Compounds > 8-hydroxymianserin
Page last updated: 2024-09-26

8-hydroxymianserin

Description

8-hydroxymianserin: metabolite of mianserin; RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID162817
SCHEMBL ID2739028
MeSH IDM0093601

Synonyms (15)

Synonym
8-hydroxymianserin
57257-81-5
2h-dibenzo(c,f)pyrazino(1,2-a)azepin-8-ol, 1,2,3,4,10,14b-hexahydro-2-methyl-
FT-0669860
unii-cd0r9qb6hd
cd0r9qb6hd ,
8-hydroxy mianserin
SCHEMBL2739028
8-hydroxy ms
dibenzo(c,f)pyrazino(1,2-a)azepin-8-ol, 1,2,3,4,10,14b-hexahydro-2-methyl-
5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaen-17-ol
DTXSID30972746
2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepin-8-ol
Q27275402
5-methyl-2,5-diazatetracyclo[13.4.0.0?,?.0?,??]nonadeca-1(15),8,10,12,16,18-hexaen-17-ol

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (57.14)18.7374
1990's3 (42.86)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
mianserin[no description available]medium80dibenzoazepineadrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
H1-receptor antagonist;
histamine agonist;
sedative;
serotonergic antagonist
desmethylmianserin[no description available]medium30dibenzooxazepine
indomethacin[no description available]medium10aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
clonidine[no description available]medium10clonidine;
imidazoline
methoxyhydroxyphenylglycol[no description available]medium10methoxybenzenes;
phenols
ConditionIndicatedRelationship StrengthStudiesTrials
Depression0low10
Muscle Contraction0low10

Research Highlights

Long-term Use (1)

ArticleYear
Adrenoreceptor interactions of the enantiomers and metabolites of mianserin: are they responsible for the antidepressant effect?
Acta psychiatrica Scandinavica. Supplementum, Volume: 320		1985
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

ArticleYear
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]