Page last updated: 2024-12-07
5,6-dicarboxyfluorescein
5,6-dicarboxyfluorescein is a fluorescent dye that has been widely used in various applications, including cell imaging, biosensing, and drug delivery. It is a derivative of fluorescein, with two carboxylic acid groups attached at the 5 and 6 positions. The presence of these carboxylic acid groups enhances its water solubility and allows for conjugation with other molecules. 5,6-dicarboxyfluorescein exhibits strong fluorescence in the green region of the spectrum when excited with blue light. Its fluorescence intensity is highly sensitive to changes in pH, making it a valuable tool for studying intracellular pH gradients. Furthermore, 5,6-dicarboxyfluorescein has been used to develop fluorescent probes for detecting various analytes, including metal ions, enzymes, and small molecules. Its ability to interact with specific biomolecules has led to its use in drug delivery systems, where it can be used to target specific cells or tissues.'
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Cross-References
| ID Source | ID |
|---|
| PubMed CID | 115343 |
| SCHEMBL ID | 7955927 |
| MeSH ID | M0122105 |
Synonyms (6)
| Synonym |
|---|
| 90829-94-0 |
| 5,6-dicarboxyfluorescein |
| spiro(isobenzofuran-1(3h),9'-(9h)xanthene)-5,6-dicarboxylic acid, 3',6'-dihydroxy-3-oxo- |
| 3',6'-dihydroxy-3-oxospiro(isobenzofuran-1(3h),9'-(9h)xanthene)-5,6-dicarboxylic acid |
| SCHEMBL7955927 |
| DTXSID90238294 |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.94
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.94 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.73 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |