Compounds > 5,6-dicarboxyfluorescein
Page last updated: 2024-11-07

5,6-dicarboxyfluorescein

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

5,6-dicarboxyfluorescein is a fluorescent dye that has been widely used in various applications, including cell imaging, biosensing, and drug delivery. It is a derivative of fluorescein, with two carboxylic acid groups attached at the 5 and 6 positions. The presence of these carboxylic acid groups enhances its water solubility and allows for conjugation with other molecules. 5,6-dicarboxyfluorescein exhibits strong fluorescence in the green region of the spectrum when excited with blue light. Its fluorescence intensity is highly sensitive to changes in pH, making it a valuable tool for studying intracellular pH gradients. Furthermore, 5,6-dicarboxyfluorescein has been used to develop fluorescent probes for detecting various analytes, including metal ions, enzymes, and small molecules. Its ability to interact with specific biomolecules has led to its use in drug delivery systems, where it can be used to target specific cells or tissues.'
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Cross-References

ID SourceID
PubMed CID115343
SCHEMBL ID7955927
MeSH IDM0122105

Synonyms (6)

Synonym
90829-94-0
5,6-dicarboxyfluorescein
spiro(isobenzofuran-1(3h),9'-(9h)xanthene)-5,6-dicarboxylic acid, 3',6'-dihydroxy-3-oxo-
3',6'-dihydroxy-3-oxospiro(isobenzofuran-1(3h),9'-(9h)xanthene)-5,6-dicarboxylic acid
SCHEMBL7955927
DTXSID90238294
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.94 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.94)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
quinacrine
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.. quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.		1.9610acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound		antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		3.1550
p-dimethylaminoazobenzene
p-Dimethylaminoazobenzene: A reagent used mainly to induce experimental liver cancer. According to the Fourth Annual Report on Carcinogens (NTP 85-002, p. 89) published in 1985, this compound may reasonably be anticipated to be a carcinogen. (Merck, 11th ed)		2.6920azobenzenes
aminacrine
Aminacrine: A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.. 9-aminoacridine : An aminoacridine that is acridine in which the hydrogen at position 9 is replaced by an amino group. A fluorescent dyd and topical antiseptic agent, it is used (usually as the hydrochloride salt) in eye drops for the treatment of superficial eye infections.		1.9610aminoacridines;
primary amino compound		acid-base indicator;
antiinfective agent;
antiseptic drug;
fluorescent dye;
MALDI matrix material;
mutagen
acridines
Acridines: Compounds that include the structure of acridine.. acridine : A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom.		1.9610acridines;
mancude organic heterotricyclic parent;
polycyclic heteroarene		genotoxin
4-(4-dimethylaminophenylazo)benzoic acid
4-(4-dimethylaminophenylazo)benzoic acid: structure given in first source		2.6920
fluorexon
fluorexon: structure		2.0510xanthene dyefluorochrome
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		2.05101,2-diacyl-sn-glycero-3-phosphocholine
ConditionIndicatedRelationship StrengthStudiesTrials
Allergic Reaction
[description not available]		02.1110
Hypersensitivity
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.		02.1110