diheptyl phthalate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Diheptyl phthalate (DHP) is a plasticizer used in various applications, including PVC products. It is synthesized through the esterification reaction between phthalic anhydride and 1-heptanol. DHP is known to have low volatility and good compatibility with PVC, making it a suitable plasticizer for various purposes. It is studied because of its potential environmental and health effects, as it can leach from plastic products and potentially contaminate the environment. Research is ongoing to investigate its toxicity and bioaccumulation potential in living organisms.'

diheptyl phthalate : The diheptyl ester of benzene-1,2-dicarboxylic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	19284
CHEMBL ID	2140472
CHEBI ID	34677
SCHEMBL ID	124977
MeSH ID	M0237386

Synonyms (50)

Synonym
BIDD:ER0462
AKOS015838912
phthalic acid, diheptyl ester
1,2-benzenedicarboxylic acid, diheptyl ester ,
diheptyl ester of phthalic acid
heptyl phthalate
di-n-heptylphthalate
diheptyl 1,2-benzenedicarboxylate
hsdb 344
brn 2336623
einecs 222-885-4
n-diheptyl phthalate
di-n-heptyl phthalate
3648-21-3
diheptyl phthalate, 97%
NCGC00164188-01
diheptyl phthalate
68515-44-6
diheptyl benzene-1,2-dicarboxylate
CHEBI:34677 ,
1,2-benzenedicarboxylic acid diheptyl ester
phthalic acid diheptyl ester
unii-ie05vo8p8p
ie05vo8p8p ,
1,2-benzenedicarboxylic acid, 1,2-diheptyl ester
FT-0624936
EPITOPE ID:140106
S10653
diheptyl phthalate [hsdb]
SCHEMBL124977
CHEMBL2140472
JQCXWCOOWVGKMT-UHFFFAOYSA-N
NCGC00356968-01
dtxcid608662
cas-3648-21-3
tox21_303892
dtxsid8040779 ,
W-109923
c22h34o4
mfcd00043680
diheptyl phthalate, analytical standard
phthalic acid, bis-n-heptyl ester
1,2-benzenedicarboxylic acid, diisoheptyl ester (9ci); diisoheptyl phthalate; jayflex 77; jayflex dihp 77
Q2943515
SY040431
phthalic acid, bis-n-heptyl ester 100 microg/ml in acetonitrile
di-n-heptyl phthalate-3,4,5,6-d4
CS-W011819
diheptylphthalate
HY-W011103

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" DHPP and DnOP had no adverse effect on maternal feed consumption and body weight gain, or on the incidence of post-implantation loss and fetal body weight."	( Prenatal developmental toxicity studies on di-n-heptyl and di-n-octyl phthalates in Sprague-Dawley rats. Gallissot, F; Roudot, AC; Sabaté, JP; Saillenfait, AM, 2011)	0.37

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

Class	Description
phthalate ester
diester	A diester is a compound containing two ester groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
GLI family zinc finger 3	Homo sapiens (human)	Potency	0.3064	0.0007	14.5928	83.7951	AID1259369
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	8.0663	0.0010	22.6508	76.6163	AID1224838; AID1224839; AID1224893
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	76.9588	0.0006	27.2152	1,122.0200	AID651741
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (12.50)	18.2507
2000's	4 (50.00)	29.6817
2010's	2 (25.00)	24.3611
2020's	1 (12.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.98

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	21.98 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.88 (4.65)
Search Engine Demand Index	18.60 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (21.98)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
naphthalene [no description available]	2.02	1	naphthalenes; ortho-fused bicyclic arene	apoptosis inhibitor; carcinogenic agent; environmental contaminant; mouse metabolite; plant metabolite; volatile oil component
phthalic acid phthalic acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7178. phthalic acid : A benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions.	2.46	2	benzenedicarboxylic acid	human xenobiotic metabolite
dibutyl phthalate Dibutyl Phthalate: A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.. dibutyl phthalate : A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.	2	1	diester; phthalate ester	EC 3.2.1.20 (alpha-glucosidase) inhibitor; environmental contaminant; metabolite; plasticiser; teratogenic agent
benzophenone benzophenone : The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups.	2.02	1	benzophenones	photosensitizing agent; plant metabolite
2,4,6-trichloroanisole 2,4,6-trichloroanisole: Cork taint compound. 2,4,6-trichloroanisole : A monomethoxybenzene that is 1,3,5-trichlorobenzene in which one of the hydrogens is replaced by a methoxy group.	2.02	1	monomethoxybenzene; trichlorobenzene
diethylhexyl phthalate Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.. bis(2-ethylhexyl) phthalate : A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.	2	1	diester; phthalate ester	androstane receptor agonist; apoptosis inhibitor; plasticiser
di-n-octyl phthalate di-n-octyl phthalate: plasticizer	2.06	1	diester; phthalate ester
dioctyl adipate [no description available]	2	1	carboxylic ester
diisodecyl phthalate monodesmethylisoproturon: a metabolite of isoproturon; structure in first source	7.25	1	diester; phthalate ester
2,2-dimethoxy-2-phenylacetophenone [no description available]	2.02	1
diisononyl phthalate diisononyl phthalate: dielectric (electric insulating) fluid. diisononyl phthalate : The diisononyl ester of benzene-1,2-dicarboxylic acid.	2	1	diester; phthalate ester	plasticiser

Condition	Relationship Strength	Studies
Cancer of Liver [description not available]	2.46	2
Condition, Preneoplastic [description not available]	2.46	2
Liver Neoplasms Tumors or cancer of the LIVER.	2.46	2
Precancerous Conditions Pathological conditions that tend eventually to become malignant.	2.46	2
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.45	2
Body Weight, Fetal [description not available]	2.03	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.4	2
Delayed Effects, Prenatal Exposure [description not available]	2.03	1

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