cotarnine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6715 |
| CHEMBL ID | 4745550 |
| CHEBI ID | 166583 |
| SCHEMBL ID | 679713 |
| MeSH ID | M0045839 |
| Synonym |
|---|
| 4-methoxy-6-methyl-7,8-dihydro-5h-[1,3]dioxolo[4,5-g]isoquinolin-5-ol |
| 82-54-2 |
| CHEBI:166583 |
| nsc-121978 |
| 59760-32-6 |
| nsc121978 |
| cotarnine |
| 1,3-dioxolo(4,5-g)isoquinolin-5-ol, 5,6,7,8-tetrahydro-4-methoxy-6-methyl- |
| cotarnin |
| einecs 201-429-8 |
| 5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-ol |
| brn 0022879 |
| AKOS005605723 |
| STK693623 |
| 4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-ol |
| 79v56tdi6g , |
| 4-27-00-06448 (beilstein handbook reference) |
| unii-79v56tdi6g |
| FT-0624071 |
| (+/-)-cotarnine |
| cotarnine [mi] |
| cotarnine, (+/-)- |
| cotarnine [who-dd] |
| SCHEMBL679713 |
| 5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-ol |
| PAPMYQLKLNRZIR-UHFFFAOYSA-N |
| 4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-ol # |
| 4-methoxy-6-methyl-7,8-dihydro-5h-[1,3]dioxol[4,5-g]isoquinolin-5-ol |
| 1,3-dioxolo[4,5-g]isoquinolin-5-ol,5,6,7,8-tetrahydro-4-methoxy-6-methyl- |
| DTXSID80274484 |
| sr-01000884006 |
| SR-01000884006-1 |
| mfcd00190616 |
| 99781-53-0 |
| 4-methoxy-6-methyl-2h,5h,6h,7h,8h-[1,3]dioxolo[4,5-g]isoquinolin-5-ol |
| NS-03227 |
| Q27266783 |
| 4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ol |
| XC160978 |
| 4-methoxy-6-methyl-5,6,7,8-tetrahydro-2h-[1,3]dioxolo[4,5-g]isoquinolin-5-ol |
| DTXSID40871559 |
| CHEMBL4745550 |
| EN300-302336 |
| Class | Description |
|---|---|
| isoquinolines | A class of organic heteropolycyclic compound consisting of isoquinoline and its substitution derivatives. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Substance | Description | Relationhip Strength | Studies | Trials | Classes | Roles |
|---|---|---|---|---|---|---|
| hydrastinine | [no description available] | medium | 1 | 0 | ||
| hydrastine | [no description available] | medium | 1 | 0 | isoquinolines | metabolite |
| noscapine | [no description available] | medium | 3 | 0 | aromatic ether; benzylisoquinoline alkaloid; cyclic acetal; isobenzofuranone; organic heterobicyclic compound; organic heterotricyclic compound; tertiary amino compound | antineoplastic agent; antitussive; apoptosis inducer; plant metabolite |
| diphenhydramine hydrochloride | [no description available] | medium | 1 | 0 | hydrochloride; organoammonium salt | anti-allergic agent; antiemetic; antiparkinson drug; antipruritic drug; H1-receptor antagonist; local anaesthetic; muscarinic antagonist; sedative |
| betaine | [no description available] | medium | 1 | 0 | amino-acid betaine; glycine derivative | fundamental metabolite |
| narcotoline | [no description available] | medium | 1 | 0 | isoquinolines | |
| tritoqualine | [no description available] | medium | 1 | 0 | isoquinolines | |
| phenobarbital | [no description available] | medium | 1 | 0 | barbiturates | anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative |
| benzofurans | [no description available] | medium | 1 | 0 | ||
| beta-naphthoflavone | [no description available] | medium | 1 | 0 | extended flavonoid; naphtho-gamma-pyrone; organic heterotricyclic compound | aryl hydrocarbon receptor agonist |
| pk 11195 | [no description available] | low | 0 | 0 | aromatic amide; isoquinolines; monocarboxylic acid amide; monochlorobenzenes | antineoplastic agent |
| 5-aminoisoquinolinone | [no description available] | low | 0 | 0 | isoquinolines | |
| debrisoquin | [no description available] | low | 0 | 0 | carboxamidine; isoquinolines | adrenergic agent; antihypertensive agent; human metabolite; sympatholytic agent |
| ethaverine | [no description available] | low | 0 | 0 | isoquinolines | |
| n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide | [no description available] | low | 0 | 0 | isoquinolines; sulfonamide | |
| N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide | [no description available] | low | 0 | 0 | bromobenzenes; isoquinolines; olefinic compound; secondary amino compound; sulfonamide | EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor |
| 1-(5-isoquinolinesulfonyl)-2-methylpiperazine | [no description available] | low | 0 | 0 | isoquinolines; N-sulfonylpiperazine | EC 2.7.11.13 (protein kinase C) inhibitor |
| 1-(5-isoquinolinesulfonyl)piperazine | [no description available] | low | 0 | 0 | isoquinolines | |
| ha 1004 | [no description available] | low | 0 | 0 | isoquinolines | |
| fasudil | [no description available] | low | 0 | 0 | isoquinolines; N-sulfonyldiazepane | antihypertensive agent; calcium channel blocker; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; geroprotector; neuroprotective agent; nootropic agent; vasodilator agent |
| hydrocotarnine | [no description available] | low | 0 | 0 | isoquinolines | |
| nomifensine | [no description available] | low | 0 | 0 | isoquinolines | dopamine uptake inhibitor |
| 6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one | [no description available] | low | 0 | 0 | isoquinolines | |
| papaverine | [no description available] | low | 0 | 0 | benzylisoquinoline alkaloid; dimethoxybenzene; isoquinolines | antispasmodic drug; vasodilator agent |
| praziquantel | [no description available] | low | 0 | 0 | isoquinolines | |
| scriptaid | [no description available] | low | 0 | 0 | isoquinolines | |
| tilisolol | [no description available] | low | 0 | 0 | isoquinolines | |
| dimethisoquin | [no description available] | low | 0 | 0 | isoquinolines | |
| 1,2,3,4-tetrahydroisoquinoline | [no description available] | low | 0 | 0 | isoquinolines | |
| isoquinoline | [no description available] | low | 0 | 0 | azaarene; isoquinolines; mancude organic heterobicyclic parent; ortho-fused heteroarene | |
| cepharanthine | [no description available] | low | 0 | 0 | bisbenzylisoquinoline alkaloid; isoquinolines | |
| bicuculline | [no description available] | low | 0 | 0 | benzylisoquinoline alkaloid; isoquinoline alkaloid; isoquinolines | agrochemical; central nervous system stimulant; GABA-gated chloride channel antagonist; GABAA receptor antagonist; neurotoxin |
| isocarbostyril | [no description available] | low | 0 | 0 | isoquinolines | |
| salsolidine | [no description available] | low | 0 | 0 | isoquinolines | |
| laudanosine | [no description available] | low | 0 | 0 | isoquinolines | |
| 1-methylisoquinoline | [no description available] | low | 0 | 0 | isoquinolines | |
| heliamine | [no description available] | low | 0 | 0 | aromatic ether; diether; isoquinoline alkaloid; isoquinolines | plant metabolite |
| 1,2-dehydrosalsolinol | [no description available] | low | 0 | 0 | isoquinolines | |
| dehydroemetine | [no description available] | low | 0 | 0 | aromatic ether; isoquinolines; pyridoisoquinoline | antileishmanial agent; antimalarial; antiprotozoal drug |
| metocurine | [no description available] | low | 0 | 0 | isoquinolines | |
| thalicarpine | [no description available] | low | 0 | 0 | bisbenzylisoquinoline alkaloid; isoquinolines | |
| dimoxyline | [no description available] | low | 0 | 0 | isoquinolines | |
| 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline | [no description available] | low | 0 | 0 | isoquinolines | |
| coralyne | [no description available] | low | 0 | 0 | isoquinolines | |
| (3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-isobenzofuran-1-one | [no description available] | low | 0 | 0 | isoquinolines | |
| salsoline | [no description available] | low | 0 | 0 | isoquinolines | |
| isosalsoline | [no description available] | low | 0 | 0 | isoquinolines | |
| amonafide | [no description available] | low | 0 | 0 | isoquinolines | |
| daurisoline | [no description available] | low | 0 | 0 | isoquinolines | |
| magnocurarine | [no description available] | low | 0 | 0 | isoquinolines | |
| quinapril | [no description available] | low | 0 | 0 | dicarboxylic acid monoester; ethyl ester; isoquinolines; tertiary carboxamide | antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; prodrug |
| tretoquinol | [no description available] | low | 0 | 0 | isoquinolines | |
| moxaverine | [no description available] | low | 0 | 0 | isoquinolines | |
| tubulosine | [no description available] | low | 0 | 0 | beta-carbolines; isoquinoline alkaloid; isoquinolines; phenols; secondary amino compound; tertiary amino compound | |
| hernandezine | [no description available] | low | 0 | 0 | bisbenzylisoquinoline alkaloid; isoquinolines | |
| tetrandrine | [no description available] | low | 0 | 0 | bisbenzylisoquinoline alkaloid; isoquinolines | |
| dauricine | [no description available] | low | 0 | 0 | aromatic ether; bisbenzylisoquinoline alkaloid; isoquinolines; phenols; tertiary amino compound | plant metabolite |
| cherylline | [no description available] | low | 0 | 0 | isoquinolines | |
| gliquidone | [no description available] | low | 0 | 0 | isoquinolines | |
| 1-methyl-1,2,3,4-tetrahydroisoquinoline | [no description available] | low | 0 | 0 | isoquinolines | |
| laudanosoline | [no description available] | low | 0 | 0 | isoquinolines | |
| papaveraldine | [no description available] | low | 0 | 0 | isoquinolines | |
| corydaline | [no description available] | low | 0 | 0 | isoquinoline alkaloid; isoquinolines | |
| 4-hydroxydebrisoquin | [no description available] | low | 0 | 0 | carboxamidine; isoquinolines; secondary alcohol | metabolite |
| quinaprilat | [no description available] | low | 0 | 0 | dicarboxylic acid; isoquinolines; tertiary carboxamide | antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; vasodilator agent |
| cycleanine | [no description available] | low | 0 | 0 | bisbenzylisoquinoline alkaloid; isoquinolines | |
| dihydrotetrabenazine | [no description available] | low | 0 | 0 | isoquinolines | |
| 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | [no description available] | low | 0 | 0 | isoquinolines; organochlorine compound | |
| 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline | [no description available] | low | 0 | 0 | isoquinolines | |
| cki 7 | [no description available] | low | 0 | 0 | isoquinolines; organochlorine compound; primary amino compound; sulfonamide | EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor |
| pixantrone | [no description available] | low | 0 | 0 | isoquinolines | |
| isodibut | [no description available] | low | 0 | 0 | isoquinolines | |
| 3,4-dihydro-5-methyl-1(2h)-isoquinolinone | [no description available] | low | 0 | 0 | isoquinolines | |
| solifenacin | [no description available] | low | 0 | 0 | isoquinolines | |
| liensinine | [no description available] | low | 0 | 0 | isoquinolines | |
| trilobine | [no description available] | low | 0 | 0 | isoquinolines | |
| corynoline | [no description available] | low | 0 | 0 | benzophenanthridine alkaloid; cyclic acetal; isoquinolines; organic heterohexacyclic compound; secondary alcohol | antineoplastic agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; hepatoprotective agent; metabolite |
| minalrestat | [no description available] | low | 0 | 0 | isoquinolines | |
| pronuciferine | [no description available] | low | 0 | 0 | aromatic ether; cyclic ketone; isoquinoline alkaloid; isoquinolines; organic heterotetracyclic compound | plant metabolite |
| 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine | [no description available] | low | 0 | 0 | isoquinolines | |
| solifenacin succinate | [no description available] | low | 0 | 0 | isoquinolines | |
| berbamine | [no description available] | low | 0 | 0 | bisbenzylisoquinoline alkaloid; isoquinolines | |
| 2-(2-oxolanylmethyl)benzo[de]isoquinoline-1,3-dione | [no description available] | low | 0 | 0 | isoquinolines | |
| guatteguamerine | [no description available] | low | 0 | 0 | bisbenzylisoquinoline alkaloid; isoquinolines | |
| korupensamine-b | [no description available] | low | 0 | 0 | isoquinolines; naphthalenes | |
| obamegine | [no description available] | low | 0 | 0 | bisbenzylisoquinoline alkaloid; isoquinolines | |
| hydrastine hydrochloride, (s-(r*,s*))-isomer | [no description available] | low | 0 | 0 | isoquinolines | |
| oxyacanthine | [no description available] | low | 0 | 0 | bisbenzylisoquinoline alkaloid; isoquinolines; macrocycle; phenols; tertiary amino compound | |
| floxacillin | [no description available] | low | 0 | 0 | isoquinolines | |
| dioncophylline a | [no description available] | low | 0 | 0 | biaryl; isoquinoline alkaloid; isoquinolines; methoxynaphthalene; methylnaphthalenes; naphthalenes | antifungal agent; antimalarial; metabolite; molluscicide |
| dioncophylline c | [no description available] | low | 0 | 0 | aromatic ether; biaryl; isoquinoline alkaloid; isoquinolines; methoxynaphthalene; methylnaphthalenes; naphthols | antimalarial; antiplasmodial drug; metabolite |
| h 1152 | [no description available] | low | 0 | 0 | isoquinolines; N-sulfonyldiazepane | EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor |
| 9,10-dimethoxy-2,4,6,7-tetrahydro-[1,3]oxazino[4,3-a]isoquinoline-1-carbonitrile | [no description available] | low | 0 | 0 | isoquinolines | |
| hydrastine, (r-(r*,s*))-isomer | [no description available] | low | 0 | 0 | isoquinolines | |
| 6,7-dimethoxy-N-(4-methylphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-2-carboxamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 5-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(2-furanyl)-4-oxazolecarbonitrile | [no description available] | low | 0 | 0 | isoquinolines | |
| 1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-phenyl-1-butanone | [no description available] | low | 0 | 0 | isoquinolines | |
| methyl isoquinoline-3-carboxylate | [no description available] | low | 0 | 0 | isoquinolines | |
| 1-(3,4-dihydro-1H-isoquinolin-2-yl)-2-(2-fluorophenoxy)ethanone | [no description available] | low | 0 | 0 | isoquinolines | |
| 1-spiro[2,4-dihydroisoquinoline-3,1'-cyclohexane]thione | [no description available] | low | 0 | 0 | isoquinolines | |
| N-(4-methoxyphenyl)-3,4-dihydro-1H-isoquinoline-2-carbothioamide | [no description available] | low | 0 | 0 | isoquinolines | |
| N-(4-fluorophenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 3-amino-2-(4-methoxyphenyl)-7-nitro-1-oxo-4-isoquinolinecarbonitrile | [no description available] | low | 0 | 0 | isoquinolines | |
| 4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-(2,6-dimethylphenyl)benzamide | [no description available] | low | 0 | 0 | isoquinolines | |
| LSM-16526 | [no description available] | low | 0 | 0 | isoquinolines | |
| drotaverin | [no description available] | low | 0 | 0 | isoquinolines | |
| 5,5-diethyl-1-[oxo(1-piperidinyl)methyl]-6H-pyrrolo[2,1-a]isoquinoline-2,3-dione | [no description available] | low | 0 | 0 | isoquinolines | |
| N-(4-fluorophenyl)-2-(5-methoxy-1-oxo-2-isoquinolinyl)acetamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-[[1-oxo-2-[2-oxo-2-(1-piperidinyl)ethyl]-5-isoquinolinyl]oxy]acetic acid ethyl ester | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-[[2-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]acetic acid ethyl ester | [no description available] | low | 0 | 0 | isoquinolines | |
| 5-[[2-[(3-methylphenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxymethyl]-2-furancarboxylic acid methyl ester | [no description available] | low | 0 | 0 | isoquinolines | |
| 5-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethoxy]-2-[(3-methylphenyl)methyl]-3,4-dihydroisoquinolin-1-one | [no description available] | low | 0 | 0 | isoquinolines | |
| 4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-[4-(1-pyrrolidinylsulfonyl)phenyl]benzamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-N-[4-(1-piperidinylsulfonyl)phenyl]benzamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 1-(5-isoquinolinyl)-3-(2-phenylethyl)thiourea | [no description available] | low | 0 | 0 | isoquinolines | |
| 1-(4-ethoxyphenyl)-3-(5-isoquinolinyl)thiourea | [no description available] | low | 0 | 0 | isoquinolines | |
| 4-[[5-(difluoromethylthio)-4-methyl-1,2,4-triazol-3-yl]methoxy]-5-methylisoquinoline | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-[[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]thio]-3-ethyl-5,6-dimethyl-4-thieno[2,3-d]pyrimidinone | [no description available] | low | 0 | 0 | isoquinolines | |
| N-[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-2-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(2-methoxyethyl)acetamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-(Methylamino)-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione | [no description available] | low | 0 | 0 | isoquinolines | |
| 3-[3-(1,3-dioxo-2-benzo[de]isoquinolinyl)propylthio]propanoic acid | [no description available] | low | 0 | 0 | isoquinolines | |
| 4-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-(1,1-dioxo-3-thiolanyl)butanamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-[4-(3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyl]benzo[de]isoquinoline-1,3-dione | [no description available] | low | 0 | 0 | isoquinolines | |
| 4-bromobenzenesulfonic acid (1,3-dioxo-2-benzo[de]isoquinolinyl) ester | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-(3-hydroxyphenyl)-6-(1-piperidinyl)benzo[de]isoquinoline-1,3-dione | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-[3-(1H-1,2,4-triazol-5-ylthio)propyl]benzo[de]isoquinoline-1,3-dione | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-[2-[4-[2-hydroxy-3-(2-methylphenoxy)propyl]-1-piperazinyl]ethyl]benzo[de]isoquinoline-1,3-dione | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-benzoyl-N-(6-methoxy-3-pyridinyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide | [no description available] | low | 0 | 0 | isoquinolines | |
| mcn 5652 | [no description available] | low | 0 | 0 | isoquinolines | |
| 3-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-N-(6-methyl-2-pyridinyl)-1-oxo-3,4-dihydroisoquinoline-4-carboxamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 4-[(4-cyclohexyl-1-piperazinyl)-oxomethyl]-2-ethyl-6,7-dimethoxy-1-isoquinolinone | [no description available] | low | 0 | 0 | isoquinolines | |
| 1-[[1-(2-methoxyanilino)-4-isoquinolinyl]-oxomethyl]-4-piperidinecarboxamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 3,4-dihydro-1H-isoquinolin-2-yl-(1-ethylsulfonyl-4-piperidinyl)methanone | [no description available] | low | 0 | 0 | isoquinolines | |
| 1-cyclopentyl-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-5-oxo-3-pyrrolidinecarboxamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 3-(3,4-dimethoxyphenyl)-2-methyl-N-[2-(4-morpholinyl)ethyl]-1-oxo-3,4-dihydroisoquinoline-4-carboxamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 1-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-3-(4-ethylphenyl)urea | [no description available] | low | 0 | 0 | isoquinolines | |
| 6,7-dimethoxy-N-[(5-methyl-2-furanyl)methyl]-2-(2-methylpropyl)-1-oxo-4-isoquinolinecarboxamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 4-[[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholine | [no description available] | low | 0 | 0 | isoquinolines | |
| 5-[3,4-dihydro-1H-isoquinolin-2-yl(phenyl)methyl]-6-thiazolo[3,2-b][1,2,4]triazolol | [no description available] | low | 0 | 0 | isoquinolines | |
| 4-chloro-N-[1-(3,4-dihydro-1H-isoquinolin-2-yl)-2-methylpropan-2-yl]benzenesulfonamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 5-[2-[3-(4-fluorophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-oxoethoxy]-2-(phenylmethyl)-3,4-dihydroisoquinolin-1-one | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-[[2-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester | [no description available] | low | 0 | 0 | isoquinolines | |
| N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(4-fluorophenyl)-2-(2-methoxyethyl)-1-oxo-3,4-dihydroisoquinoline-4-carboxamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-[[2-[2-(4-methoxyanilino)-2-oxoethyl]-1-oxo-5-isoquinolinyl]oxy]propanoic acid ethyl ester | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-(4-chlorophenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid | [no description available] | low | 0 | 0 | isoquinolines | |
| 4-phenyl-1,2,3,4-tetrahydroisoquinoline | [no description available] | low | 0 | 0 | isoquinolines | |
| 6,7-dimethoxy-N-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 8-nitro-5-[3-(trifluoromethyl)-1-piperidinyl]isoquinoline | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-(3-methyl-1-oxo-2-isoquinolinyl)-N-(3,4,5-trimethoxyphenyl)acetamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 8-hydroxymanzamine a | [no description available] | low | 0 | 0 | alkaloid; beta-carbolines; isoquinolines | anti-HSV-2 agent; EC 2.7.11.26 (tau-protein kinase) inhibitor; metabolite |
| isoliensinine | [no description available] | low | 0 | 0 | isoquinolines | |
| mivacurium | [no description available] | low | 0 | 0 | isoquinolines | |
| bw b1090u | [no description available] | low | 0 | 0 | isoquinolines | |
| 3,4-dihydro-1H-isoquinolin-2-yl-(4-ethyl-5-thieno[3,2-b]pyrrolyl)methanone | [no description available] | low | 0 | 0 | isoquinolines | |
| papaveroline | [no description available] | low | 0 | 0 | isoquinolines | |
| norbinaltorphimine | [no description available] | low | 0 | 0 | isoquinolines | |
| naltrindole | [no description available] | low | 0 | 0 | isoquinolines | |
| manzamine a | [no description available] | low | 0 | 0 | alkaloid; beta-carbolines; isoquinolines | animal metabolite; anti-HSV-1 agent; antimalarial; antineoplastic agent; EC 2.7.11.26 (tau-protein kinase) inhibitor; marine metabolite |
| 2-(2-phenylethyl)benzo[de]isoquinoline-1,3-dione | [no description available] | low | 0 | 0 | isoquinolines | |
| ripasudil | [no description available] | low | 0 | 0 | isoquinolines | |
| ancistroealaine a | [no description available] | low | 0 | 0 | aromatic ether; biaryl; isoquinoline alkaloid; isoquinolines; methoxynaphthalene; methylnaphthalenes | antileishmanial agent; antiplasmodial drug; metabolite; trypanocidal drug |
| SIS3 free base | [no description available] | low | 0 | 0 | aromatic ether; enamide; isoquinolines; monocarboxylic acid amide; pyrrolopyridine; tertiary carboxamide | Smad3 inhibitor |
| fg-4592 | [no description available] | low | 0 | 0 | aromatic ether; isoquinolines; N-acylglycine | EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor; EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor |
| sar 1118 | [no description available] | low | 0 | 0 | 1-benzofurans; isoquinolines; L-phenylalanine derivative; N-acyl-L-alpha-amino acid; sulfone | anti-inflammatory drug; lymphocyte function-associated antigen-1 antagonist |
| 4-(4-chlorophenyl)sulfonyl-5-(3,4-dihydro-1H-isoquinolin-2-yl)-2-ethylsulfonylthiazole | [no description available] | low | 0 | 0 | isoquinolines | |
| bebeerine | [no description available] | low | 0 | 0 | bisbenzylisoquinoline alkaloid; isoquinolines | |
| (1S)-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-2-oxido-3,4-dihydro-1H-isoquinolin-2-ium-7-ol | [no description available] | low | 0 | 0 | isoquinolines; tertiary amine oxide | |
| dihydrotetrabenazine, (2alpha,3beta,11bbeta)-isomer | [no description available] | low | 0 | 0 | isoquinolines | |
| jorunnamycin a | [no description available] | low | 0 | 0 | isoquinolines | |
| 1-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-3-(4-nitrophenyl)urea | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-(1,3-benzodioxol-5-ylmethyl)-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline | [no description available] | low | 0 | 0 | isoquinolines | |
| N-(3-nitrophenyl)-3,4-dihydro-1H-isoquinoline-2-carboxamide | [no description available] | low | 0 | 0 | isoquinolines | |
| 2-(5-butoxy-1-oxo-2-isoquinolinyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide | [no description available] | low | 0 | 0 | isoquinolines | |
| almorexant | [no description available] | low | 0 | 0 | isoquinolines | |
| ipi-145 | [no description available] | low | 0 | 0 | isoquinolines | |
| nbi 31772 | [no description available] | low | 0 | 0 | aromatic ketone; benzenediols; hydroxy monocarboxylic acid; isoquinolines; tetrol | insulin-like growth factor-binding protein inhibitor |
| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|---|---|---|---|
| Germinoblastoma | 0 | low | 1 | 0 |
| Lymphoma | 0 | low | 1 | 0 |
| Lymphoma, Malignant | 0 | low | 1 | 0 |
| Reticulolymphosarcoma | 0 | low | 1 | 0 |
| Sarcoma, Germinoblastic | 0 | low | 1 | 0 |
| Article | Year |
|---|---|
| Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses. Cancer immunology, immunotherapy : CII, Volume: 49, Issue: 4-5 | 2000 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |