8-hydroxymianserin has been researched along with mianserin in 7 studies
| Studies (8-hydroxymianserin) | Trials (8-hydroxymianserin) | Recent Studies (post-2010) (8-hydroxymianserin) | Studies (mianserin) | Trials (mianserin) | Recent Studies (post-2010) (mianserin) |
|---|---|---|---|---|---|
| 8 | 0 | 0 | 2,624 | 539 | 488 |
| Protein | Taxonomy | 8-hydroxymianserin (IC50) | mianserin (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | 1.4125 | |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.0012 | |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | 1.4125 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.163 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 1.078 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 2.066 | |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.3981 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 1.9 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.32 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.0213 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 1.423 | |
| D(2) dopamine receptor | Homo sapiens (human) | 7.0795 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.38 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.026 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0661 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.872 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.21 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 1.405 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 0.543 | |
| D(4) dopamine receptor | Homo sapiens (human) | 3.3113 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.21 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.21 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.38 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.163 | |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | 1.4125 | |
| Histamine H2 receptor | Homo sapiens (human) | 1.008 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.083 | |
| Endothelin-1 receptor | Homo sapiens (human) | 0.1148 | |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | 0.3802 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.011 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.0043 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.872 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 2.068 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 2.9 | |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | 0.1148 | |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | 0.4074 | |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.21 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.0024 | |
| D(3) dopamine receptor | Homo sapiens (human) | 3.8905 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.0073 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.19 | |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | 1.4125 | |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | 0.88 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 0.085 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 3.5481 | |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | 1.4125 | |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | 1.4125 | |
| 5-hydroxytryptamine receptor 3B | Mus musculus (house mouse) | 1.4125 | |
| Transporter | Rattus norvegicus (Norway rat) | 0.022 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hand, TH; Marek, GJ; Seiden, LS | 1 |
| Roeder, T | 1 |
| Doggrell, SA | 1 |
| Pinder, RM | 1 |
| Leonard, BE; O'Connor, WT | 1 |
| Cooper, TB; Quitkin, FM; Stewart, JW; Suckow, RF | 1 |
| Baettig, D; Baumann, P; Campus-Souche, D; Eap, CB; Monney, C; Powell, K; Taeschner, W | 1 |
1 review(s) available for 8-hydroxymianserin and mianserin
| Article | Year |
|---|---|
Adrenoreceptor interactions of the enantiomers and metabolites of mianserin: are they responsible for the antidepressant effect?
Topics: Animals; Antidepressive Agents; Binding, Competitive; Biotransformation; Cerebral Cortex; Clonidine; Dibenzazepines; Isomerism; Mianserin; Norepinephrine; Radioligand Assay; Rats; Receptors, Adrenergic, alpha; Serotonin Antagonists; Synaptic Transmission | 1985 |
6 other study(ies) available for 8-hydroxymianserin and mianserin
| Article | Year |
|---|---|
Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Conditioning, Operant; Depression; Male; Mianserin; Rats; Rats, Inbred Strains; Receptors, Serotonin; Stereoisomerism | 1991 |
High-affinity antagonists of the locust neuronal octopamine receptor.
Topics: Animals; Dibenzazepines; Female; Ganglia; Grasshoppers; Male; Mianserin; Nerve Tissue; Radioligand Assay; Receptors, Adrenergic; Receptors, Biogenic Amine | 1990 |
Postjunctional effects of mianserin and its metabolites on the rat isolated anococcygeus muscle.
Topics: Animals; Dibenzazepines; Dose-Response Relationship, Drug; In Vitro Techniques; Indomethacin; Male; Methacholine Compounds; Mianserin; Muscle Contraction; Rats; Rats, Inbred Strains | 1985 |
The effect of chronically administered mianserin, 8-hydroxymianserin and desmethylmianserin on the 'open field' behaviour and brain noradrenaline metabolism in the olfactory bulbectomized rat.
Topics: Animals; Behavior, Animal; Brain; Male; Methoxyhydroxyphenylglycol; Mianserin; Norepinephrine; Olfactory Bulb; Rats; Rats, Inbred Strains | 1987 |
Determination of mianserin and metabolites in plasma by liquid chromatography with electrochemical detection.
Topics: Biotransformation; Chromatography, Liquid; Dibenzazepines; Electrochemistry; Humans; Mianserin; Oxidation-Reduction | 1982 |
Determination of the enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin in the plasma and urine of mianserin-treated patients.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Female; Genotype; Humans; Male; Mianserin; Middle Aged; Polymerase Chain Reaction; Stereoisomerism | 1994 |