Diformyl dapsone is a synthetic derivative of dapsone, an antibiotic commonly used to treat leprosy. It was initially developed as a potential treatment for leishmaniasis, but it also shows promising activity against other parasitic diseases, including malaria and toxoplasmosis. Studies have shown that diformyl dapsone inhibits the growth of Leishmania parasites by interfering with their folate metabolism. Its unique chemical structure allows it to potentially cross the blood-brain barrier, which makes it particularly interesting for treating parasitic diseases that affect the central nervous system. Further research is needed to fully understand its efficacy, safety, and potential therapeutic applications in various parasitic infections.'
diformyl dapsone: minor descriptor (75-84); on-line & Index Medicus search DAPSONE/AA (75-84) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 23230 |
| CHEMBL ID | 2001327 |
| SCHEMBL ID | 3955572 |
| MeSH ID | M0262646 |
| Synonym |
|---|
| diformyl dapsone |
| NSC53674 , |
| formilone |
| wr 6798 |
| formamide,n'-(sulfonyldi-4,1-phenylene)bis- |
| dfdds |
| 4,4'-diformamidodiphenyl sulfone |
| formanilide,4'''-sulfonylbis- |
| diformyl diaminodiphenylsulfone |
| wln: vhmr dswr dmvh |
| nsc-53674 |
| sulfone, bis(n-formyl-p-aminophenyl) |
| p,p'-sulfonylbisformanilide |
| diformyl-4,4'-sulfonyldianiline |
| formanilide,4'''-sulfonyldi- |
| n,p'-diaminodiphenylsulfone |
| NCI60_004323 |
| formamide, n,n'-(sulfonyldi-4,1-phenylene)bis- |
| n-[4-(4-formamidophenyl)sulfonylphenyl]formamide |
| DFD , |
| 6784-25-4 |
| diformyldapsone |
| nsc 53674 |
| brn 2815334 |
| n,n'-diformyl-p,p'-diaminodiphenylsulfone |
| formanilide, 4',4'''-sulfonylbis- |
| formanilide, 4',4'''-sulfonyldi- |
| unii-tf8f6obi8q |
| 4,4'-diformamidodiphenylsulfone |
| tf8f6obi8q , |
| wr-6798 |
| 4,4'-sulfonylbisformanilide |
| 3-13-00-01270 (beilstein handbook reference) |
| diformamido diphenylsulfone |
| SCHEMBL3955572 |
| CHEMBL2001327 |
| DTXSID70218079 |
| formanilide, 4,4'-sulfonylbis- |
| p,p'-sulfonylbis(formanilide) |
| n,n'-(sulfonylbis(4,1-phenylene))diformamide |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 4 (80.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.66) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||