Compounds > 3-(trimethylsilyl)propionic acid
Page last updated: 2024-11-06

3-(trimethylsilyl)propionic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-(trimethylsilyl)propionic acid is a versatile organosilicon compound used as a reagent and intermediate in organic synthesis. It is a colorless liquid with a pungent odor and is soluble in organic solvents. It is typically synthesized by the reaction of trimethylsilyl chloride with propionic acid in the presence of a base. The compound is known for its ability to act as a protecting group for carboxylic acids, preventing their reactivity in various chemical transformations. It is also used as a precursor to various organosilicon compounds, such as silanes and siloxanes. The compound has been investigated for its potential applications in areas like polymer chemistry, material science, and pharmaceuticals. The presence of the trimethylsilyl group imparts unique properties to the compound, such as hydrophobicity and thermal stability. Its ability to form stable derivatives makes it a valuable tool for protecting sensitive functional groups and enabling efficient multi-step reactions. The compound is studied due to its potential in drug discovery and development, as well as its use as a building block for various organic and inorganic materials.'

3-(trimethylsilyl)propionic acid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

3-(trimethylsilyl)propionic acid : An organosilicon compound that is propionic acid substituted at position 3 by a trimethylsilyl group. It is used as internal reference in the NMR spectrum nuclear magnetic resonance for aqueous solvents (e.g. D2O). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID79764
CHEBI ID141028
CHEBI ID85487
SCHEMBL ID445043
MeSH IDM0514326

Synonyms (36)

Synonym
unii-x8h75z8p93
x8h75z8p93 ,
NCIOPEN2_001431
einecs 227-145-4
nsc 93018
2-silapentan-5-oic acid, 2,2-dimethyl-
5683-30-7
propionic acid, 3-(trimethylsilyl)-
propanoic acid, 3-(trimethylsilyl)-
nsc93018
2-silapentan-5-oic acid,2-dimethyl-
3-(trimethylsilyl)propionic acid
nsc-93018
3-trimethylsilylpropionic acid
inchi=1/c6h14o2si/c1-9(2,3)5-4-6(7)8/h4-5h2,1-3h3,(h,7,8
3-(trimethylsilyl)propanoic acid
d4-trimethyl silyl propionic acid
CHEBI:141028
3-trimethylsilylpropanoic acid
AKOS006230457
SCHEMBL445043
3-(trimethylsilyl)propionicacid
tmsch2ch2co2h
4,4-dimethyl-4-silapentanoic acid
DTXSID7063978
3-(trimethylsilyl)propanoic acid #
tmsp
CHEBI:85487
3-(trimethylsilyl) propionic acid
mfcd00002761
FT-0764233
Q408143
3-(trimethylsilyl)propanoicacid
trimethylsilylpropanoic acid
3-(trimethylsilanyl)propionic acid
F76046
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
NMR chemical shift reference compoundAny compound that produces a peak used to reference an NMR spectrum during data pre-processing.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
organosilicon compoundAn organosilicon compound is a compound containing at least one carbon-silicon bond.
monocarboxylic acidAn oxoacid containing a single carboxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.25 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index30.00 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (31.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
alpha-hydroxyglutarate
2-hydroxyglutarate : A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.. 2-hydroxyglutaric acid : A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.		2.17102-hydroxydicarboxylic acid;
dicarboxylic fatty acid		metabolite;
mouse metabolite
formic acid
formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.		2.0510monocarboxylic acidantibacterial agent;
astringent;
metabolite;
protic solvent;
solvent
propionic acid
propionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.		7.0310saturated fatty acid;
short-chain fatty acid		antifungal drug
chloroform
Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.		2.1710chloromethanes;
one-carbon compound		carcinogenic agent;
central nervous system drug;
inhalation anaesthetic;
non-polar solvent;
refrigerant
perchloric acid
[no description available]		2.1710chlorine oxoacid
deuterium oxide
Deuterium Oxide: The isotopic compound of hydrogen of mass 2 (deuterium) with oxygen. (From Grant & Hackh's Chemical Dictionary, 5th ed) It is used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.		2.1710deuterated compound;
water		NMR solvent
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms, Brain
[description not available]		02.1710
Glial Cell Tumors
[description not available]		02.1710
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		02.1710
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)		02.1710
Astheno Teratozoospermia
[description not available]		02.0610
Sterility, Male
[description not available]		02.0610
Hypospermatogenesis
[description not available]		02.0610
Infertility, Male
The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.		02.0610