Page last updated: 2024-12-07

uzarigenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Uzarigenin is a steroidal sapogenin isolated from the roots of *Phytolacca dodecandra*, a plant native to Africa. It has shown significant anti-inflammatory and anti-tumor activities in various studies. Uzarigenin's unique structure, with a spiroketal ring system, makes it a promising candidate for the development of new drugs. Researchers are studying its mechanisms of action and its potential applications in treating various diseases, including cancer and inflammatory disorders.'
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Cross-References

ID SourceID
PubMed CID92760
CHEMBL ID109863
SCHEMBL ID1152953
MeSH IDM0006382

Synonyms (33)

Synonym
uzarigenin
nsc 119993
einecs 207-373-0
3beta,14-dihydroxy-5alpha-card-20(22)-enolide
3-beta-14-beta-5-allo-cardenolid [german]
card-20(22)-enolide, 3,14-dihydroxy-, (3beta,5alpha)-
5alpha-card-20(22)-enolide, 3beta,14-dihydroxy-
brn 0095446
3-beta,14-dihydroxy-5-alpha-card-20(22)-enolide
5-alpha-card-20(22)-enolide, 3-beta,14-dihydroxy-
CHEMBL109863
3-beta-14-beta-5-allo-cardenolid
unii-k9zr7li283
k9zr7li283 ,
card-20(22)-enolide, 3,14-dihydroxy-, (3.beta.,5.alpha.)-
uzarigenin [mi]
urarigenin
odorigeni
(3.beta.,5.alpha.)-3,14-dihydroxycard-20(22)-enolide
odorigenin
SCHEMBL1152953
3,14-dihydroxycard-20(22)-enolide #
XZTUSOXSLKTKJQ-CIXPXFMPSA-N
5.alpha.-card-20(22)-enolide, 3.beta.,14-dihydroxy-
3-.beta.-14-.beta.-5-allo-cardenolid
ncgc00384854-01_c23h34o4_card-20(22)-enolide, 3,14-dihydroxy-, (3beta,5alpha)-
NCGC00384854-01
uzarigenin (odorigenin)
FS-9903
DTXSID901017013
nsc 119993; nsc 277290; odorigeni; urarigenin
Q27282143
AKOS040762476

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1575481Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa.
AID1674387Cytotoxicity against human Hs-578T cells assessed as reduction in cell viability after 48 hrs by SRB assay
AID1674396Selectivity index, ratio of IC50 for human MDA-MB-231 cells to IC50 for human BT-549 cells
AID1674386Cytotoxicity against human BT-549 cells assessed as reduction in cell viability after 48 hrs by SRB assay
AID1674397Inhibition of porcine cerebral cortex Na+/K+-ATPase after 15 mins by ADP-Glo reagent based assay
AID1575479Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa.
AID1575482Antiproliferative activity against human Calu1 cells after 72 hrs by MTT assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa.
AID1575483Antiproliferative activity against human U251MG cells after 72 hrs by MTT assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa.
AID1575480Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa.
AID1674393Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by SRB assay
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's3 (60.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.30

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.30 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.30)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]