Page last updated: 2024-11-12

3,6'-dithiothalidomide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,6'-dithiothalidomide: inhibits TNF-alpha synthesis [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10017108
CHEMBL ID149057
SCHEMBL ID2174826
MeSH IDM0562328

Synonyms (7)

Synonym
CHEMBL149057
SCHEMBL2174826
3,6'-dithiothalidomide
2-(2-oxo-6-sulfanylidenepiperidin-3-yl)-3-sulfanylideneisoindol-1-one
2-(2-oxo-6-sulfanylidenepiperidin-3-yl)-3-sulfanylidene-2,3-dihydro-1h-isoindol-1-one
628337-09-7
2-(6-mercapto-2-oxo-2,3,4,5-tetrahydropyridin-3-yl)-3-thioxoisoindolin-1-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID152948Compound was tested for the inhibition of LPS-induced TNF-alpha production in human peripheral blood mononuclear cells (PBMC) at 30 uM2003Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity.
AID152809Compound was tested for the cell viability in human peripheral blood mononuclear cells (PBMC) at 30 uM2003Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity.
AID152808Compound was tested for the cell viability in human peripheral blood mononuclear cells (PBMC) at 3.0 uM2003Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity.
AID152807Compound was tested for the cell viability in human peripheral blood mononuclear cells (PBMC) at 0.3 uM2003Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity.
AID152933Compound was tested for the inhibition of LPS-induced TNF-alpha production in human peripheral blood mononuclear cells (PBMC)2003Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (8.33)29.6817
2010's11 (91.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.21 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.77 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.21)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]