs by Western blot analysis | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |