Diheptyl phthalate (DHP) is a plasticizer used in various applications, including PVC products. It is synthesized through the esterification reaction between phthalic anhydride and 1-heptanol. DHP is known to have low volatility and good compatibility with PVC, making it a suitable plasticizer for various purposes. It is studied because of its potential environmental and health effects, as it can leach from plastic products and potentially contaminate the environment. Research is ongoing to investigate its toxicity and bioaccumulation potential in living organisms.'
diheptyl phthalate : The diheptyl ester of benzene-1,2-dicarboxylic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 19284 |
| CHEMBL ID | 2140472 |
| CHEBI ID | 34677 |
| SCHEMBL ID | 124977 |
| MeSH ID | M0237386 |
| Synonym |
|---|
| BIDD:ER0462 |
| AKOS015838912 |
| phthalic acid, diheptyl ester |
| 1,2-benzenedicarboxylic acid, diheptyl ester , |
| diheptyl ester of phthalic acid |
| heptyl phthalate |
| di-n-heptylphthalate |
| diheptyl 1,2-benzenedicarboxylate |
| hsdb 344 |
| brn 2336623 |
| einecs 222-885-4 |
| n-diheptyl phthalate |
| di-n-heptyl phthalate |
| 3648-21-3 |
| diheptyl phthalate, 97% |
| NCGC00164188-01 |
| diheptyl phthalate |
| 68515-44-6 |
| diheptyl benzene-1,2-dicarboxylate |
| CHEBI:34677 , |
| 1,2-benzenedicarboxylic acid diheptyl ester |
| phthalic acid diheptyl ester |
| unii-ie05vo8p8p |
| ie05vo8p8p , |
| 1,2-benzenedicarboxylic acid, 1,2-diheptyl ester |
| FT-0624936 |
| EPITOPE ID:140106 |
| S10653 |
| diheptyl phthalate [hsdb] |
| SCHEMBL124977 |
| CHEMBL2140472 |
| JQCXWCOOWVGKMT-UHFFFAOYSA-N |
| NCGC00356968-01 |
| dtxcid608662 |
| cas-3648-21-3 |
| tox21_303892 |
| dtxsid8040779 , |
| W-109923 |
| c22h34o4 |
| mfcd00043680 |
| diheptyl phthalate, analytical standard |
| phthalic acid, bis-n-heptyl ester |
| 1,2-benzenedicarboxylic acid, diisoheptyl ester (9ci); diisoheptyl phthalate; jayflex 77; jayflex dihp 77 |
| Q2943515 |
| SY040431 |
| phthalic acid, bis-n-heptyl ester 100 microg/ml in acetonitrile |
| di-n-heptyl phthalate-3,4,5,6-d4 |
| CS-W011819 |
| diheptylphthalate |
| HY-W011103 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " DHPP and DnOP had no adverse effect on maternal feed consumption and body weight gain, or on the incidence of post-implantation loss and fetal body weight." | ( Prenatal developmental toxicity studies on di-n-heptyl and di-n-octyl phthalates in Sprague-Dawley rats. Gallissot, F; Roudot, AC; Sabaté, JP; Saillenfait, AM, 2011) | 0.37 |
| Class | Description |
|---|---|
| phthalate ester | |
| diester | A diester is a compound containing two ester groups. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.3064 | 0.0007 | 14.5928 | 83.7951 | AID1259369 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 8.0663 | 0.0010 | 22.6508 | 76.6163 | AID1224838; AID1224839; AID1224893 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 76.9588 | 0.0006 | 27.2152 | 1,122.0200 | AID651741 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (21.98) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||