Compounds > butantrone
Page last updated: 2024-11-06

butantrone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID53271
CHEMBL ID130968
SCHEMBL ID2109872
MeSH IDM0115748

Synonyms (25)

Synonym
butantronum [latin]
dithranol, 10-butyryl-
ccris 2041
9(10h)-anthracenone, 1,8-dihydroxy-10-(1-oxobutyl)-
10-butyryl-1,8-dihydroxyanthrone
butantrone
butantrone [inn]
10-butyryl dithranol
brn 4197920
butantrona [spanish]
bdbm50043351
10-butyryl-1,8-dihydroxy-10h-anthracen-9-one(butantrone)
CHEMBL130968 ,
10-butanoyl-1,8-dihydroxy-10h-anthracen-9-one
unii-9p148iba8m
butantrona
9p148iba8m ,
75464-11-8
butantronum
butantrone [who-dd]
DTXSID10226395
AHZXFRRDQXXPJD-UHFFFAOYSA-N
1,8-dihydroxy-10-butyryl-9-anthrone
SCHEMBL2109872
Q27272844

Research Excerpts

Effects

ExcerptReferenceRelevance
"Butantrone has an antipsoriatic activity almost equal to that of dithranol."( Comparison of dithranol and butantrone in short contact therapy of psoriasis.
Göransson, A, 1987)		1.29
"Butantrone has an antipsoriatic activity almost equal to that of dithranol."( Comparison of dithranol and butantrone in short contact therapy of psoriasis.
Göransson, A, 1987)		1.29

Actions

ExcerptReferenceRelevance
"Butantrone did not cause significant increases in gaps or breaks."( Toxicological studies with dithranol and its 10-acyl analogues.
Kirkland, D; Männistö, PT; Tikkanen, L; Viluksela, M, 1986)		0.99

Dosage Studied

ExcerptRelevanceReference
" In metaphase analysis of in vitro treated human lymphocytes, dithranol, 10-acetyl dithranol and 10-propionyl dithranol produced significant increases in the number of chromosome and chromatid gaps but without a clear dose-response relationship, and without inducing significant breaks."( Toxicological studies with dithranol and its 10-acyl analogues.
Kirkland, D; Männistö, PT; Tikkanen, L; Viluksela, M, 1986)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
5-lipoxygenase Bos taurus (cattle)IC50 (µMol)18.50000.18001.75824.0000AID54297; AID6882
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID228687Deoxyribose-damaging property as a measure of hydroxyl-radical formation (uM test compound)1993Journal of medicinal chemistry, Dec-10, Volume: 36, Issue:25
Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase.
AID25770Reducing activity against 2,2-diphenyl-1-picrylhydrazyl1993Journal of medicinal chemistry, Dec-10, Volume: 36, Issue:25
Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase.
AID6882Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).1993Journal of medicinal chemistry, Dec-10, Volume: 36, Issue:25
Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase.
AID54297Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomes1993Journal of medicinal chemistry, Dec-10, Volume: 36, Issue:25
Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-199017 (80.95)18.7374
1990's3 (14.29)18.2507
2000's0 (0.00)29.6817
2010's1 (4.76)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.75 (24.57)
Research Supply Index3.26 (2.92)
Research Growth Index4.01 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials4 (19.05%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (80.95%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzyl alcohol
Benzyl Alcohol: A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.. hydroxytoluene : Any member of the class of toluenes carrying one or more hydroxy substituents.. benzyl alcohol : An aromatic alcohol that consists of benzene bearing a single hydroxymethyl substituent.. aromatic alcohol : Any alcohol in which the alcoholic hydroxy group is attached to a carbon which is itself bonded to an aromatic ring.. aromatic primary alcohol : Any primary alcohol in which the alcoholic hydroxy group is attached to a carbon which is itself bonded to an aromatic ring.		2.0510benzyl alcoholsantioxidant;
fragrance;
metabolite;
solvent
anthralin
Anthralin: An anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.. anthralin : An anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9.		6.93214anthracenesantipsoriatic
masoprocol
nordihydroguaretic acid: antioxidant compound found in the creosote bush (Larrea tridentata)		1.9810catechols;
lignan;
tetrol		antioxidant;
ferroptosis inhibitor;
geroprotector;
plant metabolite
9,10-dimethyl-1,2-benzanthracene
9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.		1.9610ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
bromodeoxyuridine
Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.		1.9710pyrimidine 2'-deoxyribonucleosideantimetabolite;
antineoplastic agent
furaldehyde
Furaldehyde: A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.. furfural : An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.		2.0510aldehyde;
furans		Maillard reaction product;
metabolite
triacetyldithranol
[no description available]		1.9810
lonapalene
RS 43179: used in treatment of psoriasis		1.9810naphthalenes;
organochlorine compound
cd 3 color developer
CD 3 color developer: used in film laboratories; causes contact dermatitis & lichenoid reactions; RN given refers to parent cpd		1.9710
5-hydroxymethylfurfural
5-hydroxymethylfurfural: has antisickling activity; HMF is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo. 5-hydroxymethylfurfural : A member of the class of furans that is furan which is substituted at positions 2 and 5 by formyl and hydroxymethyl substituents, respectively. Virtually absent from fresh foods, it is naturally generated in sugar-containing foods during storage, and especially by drying or cooking. It is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo.		2.0510arenecarbaldehyde;
furans;
primary alcohol		indicator;
Maillard reaction product
ConditionIndicatedRelationship StrengthStudiesTrials
Erythema
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.		02.8840
Palmoplantaris Pustulosis
[description not available]		06.1494
Psoriasis
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.		06.1494
Dermatitis Medicamentosa
[description not available]		04.0431
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.3720
Experimental Leukemia
[description not available]		01.9610
Cancer of Skin
[description not available]		02.3720
Mast-Cell Sarcoma
A unifocal malignant tumor that consists of atypical pathological MAST CELLS without systemic involvement. It causes local destructive growth in organs other than in skin or bone marrow.		01.9610
Experimental Mammary Neoplasms
[description not available]		01.9610
Skin Neoplasms
Tumors or cancer of the SKIN.		02.3720
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		01.9810
Contact Dermatitis
[description not available]		02.3720
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		01.9710
Dermatitis, Contact
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.		02.3720
Hyperplasia
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.		01.9610
Anasarca
[description not available]		01.9710
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		01.9710
Experimental Neoplasms
[description not available]		01.9610
Papilloma, Squamous Cell
[description not available]		01.9610
Papilloma
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)		01.9610