Page last updated: 2024-12-08

1,3-cyclooctadiene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 1,3-Cyclooctadiene: A Versatile Building Block

**1,3-Cyclooctadiene** (also known as COD) is a cyclic organic compound with the molecular formula C8H12. It is a colorless liquid at room temperature with a characteristic sweet odor.

**Key Features:**

* **Structure:** COD has a unique eight-membered ring containing two double bonds at positions 1 and 3.
* **Reactivity:** The double bonds in COD make it susceptible to a variety of reactions, including:
* **Metathesis reactions:** COD can be used to form new carbon-carbon bonds via ring-opening metathesis polymerization (ROMP).
* **Hydrogenation:** It can be readily hydrogenated to form cyclooctane.
* **Cycloaddition reactions:** COD can participate in Diels-Alder reactions and other cycloaddition reactions.
* **Complexation with metals:** The double bonds in COD can coordinate with metal ions, forming complexes.

**Importance in Research:**

COD's versatile reactivity makes it a valuable reagent in various fields, particularly in:

* **Organic synthesis:** It acts as a precursor for synthesizing various organic compounds, including pharmaceuticals and polymers.
* **Catalysis:** COD is used as a ligand in metal-catalyzed reactions, such as olefin metathesis and hydrogenation.
* **Materials science:** COD can be polymerized to form polymers with interesting properties, like high tensile strength and flexibility.
* **Coordination chemistry:** Its ability to form metal complexes allows for the study of coordination chemistry and its applications in catalysis and sensing.

**Specific Examples:**

* **ROMP:** COD is used to synthesize polymers like polyoctenamer, a highly elastic and durable material with various applications.
* **Nickel catalysts:** COD is used as a ligand in nickel-catalyzed cross-coupling reactions, important for synthesizing complex organic molecules.
* **Coordination chemistry:** COD complexes with metal ions like rhodium and palladium are crucial for catalytic transformations like hydrogenation and carbon-carbon bond formation.

**In summary, 1,3-cyclooctadiene is a versatile compound with a unique structure and reactivity that makes it an important tool in various research areas, particularly in organic synthesis, catalysis, and materials science.** Its application in developing new catalysts, polymers, and other materials continues to expand as researchers explore its potential.

Cross-References

ID SourceID
PubMed CID299882
MeSH IDM0367701

Synonyms (36)

Synonym
nsc 105773
nsc 72422
ai3-26696
einecs 216-929-1
1,3-cyclooctadiene, (z,z)-
cis,cis-1,3-cyclooctadiene
nsc72422
nsc-72422
1,3-cyclooctadiene ,
nsc-105773
1700-10-3
nsc105773
(1z,3z)-cycloocta-1,3-diene
inchi=1/c8h12/c1-2-4-6-8-7-5-3-1/h1-4h,5-8h2/b3-1-,4-2
1,3-cyclooctadiene, (1z,3z)-
cis,cis-1,3-cyclooctadiene, 98%
cyclooctadiene
1,3-cyclooctadiene, technical, >=95% (gc)
cycloocta-1,3-diene
(1z,3e)-cycloocta-1,3-diene
cyclooctadienes
cyclooctadienes [un2520] [flammable liquid]
un2520
29965-97-7
3806-59-5
AKOS025295254
RRKODOZNUZCUBN-CCAGOZQPSA-N
RRKODOZNUZCUBN-PBIXIIOPSA-N
mfcd00001751
J-010594
1.3-cyclooctadiene
DTXSID30865523
Q56683052
EN300-6489763
AS-75607
EN300-179757
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.51 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.78 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.51)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]