Page last updated: 2024-12-07
1-naphthylglucoside
Description
## 1-Naphthylglucoside: A Key to Understanding Enzyme Activity
**1-Naphthylglucoside** is a synthetic compound, specifically a **glucoside**, that is used in research as a **substrate** for certain enzymes, particularly **glucosidases**.
**Here's why it's important:**
* **Substrate for Enzyme Assays:** 1-Naphthylglucoside is specifically designed to be cleaved by glucosidases. This means it can be used in **enzyme assays** to measure the activity of these enzymes. When the enzyme breaks down the glucoside, it releases **1-naphthol**, a molecule that can be easily detected and quantified. This allows researchers to understand how much enzyme activity is present in a sample.
* **Understanding Enzyme Specificity:** Glucosidases are a family of enzymes that break down different types of glycosidic bonds. 1-Naphthylglucoside can be used to study the **substrate specificity** of different glucosidases, allowing scientists to understand which specific types of glycosidic bonds they can break. This knowledge is crucial for understanding their biological roles.
* **Research into Diseases:** 1-Naphthylglucoside is also used in research related to diseases associated with glucosidase dysfunction. For example, **Gaucher disease** is a genetic disorder caused by a deficiency in the enzyme **glucocerebrosidase**. Researchers use 1-Naphthylglucoside to measure glucocerebrosidase activity in patients and understand the disease progression and effectiveness of treatments.
* **Drug Development:** Understanding the activity of glucosidases is critical for the development of new drugs targeting these enzymes. 1-Naphthylglucoside helps researchers screen potential drug candidates that might inhibit or enhance glucosidase activity.
**In summary, 1-Naphthylglucoside is a valuable tool for researchers studying glucosidases, enabling them to understand enzyme activity, substrate specificity, and potential applications for treating diseases and developing new drugs.**
1-naphthylglucoside: used in analysis of UDPglucosyltransferase [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 88316 |
| MeSH ID | M0112924 |
Synonyms (5)
| Synonym |
|---|
| 1-naphthylglucoside |
| (2s,4r,6r)-2-(hydroxymethyl)-6-naphthalen-1-yloxyoxane-3,4,5-triol |
| beta-naphthyl-beta-d-glucopyranoside |
| einecs 243-434-8 |
| 1-naphthalenylglucopyranoside |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.51
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.51 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.31 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |