Propioveratrone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Propioveratrone is a synthetic compound that has been studied for its potential therapeutic properties. It is a derivative of veratramine, a natural alkaloid found in the Veratrum plants. Propioveratrone has shown promising results in preclinical studies, demonstrating anti-inflammatory, analgesic, and neuroprotective effects. Its synthesis involves a multi-step process starting from veratramine. The compound's effects are attributed to its ability to modulate various signaling pathways, including the inflammatory cascade and the nervous system. The research on propioveratrone is driven by its potential to develop novel treatments for conditions like pain, inflammation, and neurodegenerative diseases. Further investigations are ongoing to understand its precise mechanisms of action and its safety profile for clinical applications.'

Cross-References

ID Source	ID
PubMed CID	15781
CHEMBL ID	479685
CHEBI ID	167438
SCHEMBL ID	515746

Synonyms (38)

Synonym
nsc 16954
CHEBI:167438
1-(3,4-dimethoxy-phenyl)-propan-1-one
smr000387103
MLS001048910
1-propanone, 1-(3,4-dimethoxyphenyl)-
ai3-23454
nsc16954
3,4-dimethoxyphenyl ethyl ketone
1-(3,4-dimethoxyphenyl)-1-propanone
1835-04-7
3,4-dimethoxypropiophenone
3',4'-dimethoxypropiophenone
nsc-16954
propioveratrone
propiophenone, 3',4'-dimethoxy-
GHL.PD_MITSCHER_LEG0.580
STK043726
1-(3,4-dimethoxyphenyl)propan-1-one
AKOS000115379
CHEMBL479685
NCGC00246237-01
EN300-01082
BBL009808
1-(3,4-dimethoxyphenyl)-propan-1-one
HMS2268J04
3',4'-dimethoxy-1-phenylpropiophenone
FT-0614354
AM20030211
SCHEMBL515746
Z57952774
propan-1-one, 1-(3,4-dimethoxyphenyl)-
DTXSID60171427
mfcd00482089
1-(3,4-dimethoxy-phenyl)-propan-1-one, aldrichcpr
NS-01887
Y14672
CS-0152658

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
aromatic ketone	A ketone in which the carbonyl group is attached to an aromatic ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	0.7079	0.0447	17.8581	100.0000	AID485294
glp-1 receptor, partial	Homo sapiens (human)	Potency	7.9433	0.0184	6.8060	14.1254	AID624417
TDP1 protein	Homo sapiens (human)	Potency	2.9093	0.0008	11.3822	44.6684	AID686978
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (29)

Assay ID	Title	Year	Journal	Article
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID376042	Antifungal activity against Trichophyton mentagrophytes ATCC 9972 up to 50 ug/mL by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376049	Antifungal activity against Candida albicans ATCC 10231 by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376052	Antifungal activity against Aspergillus flavus ATCC 9170 by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376043	Antifungal activity against Trichophyton rubrum C 113 up to 50 ug/mL by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376054	Antifungal activity against Aspergillus niger ATCC 9029 by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376055	Antifungal activity against Microsporum canis C 112 by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376051	Antifungal activity against Cryptococcus neoformans ATCC 32264 by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376044	Antifungal activity against Epidermophyton floccosum C 114 up to 50 ug/mL by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376040	Antifungal activity against Microsporum canis C 112 up to 50 ug/mL by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376053	Antifungal activity against Aspergillus fumigatus ATCC 26934 by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376041	Antifungal activity against Microsporum gypseum C 115 up to 50 ug/mL by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376045	Antifungal activity against Microsporum gypseum C 115 by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376046	Antifungal activity against Trichophyton mentagrophytes ATCC by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376050	Antifungal activity against Saccharomyces cerevisiae ATCC 9763 by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376048	Antifungal activity against Epidermophyton floccosum C 114 by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
AID376047	Antifungal activity against Trichophyton rubrum C 113 by agar dilution method	1999	Journal of natural products, Oct, Volume: 62, Issue:10	In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (16.67)	18.2507
2000's	1 (16.67)	29.6817
2010's	3 (50.00)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.87 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.82 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
naphthalene [no description available]	2	1	naphthalenes; ortho-fused bicyclic arene	apoptosis inhibitor; carcinogenic agent; environmental contaminant; mouse metabolite; plant metabolite; volatile oil component
phenanthrene phenanthrene : A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.'	2	1	ortho-fused polycyclic arene; ortho-fused tricyclic hydrocarbon; phenanthrenes	environmental contaminant; mouse metabolite
ketoconazole 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.	2	1	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
myristicin myristicin: asaricin is an isomer; structure; a methylene dioxy version of elemicin;	2	1	organic molecular entity	metabolite
methyleugenol methyleugenol: structure	2	1	phenylpropanoid
elemicin [no description available]	2	1	olefinic compound
isoeugenol [no description available]	2	1	isoeugenol
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	2	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite

Condition	Indicated	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	0	2.05	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.05	1	0

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